个人简介

学习经历： 1987年9月-1991年6月华中理工大学生物医学工程学士 1998年8月-2003年7月美国堪萨斯州立大学生物化学博士学位指导教授:PaulE.Smith 工作经历： 1991年7月-1998年7月军事医学科学院研究实习员/助理研究员指导教授:吴加金 2003年8月-2004年8月美国德拉华大学博士后指导教授:段勇 2004年9月-2008年2月美国加大戴维斯分校博士后、研究组主管指导教授:段勇 2008年3月-至今中科院北京基因组研究所“百人计划”研究员

研究领域

计算生物学,阿尔茨海默病

承担科研项目情况： 1.科技部973,2014CB964901,细胞命运维持与转化的表观遗传调控作用与机制研究,2014-2018年,在研,课题骨干。 2.自然科学基金,30870474,蛋白质-蛋白质对接的计算模型,2009-2011年,已结题,负责人。

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.JiajiaWang,XuemeiFengX,ZhouxianBai,Lee-wayJin,YongDuanY,andHongxingLei.(2013)Chromosome19pinAlzheimer’sdisease:whengenomemeetstranscriptome.JAlzheimer’sDiseaseonline. 2.GuangchunHan,JiajiaWang,FanZeng,XuemeiFengX,JunYu,HongyiCaoH,XuYi,HuadongZhou,Lee-wayJin,YongDuanY,YanjiangWangandHongxingLei.(2013)CharacteristictransformationofbloodtranscriptomeinAlzheimer’sdisease.JAlzheimer’sDisease35:373-386. 3.DapengLiang,GuangchunHan,XuemeiFeng,JiyaSun,YongDuanandHongxingLei.ConcertedperturbationobservedinahubnetworkinAlzheimer’sdisease.PLoSOne2012，7(7):e40498(correspondingauthor) 4.JiyaSun,XuemeiFeng,DapengLiang,YongDuanandHongxingLei.Down-regulationofenergymetabolisminAlzheimer’sdiseaseisaprotectiveresponseofneuronstothemicroenvironment.JAlzheimer’sDisease2012，28,389-402(correspondingauthor) 5.HongxingLei.AmyloidandAlzheimer’sdisease.Protein&Cell2010，1（4）,312-314 6.HongxingLei,YaoSu,LianJinandYongDuan.Thefoldingnetworkofvillinheadpiecesubdomain.BiophysJ2010，99：3374-3384(correspondingauthor) 7.HongxingLei,Zhi-XiangWang,ChunWuandYongDuan.Dualfoldingpathwaysofana/bproteinfromall-atomabinitiofoldingsimulations.J.Chem.Phys.2009，131,1651058.HongxingLei,ChunWu,Zhi-XiangWang,YaoqiZhou,andYongDuan.FoldingprocessesoftheBdomainofproteinAtothenativestateobservedinall-atomabinitiofoldingsimulations.JChemPhys2008,128(23):235105 9.HongxingLei,ChunWu,HaiguangLiuandYongDuan.FoldingfreeenergylandscapeofHP35frommoleculardynamicssimulations.PNAS,2007,104(12):4925-4930 10.HongxingLeiandYongDuan.Two-stagefoldingofHP-35fromAbinitiosimulation.J.Mol.Biol.,2007,370:196-206 11.HongxingLeiandYongDuan.Abinitiofoldingofalbuminbindingdomainfromall-atommoleculardynamicssimulation.JPhysChemB,2007,111:5458-5463. 12.HongxingLeiandYongDuan.Improvedsamplingmethodsformoleculardynamics.CurrOpinStructBiol,2007,17:187-191 13.HongxingLei;ShubhraGDastidarandYongDuan.FoldingTransitionStateandDenaturedStateEnsemblesofFSD-1fromFoldingandUnfoldingSimulations.JPhysChemB,2006,110:22001-22008 14.HongxingLei;ChunWu;Zhi-XiangWangandYongDuan.Moleculardynamicssimulationsandfreeenergyanalysesonthedimerformationofanamyloidgenicheptamerpeptidefromhumanβ2-microglobulin:implicationtotheprotofibrilstructure.J.Mol.Biol.,2006,356:1049-1063 15.ChunWu,HongxingLei,andYongDuan.Elongationoforderedpeptideaggregateofanamyloidgenichexapeptide(NFGAIL)observedinmoleculardynamicssimulationswithexplicitsolvent.JAmChemSoc,2005,127:13530-13537 16.HongxingLeiandYongDuan.Incorporatingintermoleculardistanceintoprotein-proteindocking.ProteinEngDesSel,2004,17(12):837-845 17.HongxingLeiandYongDuan.Theroleofplasticβ-hairpinandweakhydrophobiccoreinthestabilityandunfoldingofafullsequencedesignprotein.JChemPhys2004,121(23):12014-12111 18.HongxingLeiandPaulE.Smith.Theroleoftheunfoldedstateinhairpinstability.BiophysJ2003,85(6):3513-3520 19.HongxingLeiandPaulE.Smith.TheEffectsofInternalWaterMoleculesontheStructureandDynamicsofChymotrypsinInhibitor2.JPhysChemB.2003,107:1395-1402 20.LiWuJu,LeiHongXing,PeiWuHongandWuJiaJin.GeneDn:forhigh-levelexpressiondesignofheterologousgenesinaprokaryoticsystem.Bioinformatics,1998,14(10):884-885

学术兼职

AssociateEditor，JournalofAlzheimer’sDisease.AssociateEditor，Genomics,Proteomics&Bioinformatics.