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个人简介

张力,博士,教授,主要从事炎症损伤分子调控机制的研究。 学习工作经历: 1997.09~2002.07华中科技大学同济医学院本科 2002.09~2007.07华中科技大学同济医学院硕-博连读 2007.07~2009.10重庆医科大学讲师 2009.11~2014.08重庆医科大学副教授 2014.09~至今重庆医科大学教授

研究领域

主要从事炎症损伤分子调控机制的研究

主持科研项目: 1.国家自然科学基金项目(No.81071446),32万元,2011.01~2013.12 脂氧素A4代谢障碍与类风湿性关节炎滑膜血管新生失控的关联性及机制研究 2.国家自然科学基金项目(No.30900651),20万元,2010.01~2012.12 HAT/HDAC失衡与乙酰化修饰异常:急性肺损伤炎症失控新机制 3.重庆市高等学校青年骨干教师资助计划(渝教人[2011]31号),6万元,2013.01-2014.12 SIRT1:肺内炎症自限调节新分子及药物干预新靶点 4.重庆市科委自然科学基金项目(cstc2012jjA10041),2.5万元,2012.09-2015.09 SIRT1在急性肺损伤炎症失控中的保护作用及机制研究 5.重庆市教委科学技术研究项目(KJ090304),2万元,2009.01~2010.12(已结题) 炎症消退期核因子kappa-B多位点乙酰化修饰规律及其机制的研究 6.重庆医科大学优秀青年教师培育计划,8万元,2010.07~2012.06(已结题) 急性肺损伤中核因子kappaB乙酰化修饰规律及其与炎症转归的关联性研究

近期论文

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1.JingyuanWan,XiaGong,RongJiang,ZhuoZhang,LiZhang*.AntipyreticandAnti-inflammatoryEffectsofAsiaticosideinLipopolysaccharide-treatedRatthroughUp-regulationofHemeOxygenase-1.PhytotherapyResearch.DOI:10.1002/ptr.4838 2.JunXie,JingyuanWan,RongJiang,HongxuLu,XiaorongPeng,LiZhang*.Up-regulationofSirt1incarbontetrachloride-inducedacuteliverinjury.DrugandChemicalToxicology.2013,36(3):277-832012,DOI:10.3109/01480545.2012.710630 3.JunXie,XiaomingZhang,LiZhang*.NegativeregulationofinflammationbySIRT1.PharmacologicalResearch.2012,67(1):60-67 4.HongxuLu,JingyuanWan,RongJiang,JunXie,XiaorongPeng,LiZhang*.Sodiumbutyratepotentiatescarbontetrachloride-inducedacuteliverinjuryinmice.ToxicologyMechanismsandMethods.2012,22(8):648-55. 5.Xiao-MingZhang,Yu-PingJing,Meng-YingJia,LiZhang*.NegativetranscriptionalregulationofinflammatorygenesbygroupB3vitaminnicotinamide.MolecularBiologyReports.2012,39(12):10367-71. 6.XinyuDeng,KunweiWu,JingyuanWan,LongjiangLi,RongJiang,MengyingJia,YupingJing,LiZhang*Aminotriazoleattenuatedcarbontetrachloride-inducedoxidativeliverinjuryinmice.FoodandChemicalToxicology.2012,50(9):3073-3078. 7.HongmeiYuan,LongjiangLi,WeipingZheng,JingyuanWan,PuGe,HongzhongLi,LiZhang*.Antidiabeticdrugmetforminalleviatesendotoxin-inducedfulminantliverinjuryinmice.InternationalImmunopharmacology.2012,12(4):682-688 8.HongmeiYuan,JingyuanWan,LongjiangLi,PuGe,HongzhongLi,LiZhang*.TherapeuticbenefitsofthegroupB3vitaminnicotinamideinmicewithlethalendotoxemiaandpolymicrobialsepsis.PharmacologicalResearch.2012,65(3):328-337 9.LiZhang,ShengweiJin,ChangdongWang,RongJiang,JingyuanWan.Histonedeacetylaseinhibitorsattenuateacutelunginjuryduringcecalligationandpuncture-inducedpolymicrobialsepsis.WorldJSurg.2010,34(7):1676-83. 10.LiZhang,JingyuanWan,RongJiang,WeiweiWang,HuayuDeng,YiShen,WeipingZheng,YapingWang.ProtectiveeffectsofTrichostatinAonliverinjuryinsepticmice.HepatologyResearch.2009,39(9):931-938 11.LiZhang,Xiao-mingZhang,PingWu,Hong-ZhongLi,Sheng-WeiJin,Xiao-YanZhou,Yong-shengLi,Du-YunYe,Bang-guoChen,Jing-YuanWan.BML-111,alipoxinreceptoragonist,modulatestheimmuneresponseandreducestheseverityofcollagen-inducedarthritis.InflammationResearch.2008,57(4):157-162 12.LiZhang,Jing-YuanWan,PingWu,Sheng-WeiJin,Hong-ZhongLi,Xiao-YanZhou,WeiXiong,Du-YunYe.ProtectiveeffectsofBML-111,alipoxinA4receptoragonist,oncarbontetrachloride-inducedliverinjuryinmice.HepatologyResearch.2007,37(11):948-56 13.LiZhang,PingWu,Sheng-WeiJin,PingYuan,Jing-YuanWan,Xiao-YanZhou,WeiXiong,Du-YunYe.LipoxinA4negativelyregulateslipopolysaccharide-induceddifferentiationofRAW264.7murinemacrophagesintodendritic-likecells.ChineseMedicalJournal.2007,120(11):981-7 14.LiZhang,Hong-zhongLi,XiaGong,Fu-lingLuo,BinWang,NingHu,Chang-dongWang,ZhuoZhang,Jing-yuanWan.ProtectiveeffectsofAsiaticosideonacuteliverinjuryinducedbylipopolysaccharide/D-galactosamineinmice.Phytomedicine.2010,17(10):811-9 15.曾韬,张力*.丁酸钠对内毒素血症小鼠肺损伤的保护作用.生理学报.2012,64(3):308-312 16.彭小蓉,卢虹旭,刘娟,何菲,黎桂菊,谢军,陈黎,张力*.地塞米松对两种急性肝损伤模型小鼠的作用.基础医学与临床.2011,31(6):717-718 17.张力,万敬员,叶笃筠,邓华瑜,汪维伟,沈宜,王亚平.脂氧素受体激动剂BML-111减轻佐剂诱导的关节炎.中国药理学通报.2009,25(3):304-307 18.张力,万敬员,段红,罗福玲,代先坤.白介素-10表达上调介导脂氧素在急性肝损伤中的保护效应.医学分子生物学杂志.2008.5(3):225-228 19.张力,吴萍,万敬员,周晓燕,熊维,袁萍,李咏生,叶笃筠.脂氧素对JurkatT细胞增殖和白介素-2/白介素-2受体表达的影响.中国病理生理杂志.2008,24(1):162-164 20.张力,叶笃筠,吴萍,黄艳君,袁萍,万敬员,吴涛,周晓燕,金胜威.肾上腺素对小鼠巨噬细胞中促炎/抗炎介质比值的影响.中国病理生理杂志.2006,22(3):555-558 21.张力,叶笃筠,吴萍,万敬员,张代娟,吴涛,周晓燕.肾上腺素对脂多糖诱导的小鼠巨噬细胞炎症介质表达的影响.华中科技大学学报(医学版).2004,33(5):538-540 22.姚烽,汲广岩,张力*.AMPK:炎症调控新靶点.生理学报.2012,64(3):341-345 23.袁红梅,万敬员,张力*.促炎症消退新介质:消退素与保护素.生命科学.2012,24(1):54-57 24.何菲,刘娟,张力*.乙酰化——炎症调控新方式.生命的化学.2011,31(6):814-817 25.谢军,彭小蓉,张力*.炎症反应中的蛋白质翻译后修饰.医学分子生物学杂志.2010,7(5):459-462 26.张力.促炎症消退介质脂氧素与炎症性疾病.生命的化学.2008,28(6):752-754 27.张力,万敬员.脂氧素受体及其介导的促炎症消退信号.生命的化学.2007,27(6):545-547 28.张力,万敬员,叶笃筠.脂氧素与炎症消退.生命的化学.2004,24(1).61-63

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