叶昕 - 中国科学院微生物研究所 -

个人简介

1980-1984 厦门大学学士 1984-1987 中科院上海细胞生物学研究所硕士 1987-1990 中国医学科学院肿瘤研究所博士 1990-1992 中科院上海生物化学研究所 1992-1993 中科院上海生物工程中心副教授 1994-1995 美国洛克菲勒大学博士后 1995-1998 美国哥伦比亚大学博士后 1998-2000 美国伊利诺伊斯大学芝加哥分校资深研究员 2000-2003 美国贝勒医学院讲师 2003-2005 美国哈佛医学院讲师 2005-至今中科院微生物所研究员、博士生导师

研究领域

1、流感病毒复制的分子机制及抗病毒天然免疫的调控机理 2、乙型肝炎病毒调控细胞周期/细胞凋亡及肝癌发生发展的机理

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Qi Liu, Ningning Liu, Qilin Shangguan, Fang Zhang, Wenjia Chai, Xiaomei Tong, Xin Zhao, Zhiwei Li, Dandan Qi, and Xin Ye, LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1. Sci Rep. 2019; 9: 11593. 2.Xinda Li, Guijie Guo, Min Lu, Wenjia Chai, Yucen Li, Xiaomei Tong, Jing Li, Xiaojuan Jia, Wenjun Liu, Dandan Qi, Xin Ye. Lnc-MxA inhibits IFN-β transcription via forming RNA-DNA triplexes at its promoter. J Virol. 2019, DOI: 10.1128/JVI.00786-19. 3.Dandan Qi, Lei Hu, Tong Jiao, Tinghong Zhang, Xiaomei Tong, Xin Ye. Phosphatase Cdc25A negatively regulates antiviral immune response by inhibiting TBK1 activity. J Virol. 92(19):e01118-18, 2018. 4.Wenjia Chai, Jing Li, Qilin Shangguan, Qi Liu, Xinda Li, Dandan Qi, Xiaomei Tong, Wenjun Liu, Xin Ye. Lnc-ISG20 inhibits influenza A virus replication by enhancing ISG20 expression. J Virol. 92(16):e00539-18, 2018. 5.Ningning Liu, Qi Liu, Xiaohai Yang, Fang Zhang, Xinda Li, Yuanwu Ma, Feifei Guan, Xin Zhao, Zhiwei Li, Lianfeng Zhang, Xin Ye. Hepatitis B virus-upregulated lnc-HUR1 promotes cell proliferation and tumorigenesis by blocking p53 activity. Hepatology. 2018, 68(6):2130-2144., 2018. 6.Ningning Liu, Jinfang Zhang , Xiaohai Yang, Tong Jiao, Xin Zhao,Wenxia Li, Jianhua Zhu, Pu Yang, Jianping Jin, Jirun Peng, Zhiwei Li, Xin Ye. HDM2 promotes the NEDDylation of HBV HBx and enhances its stability and functions. J Virol.91, e00340-17, 2017. 7.Tinghong Zhang, Zhen Ye, Xiaohai Yang, Yujie Qin,Yi Hu, Xiaomei Tong, Wenbin Lai, Xin Ye. NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus. Sci Rep. 7: 43691, 2017. 8.Yi Hu, Liangzhen Jiang, Wenbin Lai, Yujie Qing, Tinghong Zhang, Shixiong Wang, Xin Ye. MiR-33a disturbs influenza A virus replication via targeting ARCN1 and inhibiting viral vRNP activity. J Gen Virol. 97(1):27-38, 2016. 9.Yan Huang, Liping Sun, Ningning Liu, Qian Wei, Liangzhen Jiang，Xiaomei Tong , Xin Ye. Plk1 up-regulates telomerase activity by affecting hTERT stability telomerase activity by affecting hTERT stability. J Biol Chem. 290:18865-73, 2015. 10.Liping Sun, Yan Huang, Qian Wei, Xiaomei Tong, Rong Cai, Grzegorz Nalepa, Xin Ye. Cyclin E-CDK2 Protein Phosphorylates Plant Homeodomain Finger Protein 8 (PHF8) and Regulates Its Function in the Cell Cycle. J Biol Chem. 290, 4075-4085, 2015. 11.Ningning Liu, Tong Jiao, Yan Huang, Wenjun Liu, Zhiwei Li, Xin Ye. Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7- Transforming Growth Factor Beta Pathway. J Virol 89, 2739-2749, 2015. 12.Yetao Wang, Lei Hu, Xiaomei Tong and Xin Ye. Casein Kinase 1γ1 Inhibits the RIG-I/TLR Signaling Pathway through Phosphorylating p65 and Promoting Its Degradation. J Immunol. 192:1855-61, 2014. 13.Ningning Liu, Jinfang Zhang, Tong Jiao, Zhiwei Li, Jirun Peng, Qingqing, Cuizhu, Xin Ye. Hepatitis B virus inhibits apoptosis of hepatoma cells by sponging miR-15a/16 cluster. J Virol. 87(24):13370-78, 2013. 14. Zhaoyang Du, Xiaomei Tong, Xin Ye. Cyclin D1 Promotes Cell Cycle Progression through Enhancing NDR1/2 Kinase Activity Independent of Cyclin-dependent Kinase 4. J Biol. Chem. 288(37):26678-87. 15. Qian Wei, Junhui Li, Ting Liu, Xiaomei Tong, Xin Ye. Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation. J Biol Chem 288: 19715–19725, 2013. 16. Liangzhen Jiang, Yan Huang, Min Deng, Ting Liu, Wenbin Lai, Xin Ye. Polo-Like Kinase 1 Inhibits the Activity of Positive Transcription Elongation Factor of RNA Pol II b (P-TEFb). PLoS ONE 8(8):e72289, 2013. 17. Yetao Wang, Xiaomei Tong, Gang Li, Junhui Li, Min Deng, Xin Ye. Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling. Euro. J Immunol. 42: 1304–1315, 2012. 18. Yetao Wang, Xiaomei Tong, Junjie Zhang, Xin Ye. The complement C1qA enhances RIG-I mediated immune signaling. Immunol. 136:78-85, 2012. 19. Yetao Wang, Xiaomei Tong and Xin Ye. Ndfip1 Negatively Regulates RIG-I- Dependent Immune Signaling by Enhancing E3 Ligase Smurf1-Mediated MAVS Degradation. J Immunol. 189:5304-5313, 2012. 20. Yetao Wang, Xiaomei Tong, Ehimwenma Sheena Omoregie, Wenjun Liu, Songdong Meng, and Xin Ye. Tetraspanin 6 (TSPAN6) Negatively Regulates Retinoic Acid- inducible Gene I-like Receptor-mediated Immune Signaling in a Ubiquitination- dependent Manner. J Biol Chem. 287: 34626–34634, 2012.