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个人简介

工作经历 2005-至今 郑州大学化学与分子工程学院 教授 2007-至今 郑州大学河南省化学生物与有机化学重点实验室副主任 2010-至今 郑州大学化学与分子工程学院硕士生导师、博士生导师 2006-2007 美国南加州大学药物化学系访问学者 1998-2005 郑州大学化学系 副教授 硕士生导师 1987-2000 河南医科大学基础部教师 学习经历 1983-1987 郑州大学化学系本科学习 1996-1997 英国瑞丁大学化学系留学 2001-2004 郑州大学化学系博士研究生

研究领域

实验室长期从事有机合成方法学的研究工作,在有机合成新方法、绿色有机合成、绿色催化、可见光催化、有机磷化学等研究领域取得了突出的研究成果。 探索和开辟了系列构建C-P键,C-C键,C-S键,C-N键,C-O键的新型有机合成新方法 (1)开发了多种自由基引发的串联环化反应合成系列多环特别是杂环功能有机化合物的高效合成新方法。 (2)以H-亚磷酸酯作为优异的合成前体,在构建C-P键化合物以及实现氮杂环的选择性官能团化方面展现了具有重要的理论意义及应用价值的学术成绩,在磷化学合成方法领域做出了突出贡献。 (3)设计并成功合成了一系列以含1,2,3-三氮唑五元杂环等新型双膦酸类化合物及其荧光标记物,并深入开展了相关生物活性的检测,此研究对于新型双膦酸类化合物合成和进一步的开发应用奠定基础。 (4)在天然产物的分离、提取及结构鉴定、天然产物与药物分子的磷酰化结构改造、小分子与大分子相互作用等方面开展了出色的工作

近期论文

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Fan Gao, Kai Sun,* Xiao-Lan Chen,* Tao Shi, Xiao-Yun Li, Ling-Bo Qu, Yu-Fen Zhao, Bing Yu*,Visible-light-induced Phosphorylation of Imidazo-fused Heterocycles under Metal-free Conditions,J. Org. Chem., 2020, 85(22), 14744-14752. (Invited Paper) Ya-Feng Si,# Kai Sun,# Xiao-Lan Chen,* Xiao-Yang Fu, Yan Liu, Fan-Lin Zeng, Tao Shi, Ling-Bo Qu, Bing Yu*, Arylaminomethyl radical-initiated cascade annulation reaction of quinoxalin-2(1H)-ones catalyzed by recyclable photocatalyst perovskite, Org. Lett., 2020, 22(17), 6960-6965. Link Fan-Lin Zeng, Qi-Yan Lv, Xiao-Lan Chen* and Bing Yu*, Recent Advances of Calcium Carbide in Organic Reactions. Curr. Chin. Chem., 2020, DOI: 10.2174/2666001601999200817111836. Link Ya-Feng Si, Xiao-Lan Chen,* Xiao-Yang Fu, Kai Sun, Xiaojie Song, Ling-Bo Qu, and Bing Yu*, Divergent g-C3N4-catalyzed reactions of quinoxalin-2(1H)-ones with N-aryl glycines under visible light: Solvent-controlled hydroaminomethylation and annulation. ACS Sustainable Chem. Eng., 2020, 8(29), 10740-10746. Link Xiao-Yun Li#, Yan Liu#, Xiao-Lan Chen,* Xin-Yuan Lu, Xing-Xing Liang, Shan-Shan Zhu, Chuan-Wan Wei, Ling-Bo Qu, and Bing Yu*, 6π-Electrocyclization in Water: Microwave-Assisted Synthesis of Polyheterocyclic-Fused Quinoline-2-Thiones. Green Chem., 2020, 22(14), 4445-4449. Link Mehwish Hussain Muhammad, Xiao-Lan Chen,* Yan Liu, Tao Shi, Yuyu Peng, Lingbo Qu, and Bing Yu*, Recyclable Cu@C3N4-catalyzed hydroxylation of aryl boronic acids in water under visible-light: Synthesis of phenols under ambient condition and room temperature. ACS Sustainable Chem. Eng., 2020, 8, 7, 2682-2687. Link Tao Shi,# Kai Sun,# Xiao-Lan Chen,* Zhao-Xin Zhang, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Recyclable Perovskite as Heterogeneous Photocatalyst for Aminomethylation of Imidazo-fused Heterocycles. Adv. Synth. Catal., 2020, 362, 362(11), 2143-2149. Link Shuai-Qi He, Xiao-Lan Chen,* Fan-Lin Zeng, Pei-Pei Lu, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Promoted Oxidative Decarboxylation of Arylacetic Acid in Air: Metal-Free Synthesis of Aldehydes and Ketones at Room Temperature. Chin. Chem. Lett., 2020, 31, 31(7), 1863-1867. Link Yan Liu,# Shi-Jun Li,# Xiao-Lan Chen,* Lu-Lu Fan, Xiao-Yun Li, Shan-Shan Zhu, Ling-Bo Qu, and Bing Yu*, Mn(III)-Mediated Regioselective 6-endo-trig Radical Cyclization of o-Vinyl Arylisocyanides to Access 2-Functionalized Quinolines. Adv. Synth. Catal., 2020, 362(3), 688-694. Link Kai Sun, Xiao-Lan Chen,* Yin-Li Zhang, Hui-Fang Su, Qiu-Chen Peng, Bing Yu*, Ling-Bo Qu, Kai Li*, A kind of atypical AIEgens used for one-photon/two-photon targeted-imaging in live cells. ACS Appl. Bio Mater., 2020, 3(1), 505-511. Link Xiao-Ceng Liu, Xiao-Lan Chen,* Yan Liu, Kai Sun, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-Light-Induced Metal-Free Synthesis of 2‑Phosphorylated Thioflavones in Water. ChemSusChem, 2020, 13(2), 298-303. Link Kai Sun,# Ya-Feng Si,# Xiao-Lan Chen,* Qi-Yan Lv, Yu-Yu Peng, Ling-Bo Qu and Bing Yu*, Synthesis of Phosphoryl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones from 2-Arylbenzoimidazoles and Diarylphosphine Oxides. Asian J. Org. Chem., 2019, 8, 2042-2045. Link Fan-Lin Zeng,# Kai Sun,# Xiao-Lan Chen,* Xiao-Ya Yuan, Shuai-Qi He, Yan Liu, Yu-Yu Peng, Ling-Bo Qu, Qi-Yan Lv, and Bing Yu*, Metal-Free Visible-Light Promoted Radical Cyclization to Access Perfluoroalkyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones and Indolo[2,1-a]isoquinolin-6(5H)-ones. Adv. Synth. Catal., 2019, 361, 5176-5181. Link Kai Sun, Xiao-Lan Chen,* Yin-Li Zhang, Kai Li*, Xian-Qiang Huang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Metal-free Sulfonyl Radical-initiated Cascade Cyclization to Access Sulfonated Indolo[1,2-a]quinolines. Chem. Commun., 2019, 55, 12615-12618. Link Rui Li#, Tao Shi#, Xiao-Lan Chen,* Qi-Yan Lv, Yin-Li Zhang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Visible-light-promoted organic dyes-catalyzed sulfidation and phosphorylation of arylhydrazines toward aromatic sulfides and diphenylphosphoryl hydrazides. New J. Chem., 2019, 43, 13642-13646. Link Kai Sun#, Ya-Feng Si#, Xiao-Lan Chen,* Qi-Yan Lv, Nan Jiang, Shan-Shan Wang, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Silver-Catalyzed Radical Cascade Cyclization of Unactivated Alkenes towards Cyclopenta[c]quinolines. Adv. Synth. Catal., 2019, 361, 4483-4488. Link Xiao-Ceng Liu#, Kai Sun#, Qi-Yan Lv, Xiao-Lan Chen,* Yuan-Qiang Sun, Yu-Yu Peng, Ling-Bo Qu, and Bing Yu*, Silver-Mediated Radical Phosphorylation/Cyclization of N-Allylbenzamides to Access Phosphoryl-Substituted Dihydroisoquinolones. New J. Chem., 2019, 43, 12221-12224. Link Xiao-Ceng Liu#, Kai Sun#, Xiao-Lan Chen,* Wen-Fei Wang, Yan Liu, Qian-Li Li, Yu-Yu Peng, Ling-Bo Qu and Bing Yu*, Visible-Light-Promoted Transition-Metal-Free Approach toward Phosphoryl-Substituted Dihydroisoquinolones via Cascade Phosphorylation/Cyclization of N-Allylbenzamides. Adv. Synth. Catal., 2019, 361, 3712-3717. Link Yan Liu, Xiao-Lan Chen,* Kai Sun, Xiao-Yun Li, Fan-Lin Zeng, Xiao-Ceng Liu, Ling-Bo Qu, Yufen Zhao and Bing Yu*, Visible-Light Induced Radical Perfluoroalkylation/Cyclization Strategy to Access 2-Perfluoroalkylbenzothiazoles/benzoselenazoles by EDA Complex. Org. Lett., 2019, 21(11), 4019-4024. Link Yin-Li Zhang,# Kai Sun,# Qi-Yan Lv, Xiao-Lan Chen,* Ling-Bo Qu, and Bing Yu*, Recent Applications of Radical Cascade Reaction in the Synthesis of Functionalized 1-Indenones. Chin. Chem. Lett., 2019, 30(7), 1361-1368. Link Fan-Lin Zeng, Xiao-Lan Chen,* Shuai-Qi He, Kai Sun, Yan Liu, Rui Fu, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Copper-Catalyzed One-Pot Three-Component Thioamination of 1,4-Naphthoquinone. Org. Chem. Front., 2019, 6, 1476-1480. Link Junchao Wang,# Kai Sun,# Xiaolan Chen,* Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, An External-catalyst-free Trifluoromethylation/cyclization Strategy to Access Trifluoromethylated-Dihydroisoquinolinones/Indolines with Togni Reagent II. Org. Lett., 2019, 21, 1863-1867. Link Kai Sun, Shi-Jun Li, Xiao-Lan Chen,* Yan Liu, Xian-Qiang Huang, Dong-Hui Wei*, Ling-Bo Qu, Yu-Fen Zhao, and Bing Yu*, Silver-Catalyzed Decarboxylative Radical Cascade Cyclization toward Benzimidazo[2,1-a]isoquinolin-6(5H)-ones. Chem. Commun., 2019, 55(19), 2861-2864. Link Chunfeng Jing, Xiaolan Chen,* Kai Sun, Yongkang Yang, Tong Chen, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*, Copper-Catalyzed C4-H Regioselective Phosphorylation/Trifluoromethylation of Free 1-Naphthylamines. Org. Lett., 2019, 21(2), 486-489. Link Mehwish Hussain Muhammad, Xiao-Lan Chen*, Bing Yu*, Ling-Bo Qu, and Yu-Fen Zhao. Applications of H-Phosphonates for C Element Bond Formation. Pure Appl. Chem., 2019, 91(1), 33-41. (Invited Review) Link PAC2019.pdf1539602283484884.png Rui Li, Xiaolan Chen*, Shengkai Wei, Kai Sun, Lulu Fan, Yan Liu, Lingbo Qu, Yufen Zhao, and Bing Yu*. A visible-light-promoted metal-free strategy towards arylphosphonates: organic-dye-catalyzed phosphorylation of arylhydrazines with trialkylphosphites. Adv. Synth. Catal. 2018, 360, 4807-4813. Link Kai Sun, Xiaolan Chen*, Shi-Jun Li, Dong-Hui Wei, Xiao-Ceng Liu, Yin-Li Zhang, Yan Liu, Lu-Lu Fan, Ling-Bo Qu, Bing Yu*, Kai Li, Yuan-Qiang Sun, and Yu-Fen Zhao. Copper-Catalyzed Radical Cascade Cyclization to Access 3-Sulfonated Indenones with AIE Phenomenon. J. Org. Chem., 2018, 83, 14419-14430. Link Hao Hu, Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao.Silver-Catalyzed Radical Cascade Cyclization toward 1,5-/1,3-Dicarbonyl Heterocycles: An Atom-/Step-Economical Strategy Leading to Chromenopyridines and Isoxazole-/Pyrazole-Containing Chroman-4-Ones. Org. Lett., 2018, 20, 6157-6160. Link Hao Hu, Xiaolan Chen*, Kai Sun, Junchao Wang, Yan Liu, Hui Liu, Bing Yu*, Yuanqiang Sun, Lingbo Qu, and Yufen Zhao, Silver-catalyzed decarboxylative cascade radical cyclization of tert-carboxylic acids and o-(allyloxy)arylaldehydes towards chroman-4-one derivatives. Org. Chem. Front., 2018, 5(20), 2925-2929. Link Yan Liu, Xiao-Lan Chen*, Fan-Lin Zeng, Kai Sun, Chen Qu, Lu-Lu Fan, Zi-Long An, Rui Li, Chun-Feng Jing, Sheng-Kai Wei, Ling-Bo Qu, Bing Yu*, Yuan-Qiang Sun, and Yu-Fen Zhao, Phosphorus Radical-initiated Cascade Reaction to Access 2-Phosphoryl Substituted Quinoxalines, J. Org. Chem., 2018, 83, 11727-11735. Link Wen Zhu Bi, Chen Qu, Xiao Lan Chen*, Sheng Kai Wei, Ling Bo Qu, Shu Yun Liu, Kai Sun, Yu Fen Zhao, Copper(II) catalyzed heterobenzylic C(sp3)-H activation: Two efficient halogenation methodologies towards heterobenzyl halides, Tetrahedron, 2018, 74(15), 1908-1917. Link

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