徐小龙 - 中国科学技术大学 - 化学与材料科学学院

个人简介

1989.9 - 1992.3 中国科学技术大学应用化学系，硕士 1997.9 - 2000.6 中国科学技术大学化学系，博士 2000.7 - 2001.11 中国科学技术大学化学系，讲师 2001.12 - 至今中国科学技术大学化学系，副教授 2003.6 - 2005.8 加拿大生物技术研究所，NESRC Fellowship 获奖及荣誉 1994年安徽省自然科学论文一等奖 2000年中国科学技术大学郭沫若奖

研究领域

1．蛇毒蛋白的结构、性质和功能 2．金属离子与蛋白质相互作用 3．纳米材料的生物效应及其毒性机理

近期论文

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Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Yan Zhang, Dengke Shen, Lili Peng and Jiajia Song. Cu(II)- and disulfide bonds-induced stabilization during the guanidine hydrochloride- and thermal-induced denaturation of NAD-glycohydrolase from the venom of Agkistrodon zenci sikiş acutus. Metallomics, 2012, 4 (2), 166 -173. (cover paper) Hao Wu, Xiaolong Xu, Dengke Shen, Lili Peng, Jiajia Song,Yan Zhang. Binding of Ca2+ and Zn2+ to factor IX/X-binding protein from venom of Agkistrodon Halys Pallas: stabilization of the structure during GdnHCl- and thermal-induced denaturation. Journal of Biological Inorganic Chemistry, 2011, 16(1), 69-79. Dengke Shen, Xiaolong Xu, Hao Wu, Lili Peng, Yan Zhang, Jiajia Song, Qingde Su. Metal ion binding to anticoagulation factor II from the venom of Agkistrodon acutus: stabilization of the structure and regulation of the binding affinity to activated coagulation factor X. Journal of Biological Inorganic Chemistry, 2011, 16(4), 523-537. Lili Peng, Xiaolong Xu, Dengke Shen, Yan Zhang, Jiajia Song, Xincheng Yan, Mingchun Guo. Purification and characterization of a novel phosphodiesterase from the venom of Trimeresurus stejnegeri: inhibition of platelet aggregation. Biochimie, 2011, 93, 1601-1609. Dengke Shen, Xiaolong Xu, Liyun Zhang, Hao Wu, Lili Peng. Identification of a nitric oxide-dependent hypotensive effect of anticoagulation factor II from the venom of Agkistrodon acutus. Biochemical Pharmacology, 2010, 79(3), 498- 506. Xiaolong Xu, Liyun Zhang, Zhaofeng Luo, Dengke Shen, Hao Wu, Lili Peng, Jiajia Song and Yan Zhang. Metal ions binding to NAD-glycohydrolase from the venom of Agkistrodon acutus: regulation of multicatalytic activity, Metallomics, 2010, 2(7), 480-489. Xiaolong Xu, Liyun Zhang, Dengke Shen, Hao Wu, Lili Peng, Jiehua Li. Effect of metal ion substitutions in anticoagulation factor I from the venom of Agkistrodon acutus on the binding of activated coagulation factor X and on structural stability. Journal of Biological Inorganic Chemistry, 2009, 14(4), 559-571. Liyun Zhang, Xiaolong Xu, Zhaofeng Luo, Dengke Shen and Hao Wu. Identification of an unusual AT(D)Pase-like activity in multifunctional NAD- glycohydrolase from the venom of Agkistrodon acutus. Biochimie, 2009, 91(2), 240-251. Xiaolong Xu, Qingliang Liu, and Yongshu Xie. Metal ion-induced stabilization and refolding of anticoagulation factor II from the venom of Agkistrodon acutus. Biochemistry, 2002, 41(11), 3546-3554. Xiaolong Xu, Qingliang Liu, Huaming Yu and Yongshu Xie. Ca2+ and Tb(III)-induced stabilization and refolding of anticoagulation factor I from the venom of Agkistrodon acutus. Protein Science, 2002, 11(4), 944-956.