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个人简介

1979-1983 年 山西农业大学 学士 1983-1986 年 北京农业大学 硕士 1986-1991 年 北京农业大学 助教 / 讲师 1991-1994 年 英国牛津大学 博士 ( DPhil-Oxon )(师从 David H L Bishop, Ernest A Gould ) 1994 年(3个月) 加拿大 Calgary University 博士后(师从 Robert Bell ) 1995-1998 年 英国牛津大学 博士后(师从 John I bell, Andrew J McMichael, Bent K Jakobsen ) 1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后(师从 Don C Wiley, Stephen C Harrison )(工作期间资助:英国 Wellcome Trust International Travelling Fellow ) 2001-2004 年 英国牛津大学 讲师、博士生导师、 Group leader 2004 -2008年 中国科学院微生物研究所 所长 2004-至今 中国科学院微生物研究所 研究员、博士生导师 2008-至今 中国科学院北京生命科学研究院 副院长,中国科学院病原微生物与免疫学重点实验室主任 2015年-至今 中国科学院大学医学院 院长 2011-2017 中国疾病预防控制中心副主任 2017-至今 中国疾病预防控制中心主任

研究领域

流感等囊膜病毒与宿主的相互作用,T细胞免疫与分子识别,新发、再发传染病,公共卫生政策与全球健康策略的研究

近期论文

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Wu, Y., Zhu, Y., Gao, F., Jiao, Y., Oladejo, B.O., Chai, Y., Bi, Y., Lu, S., Dong, M., Zhang, C., Huang, G., Wong, G., Li, N., Zhang, Y., Li, Y., Feng, W.H., Shi, Y., Liang, M., Zhang, R., Qi, J., Gao*, G.F., 2017, Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(36):E7564-E7573. Peng, R., Zhang, S., Cui, Y., Shi, Y., Gao*, G.F., Qi*, J., 2017, Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus, Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(42):E8905-E8912. Tan, S., Zhang, H., Chai, Y., Song, H., Tong, Z., Wang, Q., Qi, J., Wong, G., Zhu, X., Liu, J., Gao, S., Wang, Z., Shi, Y., Yang, F., Gao*, G. F. and Yan*, J., 2017, An unexpected N-terminal loop in PD-1 dominates the binding by nivolumab, Nature Communications, 8: 14369. doi: 10.1038/ncomms14369. Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Wu, Y., Yan, J., Shi*, Y., Zhang*, X. and Gao*, G. F., 2017, Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor-binding domains. Nature Communications, 8: 15092. Doi: 10.1038/ncomms15092. Li, A., Lu, G., Qi, J., Wu, L., Tian, K., Luo, T., Shi, Y., Yan*, J. and Gao*, G. F., 2017, Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein. PLoS Pathogens,13(5):e1006314. Duan, W., Song, H., Wang, H., Chai, Y., Su, C., Qi, J., Shi*, Y. and Gao*, G. F., 2017, The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO Journal, 36 (7): 919-933. Liu, K., Tan, S., Chai, Y., Chen, D., Song, H., Zhang, C. W.-H., Shi, Y., Liu, J., Tan, W., Lv, J., Gao, S., Yan, J., Qi*, J. and Gao*, G. F., 2017, Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy. Cell Research, 27 (1): 151-153. Peng, R., Xu, Y., Zhu, T., Li, N., Qi, J., Chai, Y., Wu, M., Zhang, X., Shi, Y., Wang, P., Wang*, J., Gao*, N. and Gao*, G. F., 2017, Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures. Cell Research, 27(7):853-864. Ma, W., Li, S., Ma, S., Jia, L., Zhang, F., Zhang, Y., Zhang, J., Wong, G., Zhang, S., Lu, X., Zhang, H., Yan, J., Li, W., Qin, C., Han, D., Qin, C., Wang, N., Li*, X. and Gao*, G. F., 2016, Zika virus causes testis damage and leads to male infertility in mice, Cell, 167 (6): 1511-1524. Bi, Y., Chen, Q., Wang, Q., Chen, J., Jin, T., Wong, G., Quan, C., Liu, J., Wu, J., Yin, R., Zhao, L., Li, M., Ding, Z., Zou, R., Xu, W., Li, H., Wang, H., Tian, K., Fu, G., Huang, Y., Shestopalov, A. M., Li, S., Xu, B., Yu, H., Luo, T., Lu, L., Xu, X., Luo, Y., Liu*, Y., Shi*, W., Liu*, D. and Gao*, G. F., 2016, Genesis, evolution and prevalence of H5N6 avian influenza viruses causing sporadic human infections. Cell Host and Microbe, 20 (6): 810-821. (Cover story) Wang, Q., Yang, H., Liu, X., Dai, L., Ma, T., Qi, J., Wong, G., Peng, R., Liu, S., Li, J., Li, S., Song, J., Liu, J., He, J., Yuan H., Xiong, Y., Liao, Y., Li, J., Yang, J., Tong, Z., Griffin, B. D., Bi, Y., Liang, M., Xu, X., Qin, C., Cheng, G., Zhang, X., Wang, P., Qiu, X., Kobinger, G., Shi, Y., Yan*, J. and Gao*, G. F., 2016, Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. Science Translational Medicine, 8 (369): 369ra179. (Cover story) Mosyoki A. M., Shi, Z., Xuan, C., Lu, G., Qi, J., Gao, F., Zheng, B., Zhang, Q., Li, Y., Haywood, J., Liu, C., Yan, J., Shi, Y. and Gao*, G. F., 2016, Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram positive bacterium Streptococcus suis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 113 (48): 13869-13874. Xu, X., Song, H., Qi, J., Liu, Y., Wang, H., Su, C., Shi*, Y. and Gao*, G. F., 2016, Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure. EMBO Journal, 35 (20): 2170-2178. (Cover story) Huang, C., Liu, J., Xu, W., Jin, T., Zhao, Y., Song, J., Shi, Y., Ji, W., Jia, H., Zhou, Y., Wen, H., Zhao, H., Liu, H., Li, H., Wang, Q., Wu, Y., Wang, L., Liu, D., Liu, G., Yu, H., Holmes, E. C., Lu*, L. and Gao*, G. F., 2016, A bat-derived putative cross-family recombinant coronavirus with a reovirus gene. PLoS Pathogens, 12 (9): e1005883. doi: 10.1371/journal.ppat.1005883. Wang, H., Shi, Y., Song, J., Qi, J., Lu, G., Yan, J., Gao*, G. F., 2016, Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1, Cell, 164(1-2):258-268 Song, H., Qi, J., Haywood, J., Shi*, Y. and Gao*, G. F., 2016, Zika virus NS1 structure reveals a diversified electrostatic surface for flavivirus. Nature Structural and Molecular Biology, 23(5):456-8. Haywood, J., Qi, J., Chen, C.-C., Lu, G., Liu, Y., Yan, J., Shi, Y., Gao*, G. F., 2016, Structural basis of collagen recognition by human osteoclast associated receptor: design of osteoclastogenesis inhibitors. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 113 (4): 1038-1043. Dai, L., Song, J., Lu, X., Deng, Y., Mosyoki, A. M., Cheng, H., Zhang, Y., Yuan, Y., Song, H., Haywood, J., Xiao, H., Yan, J., Shi, Y., Qin*, C., Qi*, J. and Gao*, G. F., 2016, Structures of the Zika virus envelope protein and its complex with a flavivirus broadly-protective antibody, Cell Host and Microbe, 19(5):696-704. Song, H., Qi, J., Khedri, Z., Diaz, S. L., Yu, H., Chen, X., Varki, A., Shi, Y. and Gao*, G. F., 2016, An open receptor-binding cavity of hemagglutinin-esterase-fusion glycoprotein from newly-identified influenza D virus: basis for its broad cell tropism. PLoS Pathogens, 12 (1): e1005411. Wu, Y., Cho, M.-S., Shore, D., Song, M., Choi, J.-A., Jiang, T., Deng, Y.-Q., Bourgeois, M., Almli, L., Yang, H., Chen, L.-M., Shi, Y., Qi, J., Li, A., Yi, K. S., Chang, M.-S., Bae, J. S., Lee, H.-J., Shin, J.-Y., Stevens, J., Hong, S.-S., Qin*, C.-F., Gao*, G. F., Chang*, S. J. and Donis*, R. O., 2015, A potent broad-spectrum protective human monoclonal antibody crosslinking two monomers of influenza A virus hemagglutinin. Nature Communications, 6: 7708. doi: 10.1038/ncomms8708.

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