顾振华 - 中国科学技术大学 - 合肥微尺度物质科学国家研究中心

个人简介

Education and Employment 2012.1-Now Professor, University of Science and Technology of China, Department of Chemistry 2008.8-2011.12 Postdoctoral Fellow, University of California, Santa Barbara 2007.8-2008.7 Postdoctoral Fellow, University of California, Berkeley 2002.9-2007.6 Ph.D. Shanghai Institute of Organic Chemistry 1998.9-2002.6 B.A. Nanjing University Gu was born in Jiangsu, China. He studied chemistry at Nanjing University (China). In 2002 he pursued his Ph.D. studies with Professor Shengming Ma at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences. After postdoctoral research with Professor K. Peter C. Vollhardt at the University of California Berkeley, and with Professor Armen Zakarian at the University of California Santa Barbara in the field of natural total synthesis, he joined the University of Science and Technology of China in 2012. His research focused on the development of new transformations and their applications in total synthesis.

研究领域

Natural products synthesis is one of major research interests of our group. Complex molecule synthesis not only serves for the further biological and medicinal studies, but also provides new question and promotes the innovation of synthetic methods. Our group is interested in development of simple, novel methods and strategies that enable C-C, C-heteroatom bond formations and functionalization of unsaturated carbon-carbon bonds, and finally these new developed methods would be used in the total synthesis of highly functionalized natural products.

近期论文

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Base-Promoted Coupling of HFIP in Cu-Catalyzed Asymmetric Ring Opening of Cyclic Diaryliodoniums, Abdur Rahim, Biqiong Hong*, Zhenhua Gu*, J. Org. Chem., 2024 DOI:10.1021/acs.joc.4c02426. Coplanar Atropochiral 5H-Cyclopenta[2,1-b:3,4-b']dipyridine Ligands: Synthesis and Applications in Asymmetric Ring-Opening Reaction, Han Yang, Xiaojie Sun, Zhen Chen, Chenming Jiang, Longhui Duan, Jinbo Zhao, Zhenhua Gu*, Angew. Chem. Int. Ed., 2024,e202416839. DOI:10.1002/anie.202416839. Quaternary Chiral Phthalides Enabled by Dirhodium(II)/Phosphine Catalyzed Asymmetric Carbonyl Addition Cascade, Shuming Zhan, Heng Xu, Biqiong Hong*, Zhenhua Gu*, Org. Lett., 2024, 26,8023–8027 DOI:10.1021/acs.orglett.4c02765. Spatial decoupling of bromide-mediated process boosts propylene oxide electrosynthesis, Mingfang Chi, Jingwen Ke, Yan Liu, Miaojin Wei, Hongliang Li, Jiankang Zhao, Yuxuan Zhou, Zhenhua Gu, Zhigang Geng* and Jie Zeng*, Nat. Commun., 2024, 15, 3646. DOI:10.1038/s41467-024-48070-1. Symmetric Anion Mediated Dynamic Kinetic Asymmetric Knoevenagel Reaction for N−C and N−N Atropisomers Synthesis, Hongyu Qu, Chenyang Huo, Jimeng Ge, Xiaoping Xue*, Zhenhua Gu and Ruixian Deng*, Angew. Chem. Int. Ed., 2024, 63, e202410012. DOI:10.1002/anie.202410012. Kinetic Resolution of Helicenols via Palladium-Catalyzed Atroposelective C–C Bond Cleavage/Ring-Opening Reaction, Zhen Chen, Han Yang, Lin Li, Longhui Duan*, Junwei Xi, and Zhenhua Gu*, Org. Lett., 2024, 26,3429–3434 DOI:10.1021/acs.orglett.4c00962. Regio- and Atroposelective Ring-Opening of 1H-Benzo[4,5]oxazolopyridinones, Ruixian Deng*, Puyang Dong, Jimeng Ge, Wenjing Zhang, Xiaoping Xue, Longhui Duan, Linlin Shi*, Zhenhua Gu*, Angew. Chem. Int. Ed., 2024, 63, e202402231. DOI:10.1002/anie.202402231. Rapid synthesis of benzofulvenes from α-bromodiarylethylenes based on a 1,4-palladium shift strategy, Abdur Rahim, Shuming Zhan, Biqiong Hong, Longhui Duan and Zhenhua Gu*, Org. Chem. Front., 2024. DOI:10.1039/d3qo01846f. Conjugation-Induced Spin Delocalization in Helical Chiral Carbon Radicals via Through-Bond and Through-Space Effects, Longhui Duan, Xiaoping Xue,* Biqiong Hong, Zhenhua Gu*, Adv. Sci., 2023, 10, 202304563. DOI:10.1002/advs.202304563. Aryl ortho methoxylation, Kun Zhao and Zhenhua Gu, Nature Chem., 2023, 15, 1334-1335 . DOI:10.1038/s41557-023-01323-w. Preparation of Optically Active 2,2'-Dibromo-6,6'-diiodo -1,1'-biphenyl: A Powerful Precursor for Modular Synthesis of Functionalized Atropisomers, Yuanyuan Li, Longhui Duan, Biqiong Hong, and Zhenhua Gu*, Chin.J.Chem., 2023, 41, 3515-3520. DOI:10.1002/cjoc.202300438. Expanding the Potential of 3-Hydroxyindolinones:Synthesis of Quinoxalin-2(1H)-ones through Acid-Promoted Azidation and Ring-Expansion, Shuming Zhan, Heng Xu, Wenjing Guo, Lin Li, Biqiong Hong, and Zhenhua Gu*, Adv.Synth.Catal., 2023, 365, 3450-3454. DOI:10.1002/adsc.202300685. A Chiral Relay Race: Stereoselective Synthesis of Axially Chiral Biaryl Diketones through Ring-Opening of Optical Dihydrophenan-threne-9,10-diols, Lei Shi, Jiawei Zhu, Biqiong Hong, and Zhenhua Gu*, Molecules., 2023, 28, 5956. DOI:10.3390/molecules28165956. Synthesis of atropisomers via transition-metal-catalyzed enantioselective carbene transformations, Chongqing Pan* and Zhenhua Gu*, Trends in Chem., 2023, 5, 684-696. DOI:10.1016/j.trechm.2023.05.005. Stereoselective Synthesis Axially Chiral Arylnitriles through Base-Induced Chirality-Relay β-Carbon Elimination of α-Hydroxyl Ketoxime Esters, Xue Zhang, Xiaoping Xue, and Zhenhua Gu*, Org. Lett., 2023, 25, 3602-3606. DOI:10.1021/acs.orglett.3c00805. Confronting the Challenge of Asymmetric Carbonyl Addition to Sterically Bulky Isatins: Upgrading Dirhodium(II)/Biphosphine Catalytic System, Wenjing Guo, Shuming Zhan, Han Yang, and Zhenhua Gu*, Org. Lett., 2023, 25, 3281-3286. DOI:10.1021/acs.orglett.3c01028. Atroposelective Three-Component Coupling of Cyclic Diaryliodoniums and Sodium Cyanate Enabled by the Dual-Role of Phenol, Shan Yang, Tianze Zheng, Longhui Duan, Xiaoping Xue, and Zhenhua Gu*, Angew. Chem. Int. Ed., 2023, 62, e202302749. DOI:10.1002/anie.202302749. Dirhodium(II)/Phosphine Catalyst with Chiral Environment at Bridging Site and Its Application in Enantioselective Atropisomer Synthesis, Lei Shi, Xiaoping Xue, Biqiong Hong, Qigang Li and Zhenhua Gu*, ACS Central Sci., 2023, 9, 748-755. DOI:10.1021/acscentsci.2c01207. Divergent Synthesis of Helical Ketone Enabled by Rearrangement of Spiro Carbocation, Limin Wang, Longhui Duan, Biqiong Hong, and Zhenhua Gu*, Org. Lett., 2023, 25, 1912-1917. DOI:10.1021/acs.orglett.3c00424. Recent Progress in Cyclic Aryliodonium Chemistry: Syntheses and Applications, Xiaopeng Peng, Abdur Rahim, Weijie Peng, Feng Jiang, Zhenhua Gu* and Shijun Wen* , Chem. Rev., 2023, 123, 1364-1416. DOI:10.1021/acs.chemrev.2c00591. Two at the price of one: Kinetic resolution of multi-substituted metallocenes, Yuanyuan Li,Zhenhua Gu*, Sci. Bull., 2022, 67, 2502-2504 . DOI:10.1016/j.scib.2022.12.011. Synthesis of Atropisomers with Biaryl and Vinylaryl Chirality via Pd-Catalyzed Point-to-Axial Chirality Transfer Ring-Opening Reaction, Jian Gu, Biqiong Hong, Xiaoping Xue, Junwei Xi, and Zhenhua Gu*, Org. Lett., 2022, 24, 9097-9101. DOI:10.1021/acs.orglett.2c03760. Nitrenoid from Oxime: A Practical Synthesis of Planar Chiral Ferrocenyl Phenanthridines via Nitrene-Involved Ring-Expansion Reaction, Na Li,Biqiong Hong,Jinbo Zhao*,and Zhenhua Gu*, Angew. Chem.Int. Ed., 2023, 62, e202215530. DOI:10.1002/anie.202215530. From Peripheral Stereogenic Center to Axial Chirality: Synthesis of 3-Arylthiophene Atropisomers, Lin Li,Junwei Xi,Biqiong Hong,Zhenhua Gu*, Adv. Synth.Catal., 2022, 364, 1-7. DOI:10.1002/adsc.202200957. Synthesis of 2-Aryl Azetidines through Pd-Catalyzed Migration/Coupling of 3-Iodoazetidines and Aryl Boronic Acids, Han Yang, Zhen Chen, Wenjing Guo, and Zhenhua Gu*, Org. Lett., 2022, 24, 5731–5735. DOI:10.1021/acs.orglett.2c02152. Transition Metal-Catalyzed Biaryl Atropisomer Synthesis via a Torsional Strain Promoted Ring-Opening Reaction, Xue Zhang, Kun Zhao, and Zhenhua Gu*, Acc. Chem. Res., 2022, 55, 1620-1633. DOI:10.1021/acs.accounts.2c00175. Paddlewheel dirhodium(II) complexes with N-heterocyclic carbene or phosphine ligand: New reactivity and selectivity, Biqiong Hong, Lei Shi, Lin Li, Shuming Zhan, and Zhenhua Gu*, Green Synthesis and Catalysis., 2022, 3, 137-149. DOI:10.1016/j.gresc.2022.03.001. Atroposelective Kinetic Resolution of 8H-Indeno[1,2-c]thiophen-8-ols via Pd-Catalyzed C–C Bond Cleavage Reaction, Junwei Xi, Han Yang, Lin Li, Xue Zhang, Chunyu Li, and Zhenhua Gu*, Org. Lett., 2022, 24, 2387–2392. DOI:10.1021/acs.orglett.2c00642. Torsional strain inversed chemoselectivity in a Pd-catalyzed atroposelective carbonylation reaction of dibenzothiophenium, Qiuchi Zhang, Xiaoping Xue, Biqiong Hong, and Zhenhua Gu*, Chem. Sci. , 2022, 13, 3761-3765. DOI:10.1039/d2sc00341d. Synthesis of 2-Hydroxy-2′-aroyl-1,1′-biaryls via Oxidative Ring-Opening of 9H-Fluoren-9-ols, Xiaoping Xue, Biqiong Hong, Jia Feng, and Zhenhua Gu*, Org. Lett., 2021, 24, 496-500. DOI:10.1021/acs.orglett.1c03849. Construction of 2-Amino-2′-ketonyl Biaryls via Acid-Mediated Ring Opening of 9H-Fluoren-9-ols with Organic Azides, Shan Yang, Biqiong Hong, Jia Feng, and Zhenhua Gu*, Org. Lett., 2021, 23, 9179–9183. DOI:10.1021/acs.orglett.1c03484. Ring-Expansion Strategy for α-Aryl Azahelicene Construction: Building Blocks for Optoelectronic Materials, Jia Feng, Limin Wang, Xiaoping Xue, Zengyin Chao, Biqiong Hong, and Zhenhua Gu*, Org. Lett., 2021, 23, 8056–8061. DOI:10.1021/acs.orglett.1c03070. Synthesis of Planar Chiral 2-Aryl Aroylferrocenes via Palladium-Catalyzed C–C Bond-Cleavage/Ring-Opening Reaction, Zengyin Chao, Na Li, Biqiong Hong, Mingming Ma*, and Zhenhua Gu*, Org. Lett., 2021, 23, 7759−7764. DOI:10.1021/acs.orglett.1c02775. Construction of Axial Chirality and Silicon-Stereogenic Center via Rh-Catalyzed Asymmetric Ring-Opening of Silafluorenes, Xiufen Bi, Jia Feng, Xiaoping Xue, and Zhenhua Gu*, Org. Lett., 2021, 23, 3201−3206. DOI:10.1021/acs.orglett.1c00935. Enantioselective preparation of atropisomeric biaryl trifluoromethylsulfanes via ring-opening of cyclic diaryliodoniums, Longhui Duan, Zhonggui Wang, Kun Zhao and Zhenhua Gu*, Chem. Commun., 2021, 57, 3881–3884. DOI:10.1039/d1cc00171j. Atropisomerism in Styrene: Synthesis, Stability, and Applications, Jia Feng and Zhenhua Gu*, SynOpen, 2021, 05, 68-85. DOI:10.1055/s-0040-1706028. Transition‐Metal‐Catalyzed Carbon‐Carbon Bond Activation in Asymmetric Synthesis, Xiufen Bi, Qiuchi Zhang, and Zhenhua Gu*, Chin. J. Chem., 2021, ASAP. DOI:10.1002/cjoc.202000591. Diols Activation via Cu/Borinic Acids Synergistic Catalysis in Atroposelective Ring‐Opening of Cyclic Diaryliodoniums, Kun Zhao†, Shan Yang†, Qi Gong, Longhui Duan, and Zhenhua Gu*, Angew. Chem. Int. Ed., 2021, 60, 5788–5793. DOI:10.1002/anie.202014127 († K.Z. and S.Y. contributed equally to this work). Catalytic Asymmetric Synthesis of Atropisomeric Nitrones: Versatile Intermediate for Axially Chiral Biaryls, Wenjing Guo, Jian Gu, and Zhenhua Gu*, Org. Lett., 2020, 22, 7622–7628. DOI:10.1021/acs.orglett.0c02830 Catalytic asymmetric C–Si bond activation via torsional strain-promoted Rh-catalyzed aryl Narasaka acylation, Jia Feng†, Xiufen Bi†, Xiaoping Xue, Na Li, Lei Shi and Zhenhua Gu*, Nat. Commun., 2020, 11, 4449. DOI:10.1038/s41467-020-18273-3 († J. F. and X. B. contributed equally to this work). Cu-Catalyzed Site- and Enantioselective Ring-Opening of Cyclic Diaryliodoniums with 1,2,3-Triazoles, Zengyin Chao, Mingming Ma*, and Zhenhua Gu*, Org. Lett., 2020, 22, 6441–6446. DOI:10.1021/acs.orglett.0c02256 Atroposelective Ring Opening of Cyclic Diaryliodonium Salts with Bulky Anilines Controlled by a Chiral Cobalt(III) Anion, Xue Zhang, Kun Zhao, Na Li, Jie Yu*, Liu-Zhu Gong and Zhenhua Gu*, Angew. Chem. Int. Ed. , 2020, 59, 19899–19904. DOI:10.1002/anie.202008431 Palladium‐Catalyzed Atroposelective 16‐Membered Macrocyclization: Total Synthesis of Isoplagiochin D, Junwei Xi Zhenhua Gu*, Chin. J. Chem. , 2020, 38, 1081-1085. DOI:10.1002/cjoc.202000051 Hypervalent Iodine‐Mediated Carbon‐Carbon Bond Cleavage and Dearomatization of 9H-Fluoren-9-ols, Ruixian Deng, Shuming Zhan, Chunyu Li and Zhenhua Gu*, Angew. Chem. Int. Ed. , 2020, 59, 3093–3098. DOI:10.1002/anie.201913373