研究领域
Using advanced nanoprobing systems providing new optical, electronic, and magnetic capabilities, we are aiming to visualize and to control dynamic motions of key biomolecules regulating important cellular processes such as development and tumorigenesis, and hence understand how the spatiotemporal dynamics of biomolecules across a cell population influence/determine the individual cells' fate and thus orchestrate ensemble behaviors of cells.
Our group is affiliated with the Department of Otolarynology, the UCSF Chemistry and Chemical Biology (CCB) Graduate Program, and the UCB-UCSF Bioengineering Graduate program.
近期论文
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Cheryl Tajon, Daeha Seo, Jennifer Asmussen, Neil Shah, Young-wook Jun* & Charles S. Craik*
"Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia"
ACS Nano, 8, 9199 (2014).
Daeha Seo, Justin Farlow, Kade Southard, Young-wook Jun* & Zev J. Gartner*
"Production & targeting of monovalent quantum dots"
The Journal of Visualized Experiments (JoVE), 92, e52198 (2014).
Cheryl Tajon, Young-wook Jun & Charles S. Craik*
"Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology"
Methods in Enzymology, 544, 271 (2014).
Jennifer Gajan, Elisabeth A. Lasaster, Cheryl Tajon, Juan Ose-Proetp, Young-wook Jun, Barry S.Taylor, Alma Burlingame, Charles S. Craik & Neil P. Shah*
"MEK-dependent negative feedback underlies BCR-ABL mediated oncogene addiction"
Cancer Discovery, 4, 200 (2014).
Justin Farlow, Daeha Seo, Kyle E. Broaders, Marcus Taylor, Zev J. Gartner* & Young-wook Jun*
"Formation of targeted monovalent quantum dots by steric exclusion"
Nature Methods, 10, 1203 (2013).
Before UCSF
Young-wook Jun, Hea-Won Chung, Jung-tak Jang & Jinwoo Cheon*
"Multiple twinning drives nanoscale hyper-branching of titanium dioxide nanocrystals"
Journal of Materials Chemistry 21, 10283 (2011).
Sassan Sheikholeslami‡, Young-wook Jun‡, Prashant Jain‡ & A. Paul Alivisatos*
"Coupling of optical resonances in an compositionally asymmetric plasmonic nanoparticle dimer"
Nano Letters 10, 2655 (2010).
Young-wook Jun, Sassan Sheikholeslami, Daniel Hostetter, Cheryl Tajon, Charles Craik & A. Paul Alivisatos*
"Continuous imaging of plasmon rulers in live cells reveals early stage caspase-3 activation at the single molecule level"
Proceedings of National Academy of Sciences USA, 106, 17735 (2009).
Haimei Zheng, Rachel K. Smith‡, Young-wook Jun‡, Christian Kisielowski, Ulrich Dahmen & A. Paul Alivisatos*
"Observation of single colloidal platinum nanocrystal growth trajectories"
Science 324, 1309 (2009).
Jungwon Park, Haimei Zheng, Young-wook Jun & A. Paul Alivisatos*
"Hetero-epitaxial anion exchange yields single-crystalline hollow nanoparticles"
Journal of the American Chemical Society, 131, 13943-13945 (2009).
Young-wook Jun, Jae-Hyun Lee, Mi-yun Kim & Jinwoo Cheon*
"Chemical design of nanoparticle probes for ultra-sensitive magnetic resonance imaging"
Angewandte Chemie International Edition, 47, 5122-5135 (2008).
Young-wook Jun, Jung-wook Seo & Jinwoo Cheon*
"Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences"
Accounts of Chemical Research, 41, 179-189 (2008).
Jae-Hyun Lee, Yong-Min Huh, Young-wook Jun, Jung-wook Seo, Jung-tak Jang, Ho-taek Song, Sungjun Kim, Jin-Suck Suh & Jinwoo Cheon*
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