个人简介

学习经历： 1999年-2005年北京大学生命科学院理学博士 工作经历： 2005年7月-2008年7月PostdoctoralFellow,DepartmentofMedicine,SectionofHematology/Oncology,UniversityofChicago,USA 2008年7月-2009年8月PostdoctoralScholar/ResearchAssociate,PharmacogeneticsAnticancerAgentsResearchGroup,UniversityofChicago,USA 2009年8月-至今中国科学院北京基因组研究所研究员博士生导师

研究领域

肿瘤基因组学、药物遗传学

承担科研项目情况： 1.国家自然科学基金重大国际合作研究项目：利用开放科学数据云促进高通量肿瘤基因组研究(31161120358),2012-2016，在研，主持； 2.科技部973项目：DNA损伤响应重要蛋白维持基因组稳定性机制研究（2015CB910603）,2015-2019,在研，课题骨干 3.科技部973项目：在肺癌微环境中表观遗传修饰对肺癌发展转移的作用机制（2011CB510106）,2011-2015，在研，课题骨干； 4.国家自然科学基金面上项目：白血病异常融合蛋白MLL-ENL对小鼠细胞全基因组microRNA的表达调控研,2011-2013，结题，主持； 5.教育部留学回国人员启动基金，主持。 发表专利： 1.天花粉蛋白突变体及其编码基因。200410074324.6 2.MutantsofTrichosanthinWithAnti-TumorActivityandLoweredSide-Effects.US2008261874/WO2006026906,USA

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.ZhangJ,LiS,LiL,LiM,GuoC,YaoJ,MiSL*.ExosomalMicroRNA:Trafficking,sortingandfunction.GenomicsProteomicsBioinformatics.2015,13(1):17-24. 2.MiS,ZhangJ,ZhangW,HuangRS.CirculatingmicroRNAsasbiomarkersforinflammatorydiseases.MicroRNA.2013,2(1):64-72. 3.WangQF,WuG,MiS,HeF,WuJ,etal.MLLFusionProteinsPreferentiallyRegulateaSubsetofWildTypeMLLTargetGenesintheLeukemicGenome.Blood.2011,117:6895-6905 4.WenY,GamazonER,BleibelWK,WingC,MiS,etal.AneQTL-basedmethodidentifiesCTTNandZMAT3aspemetrexedsusceptibilitymarkers.HumMolGenet.2011,21:1470-1480 5.TaoY,RuanJ,YehSH,LuX,WangY,etal.Rapidgrowthofahepatocellularcarcinomaandthedrivingmutationsrevealedbycell-populationgeneticanalysisofwhole-genomedata.PNatlAcadSciUSA.2011,108:12042-12047 6.MiS,LiZ,ChenP,HeC,CaoD,etal.AberrantoverexpressionandfunctionofthemiR-17-92clusterinMLL-rearrangedacuteleukemia.PNatlAcadSciUSA.2010,107:3710-3715 7.HuangRS,JohnattySE,GamazonER,ImHK,ZiliakD,etal.Platinumsensitivity-relatedgermlinepolymorphismdiscoveredviaacell-basedapproachandanalysisofitsassociationwithoutcomeinovariancancerpatients.ClinCancerRes.2011,17:5490-500. 8.StarkAL,ZhangW,MiS,DuanS,O'DonnellPH,etal.Heritableandnon-geneticfactorsasvariablesofpharmacologicphenotypesinlymphoblastoidcelllines.PharmacogenomicsJ.2010,10:505-512 9.HuangRS,MiS.Candidategenespharmacogeneticsofanti-canceragents.Pharmacogenomics,2009,10(5):719-720 10.HartfordC,DuanS,DelaneyS,MiS,KistnerE,etal.PopulationSpecificGeneticVariantsImportantinSusceptibilitytoCytarabineArabinosideCytotoxicity.Blood.2009,113:2145-2153 11.DuanS,HuangRS,ZhangW,MiS,BleibelWK,etal.ExpressionandAlternativeSplicingofFolatePathwayGenesinHapMapLymphoblastoidCellLines.Pharmacogenomics,2009.10:549-563 12.DuanS*,MiS*,ZhangW,DolanM.E.ComprehensiveanalysisoftheimpactofSNPsandCNVsonhumanmicroRNAsandtheirregulatorygenes.RNAbiology.2009,6:412-425.(*contributeequally) 13.LiZ,LuoRT,MiS,SunM,ChenP,etal.ConsistentderegulationofgeneexpressionbetweenhumanandmurineMLL-rearrangementleukemias.CancerRes.2009,69:1109-1116 14.LiZ*,LuJ*,SunM*,MiS*,ZhangH,etal.DistinctmicroRNAexpressionprofilesinacutemyeloidleukemiawithcommontranslocations.PNatlAcadSciUSA.2008,105:15535-15540(*contributeequally) 15.MiS,LuJ,SunM,LiZ,ZhangH,etal.MicroRNAexpressionsignaturesaccuratelydiscriminateacutelymphoblasticleukemiafromacutemyeloidleukemia.PNatlAcadSciUSA.2007,104:19971-19976 16.WangM,XieH,MiS,ChenJ.RecentpatentsontheidentificationandclinicalapplicationofmicroRNAsandtargetgenes.RecentPatentsonDNA&GeneSequences.2007,1:116-124 17.ZhangXY,WuY,YanJY,GaoY,WangY,etal.Y55andD78arecrucialaminoacidresiduesofanewIgEepitopeontrichosanthin.BiochemBiophyResCo.2006,343:1251-1256 18.MiSL,AnCC,WangY,ChenJY,CheNY,etal.Trichomislin,anovelribosome-inactivatingprotein,inducesapoptosisthatinvolvesmitochondriaandcaspase-3.ArchivesofBiochemistryandBiophysics.2005,434:258-265 19.WangY,MiSL,LouM,GaoY,ChenZL,etal.EnhancedGreenFluorescenceproteintracksTrichosanthininhumanchoriocarcinomacellsasafeasibleandstablereporter.FrontiersinBioscience.2005,10:2279-2284 20.YanY,AnC,LiL,GuJ,WangL,etal.Thesenseandantisenseexpressionofgibberellin20-oxidasegene(rga5)inriceanditseffectsonGA1levelandagronomictraits.ChineseScienceBulletin.2003,48:443-448