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个人简介

刘宏伟, 研究员/教授,博士生导师,享受国务院政府特殊津贴专家,入选国家级百千万人才工程,获“中青年有突出贡献专家”称号。担任中国科学院大学岗位教授,微生物与生化药学学科带头人。入选2021年度全球十万顶尖科学家。先后获得中国科学院优秀导师奖,中国科学院朱李月华优秀教师奖,西藏自治区科学技术一等奖、二等奖。指导研究生获得“中国科学院百篇优博论文”奖。 工作经历 2015-至今中国科学院大学 医学院 岗位教授 微生物与生化药学学科带头人 2011.8-现在 中国科学院微生物研究所真菌学国家重点实验室,研究员,课题组组长 2009.1-2011.8 中国科学院微生物研究所真菌地衣系统学重点实验室,副研究员,青年课题组组长 2006.10-2008.12 首都医科大学药学院,副教授 2004.10-2006.9清华大学生物系,博士后,助理研究员 教育背景 2001.10-2004.9日本东京海洋大学,水产学,博士学位 1998.9-2003.7沈阳药科大学,药物化学,博士学位 1993.9-1998.7沈阳药科大学药学系,英语药学专业,理学学士学位

研究领域

1)微生物药物先导化合物的挖掘、功能评价与作用机制研究 2) 微生物药物先导化合物的生物合成与合成生物学研究 3) 肠道菌群调节机制与新型益生菌研究

近期论文

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Qiao SS, Liu C, Sun L, Wang T, Dai HQ, Wang K, Bao L, Li HT, Wang WZ, Liu SJ*, Liu HW*(2022)Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism. Nat. Metab. doi: 10.1038/s42255-022-00649-y Wang T, Han JJ, Dai HQ, Sun JZ, Ren JW, Wang WZ, Qiao SS, Liu C, Sun L, Liu SJ, Li DP, Wei SL, Liu HW* (2022) Polysaccharides from Lyophyllum decastes reduce obesity by altering gut microbiota and increasing energy expenditure. Carbohydr Polym 295:119862. doi:10.1016/j.carbpol.2022.119862 Guo C, Dai HQ, Zhang M, Liao H, Zhang R, Chen BS, Han JJ, Liu HW* (2022) Molecular networking assisted discovery and combinatorial biosynthesis of new antimicrobial pleuromutilins. Eur J Med Chem 243:114713. doi:10.1016/j.ejmech.2022.114713 Zhang R, Wang HF, Chen BS, Dai HQ, Sun JZ, Han JJ, Liu HW* (2022) Discovery of Anti-MRSA Secondary Metabolites from a Marine-Derived Fungus Aspergillus fumigatus. Mar Drugs 20 (5). doi:10.3390/md20050302 Han JJ, Wang HY, Zhang R, Dai HQ, Chen BS, Wang T, Sun JZ, Wang WZ, Song FH, Li ER, Lyu ZT, Liu HW* (2022) Cyclic Tetrapeptides with Synergistic Antifungal Activity from the Fungus Aspergillus westerdijkiae Using LC-MS/MS-Based Molecular Networking. Antibiotics-Basel 11 (2). doi:ARTN 16610.3390/antibiotics11020166 Chen BS, Lin JH, Xu A, Yu D, Phurbu D, Dai HQ, Li Y, Liu HW* (2022) Glyceroglycolipids from the solid culture of Ophiocordyceps sinensis strain LY34 isolated from Tibet of China. Mycology 13 (3):185-194. doi:10.1080/21501203.2022.2036841 Ma K, Zhang YT, Guo C, Yang YL, Han JJ, Yu B, Yin WB, Liu HW* (2021) Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues. Acta Pharm Sin B 11 (9):2945-2956. doi:10.1016/j.apsb.2021.04.014 Qiao SS, Wang K, Liu C, Zhou N, Li B, Wang J, Liu SJ, Liu HW* (2021) The enriched gut commensal Faeciroseburia intestinalis contributes to the anti-metabolic disorders effects of the Ganoderma meroterpene derivative. Food Sci Hum Well 11 (1):85-96. doi:10.1016/j.fshw.2021.07.010 Sun L, Bao L, Phurbu D, Qiao SS, Sun SS, Perma Y, Liu HW* (2021) Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice. Food Sci Hum Well 10 (4):442-451. doi:10.1016/j.fshw.2021.04.006 Zhang JJ, Chen BS, Dai HQ, Ren JW, Zhou LW, Wu SH, Liu HW* (2021) Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang. Chin J Nat Medicines 19 (9):693-699. doi:10.1016/S1875-5364(21)60101-2 Hu XM, Li HY, Zhao XY, Zhou RL, Liu HH, Sun YS, Fan Y, Shi YA, Qiao SS, Liu SJ, Liu HW, Zhang SY* (2021) Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome. Theranostics 11 (12):5778-5793. doi:10.7150/thno.55946 Liu C, Du MX, Abuduaini R, Yu HY, Li DH, Wang YJ, Zhou N, Jiang MZ, Niu PX, Han SS, Chen HH, Shi WY, Wu L, Xin YH, Ma J, Zhou Y, Jiang CY, Liu HW, Liu SJ* (2021) Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank. Microbiome 9 (1):119. doi:10.1186/s40168-021-01064-3 Shanshan Qiao, Li Bao, Kai Wang, Shanshan Sun, Mingfang Liao, Chang Liu, Nan Zhou, Ke Ma, Yuwei Zhang, Yihua Chen, Shuang-Jiang Liu*, Hongwei Liu.* Activation of a specific gut Bacteroides-folate-liver axis benefits for the alleviation of nonalcoholic hepatic steatosis. Cell Reports, 2020, 32, DOI:https://doi.org/10.1016/j.celrep.2020.108005 (IF = 10.394) Chang Liu, Nan Zhou, Mengxuan Du, Yutong Sun, Kai Wang, Yujing Wang, Danhua Li, Haiying Yu, Yuqin Song, Bingbing Bai, Yuhua Xin, Linhuan Wu, Chengying Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, Hongwei Liu,* Shuangjiang Liu.* The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria. Nature Communications, 2020, doi.org/10.1038/s41467-019-13836-5. (IF=13.61) Shanshan Sun, Kai Wang, Li Sun, Baosong Cheng, Shanshan Qiao, Huanqin Dai, Wenyu Shi, Juncai Ma, Hongwei Liu*. Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis. Gut Microbes, 2020 DOI:10.1080/19490976.2020.1830693 (IF = 12.117) Baosong Chen#, Junjie Han#, Mengmeng Wang, Huanqin Dai, Jinjin Zhang, Lei Cai, Shenglong Wei, Xue Zhang and Hongwei Liu*. Amplisins A–E, chromone methide polymers with hypoglycemic activity from a new fungicolous fungus Amplistroma fungicola. Organic Chemistry Frontiers, 2020, 7, 2761-2769. Jinjin Zhang, Baosong Chen, Jack Liang, Junjie Han, Liwei Zhou, Ruilin Zhao, Hongwei Liu*, and Huanqin Dai*. Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from Mushroom Fomitopsis pinicola Collected in North America. Journal of Agricultural and Food Chemistry, 2020, 68(37),10036-10049 (IF=4.289). Kai Wang, Mingfang Liao, Nan Zhou, Li Bao, Ke Ma, Zhongyong Zheng, Yujing Wang, Chang Liu, Wenzhao Wang, Jun Wang, Shuangjiang Liu*, Hongwei Liu*. Parabacteroides distasonis alleviates obesity and metabolic dysfunctions via production of succinate and secondary bile acids. Cell Reports, 2019, 26, 222-235 (IF = 10.394; ESI 高被引论文). Ke Ma, Peng Zhang, Qiaoqiao Tao, Nancy P. Keller, Yanlong Yang, Wen-Bing Yin*, Hongwei Liu*. Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus. Organic Letters, 2019, 21 (9), 3252–3256. (IF=5.541) Sun Shan-Shan, Wang Kai, Ma Ke, Bao Li, Liu Hong-Wei*. An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota. Chin J Nat Med. 2019, 17(1): 3-14. Baosong Chen, Jinjin Zhang, Junjie Han, Ruilin Zhao, Li Bao*, Ying Huang, Hongwei Liu*. Lanostane triterpenoids with glucose-uptake-stimulatory activity from peels of the cultivated edible mushroom Wolfiporia cocos. Journal of Agricultural and Food Chemistry, 2019, 67, 7348-7364. (IF=4.289)

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