周旭宇 - 中国科学院微生物研究所 -

个人简介

1989-1993 年山东大学学士 1993-1996 年山东农业大学硕士（师从温孚江教授） 1997-2001 年大阪大学博士（师从Toshiyuki Hamaoka教授） 2001-2003 年大阪大学交流学者/研究助理 2003-2009 年美国加州大学旧金山分校（UCSF），博士后（师从Jeffery A. Bluestone教授） 2009-至今中国科学院微生物研究所研究员、博士生导师

研究领域

调节性T细胞（Treg）的抑制机理及其免疫调控机制研究，探索选择性干预Treg细胞和其他效应性T细胞，进行肿瘤、感染性和自身免疫性疾病的治疗

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhang Z, Zhou X. Foxp3 Instability Helps tTregs Distinguish Self and Non-self. Front Immunol. 2019 Sep 24; 10: 2226. doi: 10.3389/fimmu.2019.02226. eCollection 2019. 2. Xueping Zhu, Wei Zhang, Jie Guo, Xuejie Zhang, Liping Li, Ting Wang, Jinghua Yan, Fuping Zhang, Baidong Hou, Ning Gao, George F Gao*, Xuyu Zhou*. Noc4L mediated ribosome biogenesis controls activation of regulatory T cell and conventional T cell. Cell Reports. 2019, 27(4): 1205-1220 3. Krung Phiwpan, Xuyu Zhou*. MicroRNAs in regulatory T cells. Cancer Letters, 2018, 423, 80-85. 4. Xundong Wei, Jianhua Zhang, Qianchong Gu, Man Huang, Wei Zhang, Jie Guo, Xuyu Zhou*. Reciprocal Expression of IL-35 and IL-10 Defines Two Distinct Effector Treg Subsets that Are Required for Maintenance of Immune Tolerance. Cell Reports. 2017, 21(7), 1853-1869. 5. Zhongmei Zhang, Wei Zhang, Jie Guo, Qianchong Gu, Xueping Zhu, Xuyu Zhou*. Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability. Journal of Immunology. 2017, 198(7): 2612-2625. 6. Decong Kong, Zhe Chen, Junping Wang, Qingyu Lv, Hua Jiang, Yuling Zheng, Maokai Xu, Xuyu Zhou*,Huaijie Hao*, Yongqiang Jiang*. Interaction of factor H-binding protein of Streptococcus suis with globotriaosylceramide promotes the development of meningitis. Virulence. 2017, 8(7): 1290-1302. 7. Man Huang, Wei Zhang, Jie Guo, Xundong Wei, Krung Phiwpan, Jianhua Zhang*, Xuyu Zhou*. Improved Transgenic Mouse Model for Studying HLA Class I Antigen Presentation. Scientific Reports. 2016, doi:10.1038/srep33612. 8. Tanyu Hu, Krung Phiwpan, Jitao Guo, Wei Zhang, Jie Guo, Zhongmei Zhang, Mangge Zou, Xuejie Zhang, Jianhua Zhang, Xuyu Zhou*. MicroRNA-142-3p Negatively Regulates Canonical Wnt Signaling Pathway. PLoS One, 2016, DOI:10.1371/journal.pone.0158432 9. Jitao Guo and Xuyu Zhou*. Regulatory T cells turn pathogenic. Cellular & Molecular Immunology (2015), 1–8. 10. Krung Phiwpan, Jie Guo, Wei Zhang, Tanyu Hu, Bhargavi M Boruah, Jianhua Zhang, Xuyu Zhou*. A novel transgenic mouse line for tracing microRNA-155-5p activity in vivo. PLoS One. 2015, 10(6):e0128198. 11. Jitao Guo, Jianhua Zhang, Xuejie Zhang, Zhongmei Zhang, Xundong Wei and Xuyu Zhou*. Constitutive activation of MEK1 promotes Treg cell instability in vivo. Journal of Biological Chemistry. 2014, 289(51):35139-48. 12. Peipei Liu, Di Liu, Xi Yang, Jing Gao, Yan Chen, Xue Xiao, Fei Liu1, Jing Zou, Jun Wu, Juncai Ma, Fangqing Zhao, Xuyu Zhou*, George F. Gao*, Baoli Zhu*. Characterization of human αβTCR repertoire and discovery of D-D fusion in TCR β chains. Protein & Cell. 2014, 5(8):603-15. 13. Lv Q, Hao H, Bi L, Zheng Y, Zhou X*, Jiang Y*. Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activation RhoA and Rac1 GTPase. Protein & Cell. 2014, 5(4):261-4 14. Hao H, Hui W, Liu P, Lv Q, Zeng X, Jiang H, Wang Y, Zheng X, Zheng Y, Li J*, Zhou X*, Jiang Y*. Effect of licochalcone A on growth and properties of Streptococcus suis. PLoS One. 2013, 8(7):e67728. 15. Zhou X, Bailey-Bucktrout S, Jeker LT, Bluestone JA*. Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol. 2009 Jun, 21(3):281-5. Review. 16. Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA*. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol. 2009 Sep, 10(9):1000-7. 17. Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA*. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med. 2008 Sep 1, 205(9):1983-91. 18. Zhou, XY, Yashiro-Ohtani, Y, Toyo-oka, K, Park, CS, Tai, XG, Hamaoka, T, Fujiwara, H*. CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4(+)CD8(+) thymocytes and supports their differentiation to the CD4 lineage. The Journal of Immunology, 164(3): 1260-1268. 19. Zhou, XY, Yashiro-Ohtani, Y, Nakahira, M, Park, WR\, Abe, R, Hamaoka, T, Naramura, M, Gu, H, Fujiwara, H*. Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation. The Journal of Immunology, 168(8): 3847-3854. 20. 张雪洁，张建华，张伟，郭洁，周旭宇*，小鼠T-bet逆转录病毒载体的构建与功能验证，生物工程学报，2014，30（10），1586-1593