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个人简介

赵镇文,中国科学院化学研究所活体分析化学院重点实验室。1996年8月-2000年6月,首都师范大学化学系毕业,获理学学士学位;2000年8月-2005年6月,中国科学院化学研究所毕业,获理学博士学位,专业分析化学;2005年8月-2006年3月,在美国克利夫兰临床医院勒那研究所(ClevelandClinicLernerResearchInstitute)博士后;2006年3月-2012年3月,美国印第安纳大学医学院(IndianaUniversitySchoolofMedicine)研究助理;2012年3月至今,中国科学院化学研究所研究员,致力于质谱分析方法以及脂质组学研究。迄今已在J.Clin.Oncol.,J.Lipid.Res.,Am.J.Pathol.,FASEBJ.,NatureMedicine,Angew.Chem.Int.Ed.等重要刊物上发表学术论文35篇,这些成果的科学意义得到了国际同行的肯定和认可。曾荣获2004年中国分析测试协会科学技术奖(CAIA奖)一等奖。

研究领域

研究方向 1、脂质分析在疾病诊断及治疗中的应用研究(脂质组学、色谱质谱学、分子生物学、蛋白质组学):主要包括鉴定生物活性脂质小分子及结构与功能,并鉴定脂质代谢的一些重要的蛋白酶及其功能,提供生物标志物或治疗靶标,力求对重大疾病尤其是癌症进行早期诊断或者预后参考。 脂质分析在疾病诊断及治疗中的应用研究 2、功能纳米结构界面及图像质谱应用研究(纳米材料制备、表面科学、质谱成像):主要包括基于功能化纳米结构界面及图像质谱,力求生命体系中异常活动的微弱或微纳尺度下化学信号的原位获取。

近期论文

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论文著作 1.YanboWei,ShumuLi,JingxiaWang,ChunyingShu,Jian’anLiu,ShaoxiangXiong,JianwenSong,JunjieZhang,ZhenwenZhao*,Polystyrenespheres-assistedMALDIMSforquantitativeanalysisofplasmalysophosphatidylcholines.AnalChem.2013,85:4729-4734. 2.HailanLiu,XiWu,ZizhengDong,ZhiyongLuo,ZhenwenZhao,YanXuandJian-TingZhang,FattyacidsynthasecausesdrugresistancebyinhibitingTNF-αandceramideproduction.JLipidRes.2013,inpress. 3.SongLi,BinGuo,JianwenSong,XiaoliDeng,YushengCong,PengfeiLi,KeZhao,LihongLiu,GangXiao,FengXu,YingjiangYe,ZhenwenZhao,MenggangYu,YanXu,JianliSang,JunjieZhang.Plasmacholine-containingphospholipids:potentialbiomarkersforcolorectalcancerprogression.Metabolomics.2013,9:202–212 4.NicholasJ.Skill,WuJianmin,XuYan,ZhenwengZhao,AlfredJ.Tector,MaryA.Maluccio,Lysophospholipidvariantsinhepatocellularcarcinoma.JSurgRes.2012inpress. 5.(*联合第一作者)QingchunCai*,ZhenwenZhao*,CarylAntalis*,LiboYan,AliHassanHamed,FrederickB.Stehman,JeanneM.Schilder,GiuseppeDelPriore,YanXu.ElevatedandsecretedPLA2activitiesasnewpotentialtherapeutictargetsinhumanepithelialovariancancer.FASEBJ,2012,26:3306-20. 6.IoannaNikitopoulou,NikosOikonomou,EmmanuelKarouzakis,IoannaSevastou,NefeliNikolaidou-Katsaridou,ZhenwenZhao,VassilisMersinias,MariaArmaka,YanXu,MasayukiMasu,GordonB.Mills,SteffenGay,GeorgeKollias,andVassilisAidinis.Autotaxinexpressionfromsynovialfibroblastsisessentialforthepathogenesisofmodeledarthritis.JExpMed.2012;209:925-33. 7.SuthatLiangpunsakul,YasmeenRahmini,RuthA.Ross,ZhenwenZhao,YanXu,andDavidW.Crabb.Imipramineblocksethanol-inducedASMaseactivation,ceramidegeneration,andPP2Aactivation,andameliorateshepaticsteatosisinethanol-fedmice.AmJPhysiolGastrointestLiverPhysiol.2012;302:G515-23. 8.ManuelaFunke,ZhenwenZhao,YanXu,JeroldChun,andAndrewM.Tager.TheLysophosphatidicAcidReceptorLPA1PromotesEpithelialCellApoptosisafterLungInjury.AmJRespirCellMolBiol.2012;46:355-64. 9.(*联合第一作者)HuiLi*,ZhenwenZhao*,CarylAntalis*,ZhanzhongZhao,RobertEmerson,GangWei,ShengZhang,Zhong-YinZhang,YanXu.CombinationtherapyofaninhibitorofgroupVIAphospholipaseA2withpaclitaxelishighlyeffectiveinblockingovariancancerdevelopment.AmJPathol.2011;179:452-61. 10.JussiPihlajamäki,CarlesLerin,PaulaItkonen,TannerBoes,ThomasFloss,JoshuaSchroeder,FarrellDearie,SarahCrunkhorn,FurkanBurak,JosepC.Jimenez-Chillaron,TiinaKuulasmaa,PekkaMiettinen,PeterJ.Park,ImadNasser,ZhenwenZhao,ZhaiyiZhang,YanXu,WolfgangWurst,HongmeiRen,AndrewJ.Morris,StefanStamm,AllisonB.Goldfine,MarkkuLaakso,MaryElizabethPatti.,ExpressionofthesplicingfactorgeneSFRS10isreducedinhumanobesityandcontributestoenhancedlipogenesis.CellMetab.2011;14:208-18. 11.ZhenwenZhao,MenggangYu,YanXu,DavidCrabb,SuthatLiangpunsakul,Ethanol-inducedalterationsinfattyacid-relatedlipidsinserumandtissuesinmice.AlcoholismClinicalandExperimentalResearch,2011,35:229-234. 12.ZhenwenZhao,YanXu,Anextremelysimplemethodforextractionoflysophospholipidsandphospholipidsfrombloodsamples.JLipidRes,2010,51:652-659.PMID:19783525. 13.HuiLi,ZhenwenZhao,GangWei,LiboYan,DongmeiWang,HongZhang,GeorgeEarlSandusky,JohnTurkandYanXu,GroupVIAphospholipaseA2inbothhostandtumorcellsisinvolvedinovariancancerdevelopment.FASEBJ.2010;24(10):4103-16. 14.Jian-MinWu,YanXu,NicholasJSkill,HongmiaoSheng,ZhenwenZhao,MenggangYu,RomilSaxena,andMaryAMaluccio.AutotaxinexpressionanditsconnectionwiththeTNF-alpha-NF-kappaBaxisinhumanhepatocellularcarcinoma.MolCancer.2010;9:71. 15.StellaFotopoulou,NikosOikonomou,ElenaGrigorieva,IoannaNikitopoulou,TriantafillosPaparountas,ArtemisThanassopoulou,ZhenwenZhao,YanXu,DimitrisL.Kontoyiannis,EumorphiaRemboutsika,VassilisAidinis.ATXexpressionandLPAsignallingarevitalforthedevelopmentofthenervoussystem.DevBiol.2010;339(2):451-64. 16.SuthatLiangpunsakul,MargaretS.Sozio,EricShin,ZhenwenZhao,YanXu,RuthA.Ross,YanZeng,andDavidW.Crabb.InhibitoryeffectofethanolonAMPKphosphorylationismediatedinpartthroughelevatedceramidelevels.AmJPhysiolGastrointestLiverPhysiol.2010;298(6):G1004-12. 17.Sung-JoKim,ZhongjianZhang,ArjunSaha,ChinmoySarkar,ZhenwenZhao,YanXu,AnilB.Mukherjee.Omega-3andomega-6fattyacidssuppressER-andoxidativestressinculturedneuronsandneuronalprogenitorcellsfrommicelackingPPT1.NeurosciLett.2010;479:292-6. 18.ZhenwenZhao,YanXu,AccuratemeasurementoflysophosphatidicacidbyESI-MS/MSinplasmasamplesrequirespre-separationoflysophosphatidylcholine.JChromB,2009,877:3739-3742. 19.HuiLi,DongmeiWang,HongZhang,KashifKirmani,ZhenwenZhao,RosemarySteimetz,andYanXu,Lysophosphatidicacidstimulatescellmigration,invasion,andcolonyformationaswellastumorigenesis/metastasisofmouseovariancancerinimmunocompetentmice.Mol.CancerTher.2009,8:1692-1701. 20.HuiLi,DongmeiWang,LisamShanjukumarSingh,MichaelBerk,HaiyanTan,ZhenwenZhao,RosemarySteinmetz,KashifKirmani,GangWei,YanXu,AbnormalitiesinOsteoclastogenesisandDecreasedTumorigenesisinMiceDeficientforOvarianCancerGprotein-CoupledReceptor1.PlosOne,2009;4:e5705. 21.DongmeiWang,ZhenwenZhao,AndreaCaperell-Grant,GongYang,SamuelC.Mok,JinsongLiu,RobertM.BigsbyandYanXu,S1Pdifferentiallyregulatesmigrationofhumanovariancancerandhumanovariansurfaceepithelialcells.Mol.CancerTher.2008;7:1993-2002. 22.AndrewMTager,PeterLaCamera,BarrySShea,GabrieleSCampanella,MoisésSelman,ZhenwenZhao,VasiliyPolosukhin,JohnWain,BanuAKarimi-Shah,NancyDKim,WilliamKHart,AnniePardo,TimothySBlackwell,YanXu,JeroldChunandAndrewDLuster,TheLysophosphatidicAcidReceptorLPA1LinksPulmonaryFibrosistoLungInjurybyMediatingfibroblastRecruitmentandVascularLeak.NatureMedicine2008,14,45–54. 23.ZhenwenZhao,YijinXiao,PaulElson,HaiyanTan,SarahJ.Plummer,MichaelBerk,PhyuPhyuAung,IanC.Lavery,JeanPaulAchkar,GrahamCaseyandYanXu,Plasmalysophosphatidylcholinelevels:potentialbiomarkersforcolorectalcancer.JClinOncology2007,25:2696-2701. 24.赵镇文,熊蕾,王振鹏,辛斌,胡伟华,熊少祥,壳聚糖的基质辅助激光解吸电离飞行时间质谱分析,分析化学2007;35:1025-1028. 25.LisamShanjukumarSingh,MichaelBerk,RhondaOates,ZhenwenZhao,HaiyanTan,YingJiang,AiminZhou,KashifKirmani,RosemarySteinmetz,DanielLindner,YanXu,OvariancancerGprotein-coupledreceptor1,anewmetastasissuppressorgeneinprostatecancer.J.NationalCancerInstitute.2007,99:1313-1327. 26.ShuZhang,ZhenwenZhao,LeiXiong,BinXin,WeihuaHu,ShaoxiangXiong,Anovelsamplepreparationmethodofmatrix-assistedlaserdesorption/ionizationtimeofflightmassspectrometryforpolystyrene.Chin.Chem.Letters2007;18:718-721. 27.王振鹏,赵镇文,辛斌,胡伟华,熊少祥,三苯胺偶氮化合物的MALDI—TOF质谱研究,质谱学报,2007;28(1):27-31. 28.刘健安,赵镇文,辛斌,胡伟华,熊少祥,有机硼化合物的质谱分析,分析化学,2007;35(8):1203-1206. 29.SuyingDong,ZhenwenZhaoandHuiminMa,CharacterizationofLocalPolarityandHydrophobicBindingSitesofâ-LactoglobulinbyUsingN-TerminalSpecificFluorescenceLabeling.J.ProteomeResearch,2006;5:27-31. 30.XiaoxianZhao,DongmeiWang,ZhenwenZhao,YingyiXiao,SaubhikSengupta,YijinXiao,RenliangZhang,KirstenLauber,SebastianWesselborg,LiFeng,TylerM.Rose,YueShen,JunjieZhang,GlennPrestwich,andYanXu,Caspase-3-dependentActivationofCalcium-independentPhospholipaseA2EnhancesCellMigrationinNon-apoptoticOvarianCancerCells.J.Biol.Chem2006;281:29357-29368. 31.JuanRen,Yi-jinXiao,LisamShanjukumarSingh,XiaoxianZhao,ZhenwenZhao,LiFeng,TylerM.Rose,GlennD.Prestwich,andYanXu,LysophosphatidicAcidIsConstitutivelyProducedbyHumanPeritonealMesothelialCellsandEnhancesAdhesion,Migration,andInvasionofOvarianCancerCells.CancerRes2006;66:3006-3014. 32.熊少祥,赵镇文,蒲丹,辛斌,王光辉,液相基质辅助激光解吸电离-傅里叶变换离子回旋共振质谱研究,分析化学,2004;32(1):14-18. 33.ZhenwenZhao,ShaoxiangXiong,XiangwenLiu,BinXinandGuanghuiWang.Matrix-AssistedLaserDesorption/IonizationTime-of-FlightMassSpectrometryStudiesofLowMolecularWeightDendrimers.EurJMassSpectrom.2003,9:203-211. 34.ShaoxiangXiong,ZhenwenZhao,BinXinandGuanghuiWang.CharacterizationofMacrocyclicPolysaccharidesUsingMatrix-AssistedLaserDesorption/IonizationTimeofFlightMassSpectrometry.RapidCommu.MassSpectrom.2003;17:1079-1083. 35.ShaoxiangXiong,QinxueDing,ZhenwenZhao,WenzhangChen,GuanghuiWangandShaojunLiu.ANewMethodtoImproveSensitivityandResolutioninMatrix-AssistedLaserDesorption/IonizationTime-of-FlightMassSpectrometry.Proteomics2003;3:265-272. 36.ZhikunWu,QingqiChen,ShaoxiangXiong,BinXin,ZhenwenZhao,LijinJiang,andJinShiMa.Double-StrandedHelicates,Triangles,andSquaresFormedbytheSelf-AssemblyofPyrrol-2-ylmethyleneaminesandZnIIIons.Angew.Chem.Int.Ed.2003;42:3271-3274.

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