姚立 - 中国科学院化学研究所 -

个人简介

1998年9月至2002年7月，武汉理工大学，学士（高分子材料与工程专业） 2003年9月至2008年6月，中国科学院化学研究所，博士（物理化学专业，导师：葛茂发研究员） 2008年8月2013年10月，美国休斯顿大学，博士后，（DepartmentofChemistry,Sponsor:Prof.ShoujunXu.） 2013年12月至今，中国科学院化学研究所，研究员，担任课题组长（分子动态与稳态结构实验室）在超低场磁探测技术、分子和细胞的磁成像及相互作用等化学生物学与生命分析化学研究领域做出了具有创新性的工作。通过高灵敏的光学原子磁力仪，开发磁性纳米颗粒物的定量成像技术和新型的磁基分子探测技术，研究分子和细胞的磁成像和生物分子间的相互作用。在J.Am.Chem.Soc.，Angew.Chem.Int.Ed.，Adv.Mater.等国际期刊现已发表SCI科研论文60余篇，申请发明专利10余项。

研究领域

纳米生物技术:超低场生物力谱及磁成像技术的发展高性能磁功能材料及超低场磁探针的设计、制备与功能开发重大疾病相关的核酸、蛋白等生物大分子及细胞（肿瘤细胞、细菌）的相互作用研究肿瘤转移、细胞力学信号转导的重要分子机理与调控机制

近期论文

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Qilong Li, Feng Feng, Min Xu, Yajing Liu, Mengmeng Li, Xueyan Feng, Xiuyu Wang,* Li Yao.* Multifunctional liquid microrobots based on paramagnetic microdroplets. Cell Rep. Phys. Sci. 2023, DOI:https://doi.org/10.1016/j.xcrp.2023.101279. Fengmin Yang, Dawei Yang, Lixia Wang, Qian Li,* Hong Zhang, Li Yao, Hongxia Sun,* Yalin Tang.* An inner salt derivative of Thioflavin T designed for live-cell imaging of mitochondrial G-quadruplexes. Sens. Actuators B Chem. 2023, 374, 1, 132820. Ranran Sun, Xiaomeng Guo, Dawei Yang, Xinchen Cai, Qian Li, Li Yao,* Hongxia Sun,* Yalin Tang.* RNA G-quadruplex in live cells lighted-up by a thiazole orange analogue for SCA36 identification. Int. J. Biol. Macromol. 2023, 229, 724-731. Yahong Chai, Qi Lou, Min Xu, Song Hong, Feng Feng, Yajing Liu, Qilong Li, Xueyan Feng, Hanzhang Xiao, Ao Chen, Xiuyu Wang,* Li Yao.* Modulation of Magnetic Exchange Coupling via Constructing Bi- or Multimagnetic Heterointerfaces. J. Phys. Chem. Lett. 2022, 13, 12082-12089. Guanhua Xu, Mengmeng Li, Qiyue Wang, Feng Feng, Qi Lou, Yi Hou, Junfeng Hui, Peisen Zhang, Li Wang, Li Yao,* Shijie Qin, Xiaoping Ouyang, Dazhuan Wu, Daishun Ling,* Xiuyu Wang.* A dual-kinetic control strategy for designing nano-metamaterials: novel class of metamaterials with both characteristic and whole sizes of nanoscale. Adv. Sci. 2022, 2205595. Yajing Liu, Xiuyu Wang,* Feng Feng, Qilong Li, Hanzhang Xiao and Li Yao.* Deformable, sensible, and reconfigurable microgels with structural color: potential as camouflage soft microrobots. J. Mater. Chem. C 2022, 10, 5070-5078. Xue Han, Qi Lou, Feng Feng, Guanhua Xu, Song Hong, Li Yao*, Shijie Qin, Dazhuan Wu, Xiaoping Ouyang, zhiguo Zhang, and Xiuyu Wang.* Spatiotemporal release of ROS and NO for overcoming biofilm heterogeneity. Angew. Chem. Int. Ed. 2022, e202202559. Mengxue Sun, Pan Lu, Chanchan Yu, Feng Feng, Qilong Li, Jinxiu Zhan, Min Xu, Yajing Liu, Li Yao.* Force-coded strategy for the simultaneous detection of multiple tumor-related proteins. Anal. Chem. 2022, 94, 25, 8992–8998. Shuyu Liao, Mengxue Sun, Jinxiu Zhan, Min Xu, Li Yao.* Advances in the biological application of force-induced remnant magnetization spectroscopy. Molecules 2022, 27, 2072. Min Xu, Xueyan Feng, Feng Feng, Hantao Pei, Ruping Liu, Qilong Li, Chanchan Yu, Di Zhang, Xiuyu Wang, Li Yao. * Magnetic nanoparticles for the measurement of cell mechanics using force-induced remnant magnetization spectroscopy. Nanoscale 2020, 12, 14573-14580. Jinxiu Zhan, Feng Feng, Min Xu, Li Yao,* Maofa Ge.* Progress in chemo–mechanical interactions between nanoparticles and cells. Acta Phys. -Chim. Sin. 2020, 36, 1905076. Feng Feng, Xueyan Feng, Di Zhang, Qilong Li, Li Yao.* Matrix stiffness induces pericyte-fibroblast transition through YAP activation. Front.Pharmacol. 2021, 12, 698275. Yahong Chai, Feng Feng, Qilong Li, Chanchan Yu, Xueyan Feng, Pan Lu, Xiuyu Wang,* Li Yao.* One-pot synthesis of high-quality bimagnetic core/shell nanocrystals with diverse exchange coupling. J. Am. Chem. Soc. 2019, 141, 3366-3370. Qilong Li, Haitao Chen, Xueyan Feng, Chanchan Yu, Feng Feng, Yahong Chai, Pan Lu, Tao Song, Xiuyu Wang,* Li Yao.* Nanoparticle-regulated semiartificial magnetotactic bacteria with tuneable magnetic moment and magnetic sensitivity. Small 2019, 15, 1900427. Xueyan Feng, Chanchan Yu, Feng Feng, Pan Lu, Yahong Chai, Qilong Li, Di Zhang, Xiuyu Wang, Li Yao.* Direct measurement of through-bond effects in molecular multivalent interactions. Chem. Eur. J. 2019, 25(12), 2978-2982. Chanchan Yu, Di Zhang, Xueyan Feng, Yahong Chai, Pan Lu, Qilong Li, Feng Feng, Xiuyu Wang, Yao Li.* Nanoprobe-based force spectroscopy as a versatile platform for probing the mechanical adhesion of bacteria. Nanoscale 2019, 11, 7648-7655. Di Zhang, Feng Feng, Ruping Liu, Wenjia Zhu, Li Yao.* Mechanochemistry in cancer cell metastasis. Chin. Chem. Lett. 2019, 30, 7-14. Hongbo Chen, Hongxia Sun,* Yahong Chai, Suge Zhang, Aijiao Guan, Qian Li, Li Yao,* Yalin Tang.* Insulin-like growth factor type I selectively binds to G-quadruplex structures. Biochim. Biophys. Acta Gen. Subj. 2019, 1863(1), 31-38. Pan Lu, Di Zhang, Yahong Chai, Chanchan Yu, XiuyuWang, Yalin Tang, Maofa Ge, Li Yao.* Regulatory-sequence mechanical biosensor: A versatile platform for investigation of G-quadruplex/label-free protein interactions and tunable protein detection. Anal. Chim. Acta 2019, 1045, 1-9.