李夏璐 - 首都师范大学 - 生命科学学院

个人简介

教育经历 2000年中国科学院上海生物化学研究所分子生物学博士 1995年复旦大学生物化学系生物化学学士工作经历 2012年12月-首都师范大学特聘教授 2006年-2012年12月北京生命科学研究所研究员 2005-2006年美国哥伦比亚大学生物系助理研究员 2000-2005年美国哥伦比亚大学生物系博士后目前实验室正在开展的工作包括： 1.R-loop破坏基因组不稳定性的应对机制 2.转录在肿瘤发生以及肿瘤细胞染色体不稳定性建立过程中的作用 3.染色体脆性表达的分子机理 4.哺乳动物细胞中停顿复制叉的稳定和重新启动的分子机制 5.人基因组DNA复制起始的时、空调控机制 6.RNA加工过程在癌症发生和发展中的作用欢迎对上述科学问题感兴趣的同学加入本实验室（接受调剂生）。

研究领域

1.基因组稳定性 2.基因表达调控 3.DNA复制 4.RNA加工

近期论文

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1.YiWei,FanYang,ChuanliTuju,JieLiu,YonggongZhaiandX.Li*,Molecular basisfortheexpressionofchromosomefragility(*correspondingauthor)(in preparation) 2.B.Liang,P.Peng,S.Chen,L.Lin,D.Cao,J.Yang,H.Li,T.Gui,X.Li*and K.Shen*Characterizationandproteomicanalysisofovariancancer-derived exosomes,JournalofProteomics,80(2013)171-182(*correspondingauthor) 3.W.Jin,Z.Niu,D.XuandX.Li*,RBM5promotesexon4skippingofAIDpre-mRNA bycompetingwiththebindingofU2AF65tothepolypyrimidinetract,FEBSLett 586(2012)3852-3857.(*correspondingauthor) 4.Z.Niu,W.Jin,L.Zhang,X.Li*,TumorsuppressorRBM5directlyinteractswith theDExD/H-boxproteinDHX15andstimulatesitshelicaseactivity,FEBSLett 586(2012)977-983.(*correspondingauthor)(timescited:3) 5.Y.Kanehiro,K.Todo,M.Negishi,J.Fukuoka,W.Gan,T.Hikasa,Y.Kaga,M. Takemoto,M.Magari,X.Li,J.L.Manley,H.Ohmori,N.Kanayama, Activation-inducedcytidinedeaminase(AID)-dependentsomatichypermutation requiresaspliceisoformoftheserine/arginine-rich(SR)proteinSRSF1,Proc NatlAcadSciUSA109(2012)1216-1221.(Selectedbyfaculty1000ofbiology) (timescited:5) 6.W.Gan,Z.Guan,J.Liu,T.Gui,K.Shen,J.L.Manley,X.Li*,R-loop-mediated genomicinstabilityiscausedbyimpairmentofreplicationforkprogression, Genes&Development,25(2011)2041-2056.(*correspondingauthor)(Selectedby faculty1000ofbiology)(timescited:19) 7.X.LiandJamesL.Manley,2009,TheRoleofAlternativeSplicingDuringthe CellCycleandProgrammedCellDeath.InRalphA.BradshawandEdwardA.Dennis, editors:HandbookofCellSignaling2ndedition,Oxford:AcademicPress,,pp. 2329-2334.(invitedbookchapter) 8.X.Li*,TianhuiNiu.,andJamesLManley.2007.TheRNAbindingproteinRNPS1 alleviatesASF/SF2depletion-inducedgenomicinstability.RNA13(12):2108-2115 (*correspondingauthor).(timescited:11) 9.X.LiandJamesLManley,2006,Co-transcriptionalprocessesandtheirinfluence ongenomestability.Genes&Development,2006;20(14):1838-1847.(timescited: 63) 10.X.LiandJamesLManley.2006.AlternativeSplicingandControlofApoptotic DNAFragmentation.CellCycle5(12).1286-1288.(timescited:5) 11.X.LiandJamesL.Manley,2005,Newtalentsforanoldacquaintance:theSR proteinsplicingfactorASF/SF2functionsinthemaintenanceofgenomestability. Cellcycle,4(12):1706-1708.(timescited:19) 12.X.Li,JinWangandJamesLManley,2005,LossofsplicingfactorASF/SF2induces G2cell-cyclearrestandapoptosis,butinhibitsinternucleosomalDNA fragmentation,Genes&Development,19(22):2705-2714.(timescited:76) 13.X.LiandJamesLManley,2005,InactivationoftheSRproteinsplicingfactor ASF/SF2resultsingenomicinstability.Cell,122(3),p365-378.(Selectedby faculty1000ofbiology)(timescited:214) 14.BoliangLi,X.Lietal.,1999,Humanacyl-CoA:Cholesterolacyltransferase-1 (ACAT-1)geneorganizationandevidencethatthe4.3-kilobaseACAT-1mRNAis producedfromtwodifferentchromosomes,JBiolChem,274(16): p11060-11071.(timescited:109)