近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang SQ, Kulp DW, Schramm CA, Mravic M, Samish I, DeGrado WF. The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions. Structure. In Press. Zhang Y, Bartz R, Grigoryan G, Bryant M, Aaronson J, Beck S, Innocent N, Klein L, Procopio W, Tucker T, Jadhav V, Tellers DM, DeGrado WF. Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation. ACS Chem Biol. In Press. Joh NH, Wang T, Bhate MP, Acharya R, Wu Y, Grabe M, Hong M, Grigoryan G, DeGrado WF. De novo design of a transmembrane Zn²⁺-transporting four-helix bundle. Science. 2014 Dec 19; 346(6216):1520-4. Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel. J Am Chem Soc. 2014 Dec 31; 136(52):17987-95. Gianti E, Carnevale V, DeGrado WF, Klein ML, Fiorin G. Hydrogen-Bonded Water Molecules in the M2 Channel of the Influenza A Virus Guide the Binding Preferences of Ammonium-Based Inhibitors. J Phys Chem B. 2014 Nov 11; In Press. Dong H, Fiorin G, DeGrado WF, Klein ML. Proton release from the histidine-tetrad in the M2 channel of the influenza A virus. J Phys Chem B. 2014 Nov 6; 118(44):12644-51. Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J. Specific aromatic foldamers potently inhibit spontaneous and seeded Aß42 and Aß43 fibril assembly. Biochem J. 2014 Nov 15; 464(1):85-98. Dong H, Fiorin G, DeGrado WF, Klein ML. Proton release from the histidine-tetrad in the m2 channel of the influenza a virus. J Phys Chem B. 2014 Nov 6; 118(44):12644-51. Gonzalez G, Hannigan B, DeGrado WF. A real-time all-atom structural search engine for proteins. PLoS Comput Biol. 2014 Jul; 10(7):e1003750. Molnar KS, Bonomi M, Pellarin R, Clinthorne GD, Gonzalez G, Goldberg SD, Goulian M, Sali A, DeGrado WF. Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ. Structure. 2014 Sep 2; 22(9):1239-51. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aß prion strains producing different amyloid deposits in bigenic mice. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10329-34. Rey-Carrizo M, Barniol-Xicota M, Ma C, Frigolé-Vivas M, Torres E, Naesens L, Llabrés S, Juárez-Jiménez J, Luque FJ, DeGrado WF, Lamb RA, Pinto LH, Vázquez S. Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus. J Med Chem. 2014 Jul 10; 57(13):5738-47. Ghosh A, Wang J, Moroz YS, Korendovych IV, Zanni M, DeGrado WF, Gai F, Hochstrasser RM. 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel. J Chem Phys. 2014 Jun 21; 140(23):235105. Mensa B, Howell GL, Scott R, DeGrado WF. Comparative Mechanistic Studies of Brilacidin, Daptomycin, and the Antimicrobial Peptide LL16. Antimicrob Agents Chemother. 2014 Sep; 58(9):5136-45. Pavone V, Zhang SQ, Merlino A, Lombardi A, Wu Y, Degrado WF. Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron. Nat Commun. 2014; 5:3581. Rufo CM, Moroz YS, Moroz OV, Stöhr J, Smith TA, Hu X, Degrado WF, Korendovych IV. Short peptides self-assemble to produce catalytic amyloids. Nat Chem. 2014 Apr; 6(4):303-9. Montalvo GL, Zhang Y, Young TM, Costanzo MJ, Freeman KB, Wang J, Clements DJ, Magavern E, Kavash RW, Scott RW, Liu D, Degrado WF. De novo design of self-assembling foldamers that inhibit heparin-protein interactions. ACS Chem Biol. 2014 Apr 18; 9(4):967-75. Polishchuk AL, Cristian L, Pinto LH, Lear JD, Degrado WF. Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein. Biochim Biophys Acta. 2014 Apr; 1838(4):1082-7. Montalvo GL, Gai F, Roder H, Degrado WF. Slow Folding-Unfolding Kinetics of an Octameric ß-Peptide Bundle. ACS Chem Biol. 2014 Jan 17; 9(1):276-81. Markiewicz BN, Jo H, Culik RM, Degrado WF, Gai F. Assessment of local friction in protein folding dynamics using a helix cross-linker. J Phys Chem B. 2013 Nov 27; 117(47):14688-96.