Ramachandran, P. V. - Purdue University

个人简介

1974 B. Sc. University of Calicut, India 1976 M. Sc. University of Calicut, India 1983 Ph. D. Organic Chemistry, Indian Institute of Technology, Kanpur, India 1983-1984 Postdoctoral Research Associate, Department of Chemistry, IIT Kanpur 1984-1987 Postdoctoral Research Associate, Department of Chemistry, Purdue University 1987-1997 Research Scientist, Department of Chemistry, Purdue University 1997-2003 Assistant Professor, Department of Chemistry, Purdue University

研究领域

Our interests are firmly rooted in the application of organoborane and fluoro-organic chemistry. We develop novel methods and reagents to facilitate the synthesis of a variety of complex molecular targets, particularly for the treatment of cancer, inflammation, and central nervous system disorders. We also focus on the mechanistic aspects of our methodologies. One of our recent accomplishments is the borane-mediated convergent total synthesis of the tubulin-polymerizing potent anti-cancer molecule, (-)-dictyostatin. Our current efforts focus on the preparation of fluorinated analogs of dictyostatin via novel fluorinated crotylborating agents as well as borane-mediated aldol reactions. Our tandem allylboration-Cope rearrangement and allylboration-Prins cyclization strategies are also emerging as powerful tools for total synthesis. Our collaborative research setting encompasses biological aspects as well. At present, we have a number of compounds that are ligands for a variety of targets. For example, our fluorinated dictyostatin molecules are being examined for tubulin poylmerization and several of our novel g-butyro- and d-valerolactones are being examined for both COX- and NFkB Inhibition in collaboration with Indiana University School of Medicine. We have developed new procedures and reagents for allylboration of imines for the one-pot synthesis of optically active amines and amino acids including GABA analogs. We are presently investigating the properties of these de novo molecules generated by our initiatives by screening them for biological activity on ion channels and dopamine receptors through collaborations with the Medicinal Chemistry Department and the National Institute of Drug Abuse. Development of novel set of racemic and chiral GABA analogs will be assayed for activity as potential lead compounds for development as drugs for the treatment of epilepsy, neuropathic pain, and addiction.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Effects of gabapentin on cocaine self-administration, cocaine-triggered relapse and cocaine-enhanced nucleus accumbens dopamine in rats. Peng, X. Q.; Li, X.; Li, J.; Ramachandran, P. V.; Gagare, P. D.; Pratihar, D.; Ashby, C. R.; Gardner, E. L.; Xi, Z. X. Drug and Alcohol Dependence, 2007, 00, 0000. Synthesis of (E)- and (Z)-r-Alkylidene-g-aryl-g-butyrolactones via Alkenylalumination of Oxiranes Ramachandran. P. V.; Garner, G.; Pratihar, D. Org. Lett. 2007, 9, 4753-56. Preparative-scale Synthesis of 3,3,3-Trifluoropropene Oxide. Ramachandran, P. V.; Padiya, K. J. J. Fluorine Chem. 2007, 128, 1255–59. Preparation of Ammonia Borane in High Yield and Purity, Methanolysis and Regeneration. Ramachandran, P. V.; Gagare, P. D. Inorg. Chem. 2007, 46, 7810-17. Convenient Synthesis of Stable Aldimine-Borane Complexes, Chiral ?-Amino Alcohols, and g-Substituted GABA Analogs from Nitriles. Ramachandran, P. V.; Biswas, D. Org. Lett. 2007, 9, 3025-27. Acidity-Directed Synthesis of Substituted g-Butyrolactones from Aliphatic Aldehydes. Ramachandran, P. V.; Pratihar, D. Org. Lett. 2007, 9, 2087-90. The Influence of Fluorine on the Asymmetric Reduction of Fluoromethyl Ketones. Ramachandran, P. V.; Gong, B. Q.; Teodorovic, A. V. J. Fluorine Chem. 2007, 128, 844-50. Asymmetric Hydroboration and Matteson Homologation of for the Preparation of Fluorinated a-Phenethanols. Ramachandran, P. V.; Jennings, M. P. J. Fluorine Chem. 2007, 128, 827-31. Total Synthesis of Potential Antitumor Agent, (-)-Dictyostatin, Ramachandran, P. V.; Srivastava, A.; Hazra, D. Org. Lett. 2007, 9, 157-160. Synthesis of Fluorinated Glutamic Acid Derivatives via Vinylalumination, Ramachandran, P. V.; Madhi, S.; O’Donnell, M. J. J. Fluorine Chem. 2007, 128, 78-83. Acute and Repeated Administration of Fluoxetine, Citalopram and Paroxetine Significantly Alter the Activity of Midbrain Dopamine Neurons in Rats: An In Vivo Electrophysiological Study, Sekine, Y.; Suzuki, K.; Ramachandran, P. V. Blackburn, T.; Ashby, C. R.* Synapse, 2007, 61, 72-77. Heat of reaction measurements of sodium borohydride alcoholysis and hydrolysis. Zhang J.; Fisher, T. S*.; Gore, J. P.; Hazra, D.; Ramachandran, P. V.* Int. J. Hydrogen Energy 2006, 31, 2292-98. Control of Stereochemistry: A General Synthesis of cis- or trans-b,g-Disubstituted-g-butyrolactones following Z-crotylboration, Ramachandran, P. V.; Pratihar, D.; Biswas, D. Org. Lett. 2006, 8, 3877-80. Regioselective Hydroboration-oxidation and -amination of Fluoro-substituted Styrenes. Ramachandran, P. V.; Madhi, S.; O’Donnell, M. J. J. Fluorine Chem. 2006, 127, 1252-55. Catalytic Enantioselective Synthesis of Glutamic Acid Derivatives via Tandem Conjugate Addition-Elimination of Activated Allylic Acetates under Chiral PTC Conditions. Ramachandran, P. V.; Madhi, S.; Bland-Berry, L.; Reddy, M. V. R.; O’Donnell, M. J. J. Am. Chem. Soc. 2005, 127, 13450-51. Chiral Synthesis of Functionalized Tetrahydropyridines: -Aminobutyric Acid Uptake Inhibitor Analogues. Ramachandran, P. V.; Burghardt, T. E.; Bland-Berry, L.; J. Org. Chem., 2005; 70, 7911-7918. Studies Towards the Synthesis of Epothilone A via Organoboranes. Ramachandran, P. V.; Chandra, J. S; Prabhudas, B.; Pratihar, D.; Reddy, M. V. R.. Org. Biomol. Chem., 2005, 3, 3812 - 3824 Asymmetric Allylboration of a,b-Enals as a Surrogate for the Enantioselective Synthesis of Allylic Amines and α-Amino Acids. Ramachandran, P. V.; Burghardt, T. V.; Reddy, M. V. R. J. Org. Chem. 2005, 70, 2329-2931. Synthesis of 4-Substituted Homoallylic Alcohols via a One-pot Tandem Lewis-Acid Catalyzed Crotylboration-[3,3]-Sigmatropic Rearrangement. Ramachandran, P. V.; Pratihar, D.; Biswas, D. Chem. Commun. 2005, 1988-1989. Highly Diastereoselective and Enantioselective Preparation of Homoallylic Amines. Application for the Synthesis of β-Amino Acids and g-Lactams. Ramachandran, P. V.; Burghardt, T. V.. Chem. Eur. J. 2005, 4387-4395.