田勇 - 中国科学院生物物理研究所 -

个人简介

中国科学院生物物理研究所研究员，博士生导师。2012年起担任中国科学院生物物理研究所动物实验中心主任；中国科学院核酸生物学重点实验室课题组组长。2015年起担任中国科学院大学岗位教授。2016年起担任中国科学院动物实验平台工作委员会主任。2017年起担任中国实验动物学会第七届理事会常务理事，《Animal Models and Experimental Medicine》杂志副主编

研究领域

1、基因编辑技术（CRISPR/Cas9）的研发与改良 2、基因编辑技术（CRISPR/Cas9）在模式生物疾病动物模型研发中的应用 3、利用动物模型开展非编码核酸（lncRNA）和环形RNA (circRNA) 在体功能的研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Song G, Zhang F, Zhang X, Gao X, Zhu X, Fan D, Tian Y*. AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target Cleavage. Cell Rep. 2019 Nov 26;29(9):2579-2589.e4. doi: 10.1016/j.celrep.2019.10.078. 2. Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y*, Fan Z*. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020 Feb 3;217(2). pii: e20190974. doi: 10.1084/jem.20190974. 3. Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y*, Fan Z*. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 2019 Nov 4;216(11):2653-2668. doi: 10.1084/jem.20182363. 4. Zhang F, Song G, Tian Y*. Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems. Animal Model Exp Med. 2019 May 29;2(2):69-75. doi: 10.1002/ame2.12069. 5. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y*, Fan Z*. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 Sep 2;38(17):e101110. doi: 10.15252/embj.2018101110. 6. Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019 Feb;20(2):183-194. doi: 10.1038/s41590-018-0297-6. 7. Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018 Sep 17. doi: 10.1038/s41556-018-0194-0. 8. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S,Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y*, Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 2018 Oct;69(4):861-872. doi: 10.1016/j.jhep.2018.03.029. 9. Gao L, Wu K, Liu Z, Yao X, Yuan S, Tao W, Yi L, Yu G, Hou Z, Fan D, Tian Y, Liu J, Chen ZJ, Liu J. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell. 2018 Mar 22;173(1):248-259.e15. doi: 10.1016/j.cell.2018.02.028. 10. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S,Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y*, Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 2018 Apr 10. pii: S0168-8278(18)31971-8. doi: 10.1016/j.jhep.2018.03.029. 11. Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y*, Fan Z*. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261. doi: 10.1038/s41467-018-03008-2. 12. Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R*, Tian Y*, Fan Z*. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018 Mar 13. pii: e97174. doi: 10.15252/embj.201797174. 13. Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y*, Fan Z*.The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018 Jan 1. doi: 10.1038/s41590-017-0014-x. 14. Liu B, Ye B, Zhu X, Huang G, Zhu P, Yang L, Du Y, Wu J, Meng S, Tian Y*, Fan Z*. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 2017 Aug 10. doi:10.1038/s41467-017-00235-x. 15. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017 Mar 20. doi: 10.1038/ni.3712. 16. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Feb 1. doi: 10.1038/ni.3356. 17. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015 Apr 2;16(4):413-25. doi: 10.1016/j.stem.2015.03.003. 18. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y*, Fan Z*. The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J Immunol. 2015 Feb 1;194(3):1292-303. doi: 10.4049/jimmunol.1402593. 19. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014 Nov 17;211(12):2439-54. doi: 10.1084/jem.20141123. 20. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S*, Tian Y*. An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420. 21. Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell. 2014 Apr 14;25(4):455-68. doi: 10.1016/j.ccr.2014.02.007. 22. Han J, Li J, Jia W, Yao L, Li X, Jiang L*, Tian Y*. Photothermal therapy of cancer cells using novel hollow gold nanoflowers. Int J Nanomedicine. 2014 Jan 16;9:517-26. doi: 10.2147/IJN.S55800.