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个人简介

教育经历 Education 2006耶鲁大学分子、细胞及发育生物学系,博士 (导师:G.ShirleenRoeder,美国科学院院士) Ph.D.,Molecular,CellularandDevelopmentalBiology,YaleUniversity 2001耶鲁大学分子、细胞及发育生物学系,硕士 M.S.,Molecular,CellularandDevelopmentalBiology,YaleUniversity 1999北京大学生命科学学院,学士 B.S.,CollegeofLifeSciences,PekingUniversity,China 荣誉 Awards 2017北京市首届高等学校青年教学名师 2017首都师范大学优秀教师 2017首都师范大学最受学生喜爱导师 2017首都师范大学十大影响力师门 2017首都师范大学优秀主讲教师 2016北京市教委市属高校“创想杯”多媒体课件制作与微课程应用大奖赛三等奖 2016首都师范大学优秀主讲教师 2015教育部全国高校教师网络培训中心主办全国高校微课教学比赛教学设计奖 作品:《细胞周期》 2015首都师范大学优秀主讲教师 2012北京市高等教育教学成果奖一等奖(排名第三) 2011首都师范大学首届青年教师优秀教学奖 2011首都师范大学2011届本科生毕业论文(设计)优秀指导教师 2011第七届北京市青年教师教学基本功比赛二等奖 2010霍英东教育基金会第十二届高等院校青年教师奖三等奖 2009首都师范大学青年教师教学基本功竞赛一等奖,最佳教案奖 2007北京市科技新星 1999-2006耶鲁大学━香港范氏奖学金(FanFellowship) 1998北京大学光华奖奖学金 工作经历 ProfessionalExperience 2018.1-今首都师范大学教授 Professor,CNU 2009.1-今首都师范大学生科院细胞生物学教学团队队长 Director,CellBiologyTeachingGroup,CNU 2008.9-2012.12首都师范大学生科院院长助理 DeanAssistant,CollegeofLifeSciences,CNU 2008.1-2017.12首都师范大学副教授 AssociateProfessor,CNU 2007.5-2007.12首都师范大学讲师 AssistantProfessor,CNU 2006.4-2006.7耶鲁大学分子、细胞及发育生物学系,博士后 PostdoctoralAssociate,MCDB,YaleUniversity

近期论文

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1.ShanshanNai1,YingxinShi1,HuanweiRu1,YueheDing,QizhiGeng,ZheLi,Meng-QiuDong,XingzhiXuandJingLi*2019Chk2-dependentphosphorylationofmyosinphosphatasetargetingsubunit1(MYPT1)regulatescentrosomematuration.CellCycledoi:10.1080/15384101.2019.1654795 2.XueHan1,BinPeng1,Bei-BeiXiao1,S.-LiCao*,Chao-RuiYang,Wen-ZhuWang,Fu-ChengWang,Hong-YunLi,Xiao-LiYuan,RuifengShi,JiLiao,HailongWang,JingLi,XingzhiXu*.2019Synthesisandevaluationofchalconeanaloguescontaininga4-oxoquinazolin-2-ylgroupaspotentialanti-tumoragents.EuropeanJournalofMedicinalChemistry.162:586-601 3.CaifeiLiuandJingLi*2018O-GlcNAc:asweetheartofthecellcycleandDNAdamageresponse.FrontiersinEndocrinology(Invited)9:415. 4.XiaomeiHu1,ZheLi1,YueheDing,QizhiGeng,ZhikaiXiahou,HuanweiRu,Meng-QiuDong,XingzhiXuandJingLi*.2018Chk1modulatestheinteractionbetweenmyosinphosphatasetargetingprotein1(MYPT1)andproteinphosphatase1cβ(PP1cβ).CellCycle.17(4):421–427 5.Chao-ruiYang1,BinPeng1,Sheng-LiCao*,Ting-tingRen,WeiJiang,Fu-ChengWang,You-ShanLi,GuoWang,ZhengLi,ShibinXu,JiLiao,HailongWang,JingLi,XingzhiXu*.2018.Synthesis,cytotoxicevaluationandtargetidentificationofthieno[2,3-d]pyrimidinederivativeswithadithiocarbamatesidechainatC2position.EuropeanJournalofMedicinalChemistry,154:324-340 6.XiaoluMa1,HongmeiLiu1,JingLi1,YihaoWang,YueheDing,HongyanShen,YeranYang,ChenyiSun,MinHuang,YingfengTu,YangLiu,YongliangZhao,MengqiuDong,PingXu,Tie-ShanTang*,CaixiaGuo*2017PolηO-GlcNAcylationgovernsgenomeintegrityduringtranslesionDNAsynthesis.NatureCommunications.8(1):1941.(1EqualContributions) 7.JieTian1,YingxingShi1,ShanshanNai,QizhiGeng,Lei-LiangZhang,Gong-HongWei,XingzhiXu*andJingLi*.2017.Ataxin-10isinvolvedinGolgimembranedynamics.JournalofGeneticsandGenomics.44(11):549-552 8.ZheLi1,XueyanLi1,ShanshanNai,QizhiGeng,JiLiao,XingzhiXu*andJingLi*.2017Checkpointkinase1-inducedphosphorylationofO-Linkedβ-N-Acetylglucosaminetransferaseregulatestheintermediatefilamentnetworkduringcytokinesis.JournalofBiologicalChemistry.292(48)19548–19555 9.XueyanLi,ShanshanNai,YueheDing,QizhiGeng,BingtaoZhu,KaiYu,Wei-GuoZhu,Meng-QiuDong,Xiao-DongSu,XingzhiXu*andJingLi*.2017Polo-likekinase1(PLK1)-dependentphosphorylationofmethylenetetrahydrofolatereductase(MTHFR)regulatesreplicationviahistonemethylation.CellCycle16(20):1933-1942 10.LiYS,PengB,MaL,CaoSL,BaiLL,YangCR,WanCQ,YanHJ,DingPP,LiZF,LiaoJ,MengYY,WangHL,LiJ,XuX.2017Synthesis,crystalstructuresandantitumoractivityoftwoplatinum(II)complexeswithmethylhydrazinecarbodithioatederivativesofindolin-2-one.EurJMedChem.127:137-146. 11.JingLi*andXingzhiXu*.2016DNAdouble-strandbreakrepair:ataleofpathwaychoices.ActaBiochimicaetBiophysicaSinica.48(7):641-6. 12.JieTian1,QizhiGeng1,YueheDing,JiLiao,Meng-QiuDong,XingzhiXu*andJingLi*.2016O-GlcNAcylationantagonizesphosphorylationofCdh1(CDC20homologue1).JournalofBiologicalChemistry.291(23):12136-44. 13.DingPP,GaoM,MaoBB,CaoSL,LiuCH,YangCR,LiZF,LiaoJ,ZhaoH,LiZ,LiJ,WangH,XuX.2016.Synthesisandbiologicalevaluationofquinazolin-4(3H)-onederivativesbearingdithiocarbamatesidechainatC2-positionaspotentialantitumoragents.EurJMedChem.108:364-73 14.JieTian,ChuanTian,YueheDing,ZheLi,QizhiGeng,ZhikaiXiahou,JueWang,WenyaHou,JiLiao,Meng-QiuDong,XingzhiXuandJingLiAuroraB-dependentphosphorylationofAtaxin-10promotestheinteractionbetweenAtaxin-10andPlk1incytokinesis.ScientificReports.:8360 15.ZhaoH,ZhuM,DouG,ZhaoH,ZhuB,LiJ,LiaoJ,XuX.BCL10regulatesRNF8/RNF168-mediatedubiquitinationintheDNAdamageresponse.2014CellCycle.13(11):1777-87. 16.JingLi1,*,XiaoqianLiu1,JiLiao,JieTian,JueWang,XinWang,JiezhongZhangandXingzhiXu*.2013.MYPT1sustainscentromericcohesionandthespindle-assemblycheckpoint.JournalofGeneticsandGenomics.40(11):575-8. 17.JinpingLiu,LinliXu,JianingZhong,JiLiao,JingLiandXingzhiXu.2012.ProteinphosphatasePP4isinvolvedinNHEJ-mediatedrepairofDNAdouble-strandbreaks.CellCycle11(14),2643-49(CommentaryonCellCycle11(14),2590) 18.JinpingLiu,ShukunLuo,HongchangZhao,JiLiao,JingLi,ChunyingYang,BoXu,DavidF.Stern,XingzhiXu*andKeqiongYe*.2012.Structuralmechanismofthephosphorylation-dependentdimerizationofMDC1forkhead-associateddomain.NucleicAcidsResearch40(9):3898-3912(featuredarticle) 19.LiJ1,*.,Wang,J1.,Hou,W1.,Jing,Z.,Tian,C.,Han,Y.,Liao,J.,Dong,M-Q.,Xu,X*.2011.PhosphorylationofAtaxin-10bypolo-likekinase1isrequiredforcytokinesis.CellCycle10(17):2946–2958(coverarticle) 20.ZhongJ,LiaoJ,LiuX,WangP,LiuJ,HouW,ZhuB,YaoL,WangJ,LiJ,StarkJM,XieY,XuX.2011ProteinphosphatasePP6isrequiredforhomology-directedrepairofDNAdouble-strandbreaks.CellCycle10(9):1411-1419 21.Lv,S.,Bu,W.,Jiao,H.,Liu,B.,Zhu,L.,Zhao,H.,Li,J.,Liao,J.,Xu,X.2010.LSD1isrequiredforchromosomesegregationduringmitosis.Eur.J.CellBiol.89(7):557-63 22.Li,J*.,Wang,J.,Jiao,H.,Liao,J.,andXu,X*.2010.Cytokinesisandcancer:PololovesROCK’n’Rho(A).Journalofgeneticsandgenomics37(3):159-172 23.Wang,H.,Zhao,A.,Chen,L.,Zhong,X.,Liao,J.,Gao,M.,Cai,M.,Lee,D.H.,Li,J.,Chowdhury,D.,Yang,Y.G.,Pfeifer,G.P.,Yen,Y.,andXu,X.2009.HumanRIF1encodesananti-apoptoticfactorrequiredforDNArepair.Carcinogenesis30(8):1314-1319 24.Zhang,X.,Liu,D.,Lv,S.,Wang,H.,Zhong,X.,Liu,B.,Wang,B.,Liao,J.,Li,J.,PfeiferG.P.,andXu,X.2009.CDK5RAP2isrequiredforspindlecheckpointfunction.CellCycle8(8):1206-1216. 25.Wang,B.,Zhao,A.,Sun,L.,Zhong,X..Zhong,J.,Wang,H.,Cai,M.,Li,J.,Xu,Y.,Liao,J.,Sang,J.,Chowdhury,D.,Pfeifer,G.P.,Yen,Y.,andXu,X.2008.ProteinphosphatasePP4isoverexpressedinhumanbreastandlungtumors.CellResearch18:974-977 26.Li,J.,Agarwal,S.,andRoeder,G.S.2007SSP2andOSW1,Twosporulation-specificgenesinvolvedinsporemorphogenesisinSaccharomycescerevisiae.Genetics.175(1):143-154 27.Li,J.,Hooker,G.W.,andRoeder,G.S.2006.SaccharomycescerevisiaeMer2,Mei4andRec114formacomplexrequiredformeioticdouble-strandbreakformation.Genetics,173(4):1969-1981 28.HuafeiLu,XiaotianMing,LijiaQu,MeihuaLiu,JingLi,HongyaGu,ZhangliangChen.2000.Constructionofchimericinduciblepromotersbyelicitorsofricefungalblastpathogenandtheirexpressionintransgenicrice.ChineseScienceBulletin,45(3):242-246

学术兼职

2017-今《中国生物化学与分子生物学报》英文编辑 2017国自然生物三处函评专家 2016美国阿尔茨海默研究基金Alzheimer’sAssociationResearchGrant(AARG) 函评专家 2015-今《遗传》英文润色编辑 2013.10北京市科学技术研究院青年骨干评审专家 2013教育部“留学回国人员科研启动基金”评审专家 2012国自然生物五处函评专家

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