个人简介

Born Xi’an, Shaanxi, China, 1980. Fudan University, Shanghai, China, B.S. 2001, M.S. 2004. Harvard University, A.M. 2007, Ph.D. 2010. Massachusetts Institute of Technology and Children’s Hospital Boston, postdoctoral scholar, 2010-2012. University of Chicago, Assistant Professor, July 2012 - current. Accolades 2015, Kavli Frontiers of Science Fellow 2015, AFOSR Young Investigator Program Award 2014, Certificate of Appreciation, SPARK Summer Research Internship Program 2013, Certificate for Exceptional Teaching, Stanford University 2013, Searle Scholars Award 2013, National Science Foundation CAREER Award 2012, TR35 honoree, MIT Technology Review 2011, IUPAC Prize for Young Chemists 2010, Third Place in National Collegiate Inventors Competition 2009, Dudley R. Herschbach Teaching Award, Harvard University 2009, ACS Division of Inorganic Chemistry Young Investigator Award 2008, MRS Graduate Student Award

研究领域

Inorganic Chemistry/Physical Chemistry/Materials/Nanoscience/Biophysics

The Tian group is dedicated to an interdisciplinary view of science, taking inspiration from a variety of fields, including physical chemistry, materials science, chemical biology, biophysics, and engineering. The Tian group is interested in probing the molecular-nano interface between biological and semiconductor systems, placing an emphasis on novel material synthesis and device concept. This interest is focused around three primary goals: (1) Synthetic Cellular Interactions: Our group is interested in both imitating cellular behavior using semiconductor nanomaterials and the augmentation of existing biological systems with semiconductor components. We hope to stably incorporate inorganic materials into the pre-existing cellular frameworks, examining both how single cells interact with these new artificial components, and what uniquely inorganic properties (e.g., electrical and optoelectronic responses, bioorthogonality) we can exploit to derive a more nuanced control over these cellular systems. There are several motivations for pursuing this type of research. First, it has been shown that the extracellular environment can have a significant impact on cell morphogenesis and on the initiation of cellular signaling processes. We hope that by incorporating semiconductor nanomaterials into this environment we can use the physical properties of these materials to influence cell morphogenesis and motility. Additionally, we are interested in examining how cellular systems will adapt to nonliving semiconductor nanomaterials, both intra- and extracellularly. Cells communicate via a variety of methods, including biochemical and biophysical signaling. We hope to either artificially mimic or assist in these types of cellular behavior by incorporating semiconductor frameworks, elucidating these forms of cellular responses. Recognizing how cells incorporate or exclude these types of semiconductor frameworks will help us further understand the fundamental limits in the biophysical signal transductions between biological and synthetic systems, and could lead to innovative therapeutic pathways. (2) Nanoelectronic Exploration of Cellular Systems: The ability to monitor the electrophysiology of living cells in real time with good spatiotemporal resolution is crucial for advancing our knowledge of cellular signaling pathways. However, minimally invasive intracellular or intercellular recordings, have been difficult to obtain as traditional techniques use probes that are too large to leave the cell membrane intact or to allow for satisfactory spatiotemporal resolution. Similarly, the rigidity of many of these devices prevents them from easily interfacing with soft biological systems. Our group is interested in developing original solutions to overcome these obstacles, allowing for improved intracellular or intercellular recordings. (3) Development of Biomimetic Nanoscale Materials and Devices: Nature routinely uses proteins to design complex three dimensional structures at nanometer scales with great precision. While traditional organic synthesis methods have yielded excellent specificity in chemical products, these are typically limited to molecular length scales and the difficulty of synthesizing these products increases exponentially with size and functional composition. However, as inorganic nanomaterial synthesis methods improve, scientists and engineers are able to utilize these techniques for designing novel nanoscale systems of length scales comparable to natural systems, allowing for unique interactions. Additionally, biological systems are capable of a large degree of morphological and synthetic control, achieving these transformations under relatively benign conditions. We are interested in probing these types of systems, utilizing naturally inspired processes for semiconductor material synthesis. Finally, biological systems exhibit many unique properties not commonly observed in semiconductor materials such as homeostatic regulation and environmental adaptability. We are interested in exploring analogs to these types of behaviors in semiconductor systems, and examining how these insights can be applied towards new material and device designs for applications in regenerative medicine

近期论文

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J. Zimmerman, R. Parameswaran and B. Z. Tian, Nanoscale Semiconductor Devices as New Biomaterials. Biomaterials Science, 2014, in press. (invited review as one of the Emerging investigators in Biomaterials) B. Z. Tian and C. M. Lieber, Synthetic nanoelectronic probes for biological cells and tissue. Annual Review of Analytical Chemistry, 2013, 6, 31-51. (invited review) B. Z. Tian, "Nanowire Field Effect Transistors for Electrical Interfacing with Cells and Tissue", in "One-Dimensional Nanostructures, Principles and Applications" (eds. T. Y. Zhai and Y. N. Yao), John Wiley & Sons Inc., 2013. B. Z. Tian*, J. Liu*, T. Dvir*, L. H. Jin, J. H. Tsui, Q. Qing, Z. G. Suo, R. Langer, D. S. Kohane and C. M. Lieber, Macroporous nanowire nanoelectronic scaffolds for synthetic tissues, Nature Mater., 2012, 11, 986-994. (This work represents the first example of minimally invasive integration of semiconductor electronics with engineered tissues in 3D. It is potentially a new platform for drug screening, prosthetics and biological cybernetics. It is one of the Annual Highlights in 2012 by C&EN.) R. Gao, S. Strehle, B. Z. Tian, T. Cohen-Karni, P. Xie, X. J. Duan, Q. Qing and C. M. Lieber, Outside looking in: Nanotube transistor intracellular sensors, Nano Lett., 2012, 12, 3329-3333. X. J. Duan, R. X. Gao, P. Xie, T. Cohen-Karni, Q. Qing, H. S. Choe, B. Z. Tian, X. C. Jiang and C. M. Lieber, Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor. Nature Nanotech., 2012, 7, 174-179. B. Z. Tian and C. M. Lieber, Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes, Pure Appl. Chem., 2011, 83, 2153-2169. (invited review) C. Weldon, B. Z. Tian, D. S. Kohane, Nanotechnology for surgeons, WIREs Nanomed Nanobiotechnol, 2011, 3, 223-228. (invited review) T. Cohen-Karni, B. Z. Tian and C.M. Lieber, 揈lectrical recording from cardiac cells and tissue using nanowire transistors�, in "Nanomedicine and the Cardiovascular System" (eds. R. J. Hunter and V. R. Preedy), Science Publishers, 2011. B. Z. Tian*, T. Cohen-Karni*, Q. Qing, X. J. Duan, P. Xie and C. M. Lieber, Three-dimensional, flexible nanoscale field-effect transistors as localized bioprobes, Science, 2010, 329, 830-834. (This work represents a paradigm change in intracellular electrophysiology since 1950s. It is one of the Annual Highlights in 2010 by C&EN.) Q. Qing*, S. K. Pal*, B. Z. Tian*, X. J. Duan, B. P. Timko, T. Cohen-Karni, V. N. Murthy and C. M. Lieber, Nanowire transistor arrays for mapping neural circuits in acute brain slices, Proc. Natl. Acad. Sci. USA, 2010, 107, 1882-1887. B. P. Timko, T. Cohen-Karni, Q. Qing, B. Z. Tian and C. M. Lieber, Design and implementation of functional nanoelectronic interfaces with biomolecules, cells and tissue using nanowire device arrays, IEEE Trans. Nanotechnol., 2010, 9, 269-280. (invited review) B. Z. Tian, P. Xie, T. J. Kempa, D.C. Bell and C. M. Lieber, Single crystalline kinked semiconductor nanowire superstructures, Nature Nanotechnol., 2009, 4, 824-829. (cover highlight) B. Z. Tian, T. J. Kempa and C. M. Lieber, Single nanowire photovoltaics, Chem. Soc. Rev., 2009, 38, 16-24. (invited review) (inside cover highlight) Y. J. Dong, B. Z. Tian, T. J. Kempa and C. M. Lieber, Coaxial group III-nitride nanowire photovoltaics, Nano Lett., 2009, 9, 2183-2187. B. P. Timko*, T. Cohen-Karni*, G. H. Yu, Q. Qing, B. Z. Tian and C. M. Lieber, Electrical recording from hearts with flexible nanowire device arrays, Nano Lett., 2009, 9, 914-918. T. J. Kempa*, B. Z. Tian*, D. R. Kim, J.S. Hu, X. L. Zheng and C. M. Lieber, Single and tandem axial p-i-n nanowire photovoltaic devices, Nano Lett., 2008, 8, 3456-3460. J. Zheng, Y. Ding, B. Z. Tian, Z. L. Wang and X.W. Zhuang, Luminescent and Raman active silver nanoparticles with polycrystalline structure, J. Am. Chem. Soc., 2008, 130, 10472-10473. H.-G. Park, C. J. Barrelet, Y. N. Wu, B. Z. Tian, F. Qian and C. M. Lieber, A wavelength-selective photonic-crystal waveguide coupled to a nanowire light source, Nature Photon., 2008, 2, 622-626. W. I. Park, G. F. Zheng, X. C. Jiang, B. Z. Tian and C. M. Lieber, Controlled synthesis of millimeter-long silicon nanowires with uniform electronic properties, Nano Lett., 2008, 8, 3004-3009. Pre 2008 B. Z. Tian*, X. L. Zheng*, T. J. Kempa, Y. Fang, N.F. Yu, G.H. Yu, J.L. Huang and C.M. Lieber, Coaxial silicon nanowires as solar cells and nanoelectronic power sources, Nature, 2007, 449, 885-888. (This work represents the first study of photovoltaics at the single nanostructure level. It is one of the Annual Highlights in 2007 by C&EN.) B. Z. Tian, X. Y. Liu, L. A. Solovyov, Z. Liu, H. F. Yang, Z. D. Zhang, S. H. Xie, F. Q. Zhang, B. Tu, C. Z. Yu, O. Terasaki and D. Y. Zhao, Facile synthesis and characterization of novel mesoporous and mesorelief oxides with gyroidal structures, J. Am. Chem. Soc., 2004, 126, 865-875. (Ranked #4 CORE PAPER in "Mesoporous Materials" research field (1998-2008)as rated by ScienceWatch in Thomson Reuters) B. Z. Tian, X. Y. Liu, B. Tu, C. Z. Yu, J. Fan, L. M. Wang, S. H. Xie, G. D. Stucky and D. Y. Zhao, Self-adjusted synthesis of ordered stable mesoporous minerals by acid-base pairs, Nature Mater., 2003, 2, 159-163. (cover highlight) B. Z. Tian, X. Y. Liu, H. F. Yang, S. H. Xie, C. Z. Yu, B. Tu and D. Y. Zhao, General synthesis of ordered crystallized metal oxide nanoarrays replicated by microwave-digested mesoporous silica, Adv. Mater., 2003, 15, 1370-1374. (Ranked #2 CORE PAPER in "Mesoporous Materials" research field (1998-2008)as rated by ScienceWatch in Thomson Reuters)