个人简介
滕兆乾,博士,研究员,博士生导师,干细胞与脑损伤修复研究组组长。
2005年博士毕业于中国科学院动物研究所,先后在中国农业大学、美国新墨西哥大学医学院、路易斯安那州立大学健康科学中心以及约翰霍普金斯大学医学院做博士后与ResearchAssociate,2015年获得中国科学院“百人计划”资助。主要从事神经发生、脑损伤与神经退行性疾病方面的研究,研究成果发表在Cell、CellStemCell、StemCellReports、TheNeuroscientist、StemCells、JournalofNeuroscience、FrontiersinMolecularNeuroscience、JournalofCerebralBloodFlowandMetabolism等国际学术期刊上。承担科研项目情况:
1.2015-2017中国科学院“百人计划”,主持,在研
2.2016-2019国家自然科学基金面上项目,主持,在研
研究领域
研究领域:
研究工作主要集中在创伤性脑病的发病机理、神经发生与胶质发生的分子调控、以及干细胞在脑损伤修复中的应用研究。研究组的主要研究方向包括:(1)脑损伤后,大脑内环境变化对神经发生、胶质发生与神经再生影响的分子机理;(2)慢性创伤性脑病的分子致病机制;(3)功能性小胶质细胞与星形胶质细胞的定向分化;(4)探索通过干细胞移植和改善神经再生与可塑性内环境而实现脑损伤修复的有效途径。
承担科研项目情况:
1.2015-2017中国科学院“百人计划”,主持,在研
2.2016-2019国家自然科学基金面上项目,主持,在研
近期论文
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Pei-PeiLiu,Gang-BinTang,Ya-JieXu,Yu-QiangZeng,Shuang-FengZhang,Hong-ZhenDu,Zhao-QianTeng*,Chang-MeiLiu*.MiR-203InterplayswithPolycombRepressiveComplexestoRegulatetheProliferationofNeuralStem/ProgenitorCells.StemCellReports.2017,9(1):190-202.(*Co-correspondenceauthor)
Gang-BinTang,Yu-QiangZeng,Pei-PeiLiu,Ting-WeiMi,Shuang-FengZhang,Shang-KunDai,Qing-YuanTang,YangLin,Ya-JieXu,Hai-LiangYan,Hong-ZhenDu,Zhao-QianTeng*,Feng-QuanZhou*,Chang-MeiLiu**.TheHistoneH3K27DemethylaseUTXRegulatesSynapticPlasticityandCognitiveBehaviorsinMice.Front.Mol.Neurosci.2017,10:267.doi:10.3389/fnmol.2017.00267(*Co-correspondenceauthor)
Pei-PeiLiu,Ya-JieXu,Zhao-QianTeng*,Chang-MeiLiu*.PolycombRepressiveComplex2:EmergingRolesintheCentralNervousSystem.TheNeuroscientist2017,doi:10.1177/1073858417747839.(Inpress)
PingLi,Zhao-QianTeng,Chang-MeiLiu*.ExtrinsicandIntrinsicRegulationofAxonRegenerationbyMicroRNAsafterSpinalCordInjury.NeuralPlasticity.2016:1279051.
JianZhang,Zhao-QianTeng,YunpingSong,MeiHu,ChuChen.Inhibitionofmonoacylglycerollipasepreventschronictraumaticencephalopathy-likeneuropathologyinamousemodelofrepetitivemildclosedheadinjury.JCerebBloodFlowMetab.2015Mar;35(3):443-453.
JianZhang,MeiHu,Zhao-QianTeng,YunpingSong,ChuChen.SynapticandCognitiveImprovementsbyInhibitionof2-AGMetabolismArethroughUpregulationofMicroRNA-188-3pinaMouseModelofAlzheimer'sDisease.JNeurosci.2014Nov5;34(45):14919-14933.
RongqingChen*,JianZhang*,NiFan*,Zhao-QianTeng*,YanWu*,HongweiYang,YaPingTang,HaoSun,YunpingSong,ChuChen.Δ9-THC-CausedSynapticandMemoryImpairmentsAreMediatedthroughCOX-2Signaling.Cell,2013,155(5),1154-1165.(*Co-firstauthor)
ChangmeiLiu,Zhao-QianTeng,AndreaLMcQuate,EmilyMJobe,ChristaCChrist,SergeiJvonHoyningen-Huene,MarieDReyes,EricDPolich,YinaXing,YueLi,WeixiangGuo,XinyuZhao.AnEpigeneticFeedbackRegulatoryLoopInvolvingMicroRNA195andMBD1GovernsNeuralStemCellDifferentiation.PLoSONE,2013,8(1):e51436.doi:10.1371/journal.pone.0051436.
RongqingChen,JianZhang,YanWu,DongqingWang,GuopingFeng,Ya-PingTang,Zhao-QianTeng,ChuChen.MonoacylglycerolLipaseIsaTherapeuticTargetforAlzheimer'sDisease.CellReports,2012,2(5):1329-1339.
ManavendraPathania,JuanTorres-Reveron,LilyYan,TomokiKimura,TiffanyVLin,ValerieGordon,Zhao-QianTeng,XinyuZhao,TudorAFulga,DavidVanVactor,AngéliqueBordey.miR-132enhancesdendriticmorphogenesis,spinedensity,synapticintegration,andsurvivalofnewbornolfactorybulbneurons.PLoSONE,2012,7(5):e38174.doi:10.1371/journal.pone.0038174.
WeixiangGuo,LiZhang,DevinM.Christopher,Zhao-QianTeng,SarahR.Fausett,ChangmeiLiu,OliviaL.George,JohnKlingensmith,PengJin,XinyuZhao.RNAbindingproteinFXR2regulatesproliferationanddifferentiationofadulthippocampalneuralstemcellsbyrepressingNogginexpression.Neuron,2011,70:924-938.
ChangmeiLiu*,Zhao-QianTeng*,NicholasJ.Santistevan,KeithE.Szulwach,WeixiangGuo,PengJin,XinyuZhao.EpigeneticRegulationofmiR-184byMBD1GovernsNeuralStemCellProliferationandDifferentiation.CellStemCell,2010,6:433-444.(*Co-firstauthor)
RichardD.Smrt,KeithE.Szulwach,RebeccaL.Pfeiffer,XuekunLi,WeixiangGuo,ManavendraPathania,Zhao-QianTeng,YupingLuo,JunminPeng,AngeliqueBordey,PengJin,XinyuZhao.MicroRNAmiR-137RegulatesNeuronalMaturationbyTargetingUbiquitinLigaseMindBomb-1.StemCells,2010,28:1060-1070.