吴起 - 浙江大学

个人简介

浙江大学化学系，有机化学与药物化学研究所。副教授，博士生导师德国马普学会煤炭研究所访问学者浙江大学新星计划、国家留学基金资助人员浙江大学求是青年学者学习工作经历 1994.9-1998.7 四川大学应用化学系本科学习，毕业获理学学士学位 1998.9-2000.3 浙江大学化学系硕士研究生 2000.3-2003.3 浙江大学化学系博士研究生，毕业获理学博士学位 2005.2-至今浙江大学化学系，副教授 2008.9-2010.9 德国马普煤炭所（Max-Planck-Institut für Kohlenforschung）国家留学基金访问学者

研究领域

化学生物学蛋白质工程生物催化

近期论文

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J. Xu#, Y. Peng#, Z. Wang, Y. Hu, J. Fan, H. Zheng, X. Lin, Q. Wu*, Exploiting Cofactor Versatility to Convert a FAD Dependent Baeyer−Villiger Monooxygenase into a Ketoreductase, Angew. Chem. Int. Edit. 2019, DOI: 10.1002/ange.2019076062. Y. Zhang, B. Xia, Y.J. Hu, Q.Y. Zhu, X.F. Lin,* and Q. Wu*, Enantiocomplementary Chiral Polyhydroxyenoate: Chemoenzymatic Synthesis and Helical Structure Control, ACS Macro Lett, 2019, DOI: 10.1021/acsmacrolett.9b00527 B. Xia#, Y. Zhang#, Q. Zhu, X. Lin, Q. Wu*, Enzymatic synthesis and stereocomplex formation of chiral polyester containing long-chain aliphatic alcohol backbone, Biomacromolecules, 2019, DOI: 10.1021/acs.biomac.9b00918. Y.J. Hu, J. Xu, Y. Cen, D. Li, Y. Zhang, M. Huang,* X. Lin, Q. Wu*, Customizing the Enantioselectivity of a Cyclohexanone Monooxygenase by a Strategy Combining “Size-probes” with in silico Study. Chemcatchem 2019,DOI: 10.1002/cctc.201901200. Y. Cen, W. Singh, M. Arkin, T.S. Moody, M. Huang,* J. Zhou,* Q. Wu,* M.T. Reetz,* Artificial Cysteine-Lipases with High Activity and Altered Catalytic Mechanism Created by Laboratory Evolution Nature Comm. 2019, 10(1), 3198. Y. Zhang, Q. Zhu, Z. Fei, X. Lin, B. Xia,* Q. Wu*, Stereoselectivity-tailored chemo-enzymatic synthesis of enantiocomplementary poly (ω-substituted-δ-valerolactone) enabled by engineered lipase European Polymer Journal. 2019, 119, 52-60 J. Xu, # Y.X. Cen,# W. Singh, J. Fan, L. Wu, X.F. Lin, J.H. Zhou*, M. Huang*, M. T. Reetz*, & Q. Wu*, Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers J. Am. Chem. Soc. 2019, 141(19):7934-7945. J. Xu, Y. Hu, J. Fan, M. Arkin, D. Li, Y. Peng, W. Xu, X. Lin & Q. Wu*, Light-Driven Kinetic Resolution of α-Functionalized Carboxylic Acids Enabled by Engineered Fatty Acid Photodecarboxylase, Angew. Chem. Int. Edit. 2019, 58, 8474-8478. Yixin Cen,# Danyang Li,# Jian Xu, Qiongsi Wu, Qi Wu,* and Xianfu Lin,* Highly Focused Library-Based Engineering of Candida antarctica Lipase B with (S)-Selectivity Towards sec-Alcohols Adv. Synth. Catal. 2019, 361, 126-134 Yujing Hu, Jie Wang, Yixin Cen, He Zheng, Meilan Huang*, Xianfu Lin and Qi Wu,* “Top’’ or ‘‘bottom’’ switches of a cyclohexanone monooxygenase controlling the enantioselectivity of the sandwiched substrate Chem. Commun., 2019, 55, 2198-2201 Jian Xu, Mamatjan•Arkin, Yongzhen Peng, Weihua Xu, Huilei Yu, Xianfu Lin and Qi Wu,* Enantiocomplementary Decarboxylative Hydroxylation Combining Photocatalysis and Whole-Cell Biocatalysis in One-pot Cascade Process Green Chemistry, 2019, 21, 1907–1911 Yiru Liang, Yu Zhang, Yujing Hu, Bo Xia, Xianfu Lin and Qi Wu* Lipase-catalyzed synthesis of chiral poly(ester amide)s with an alternating sequence of hydroxy acid and L/D-aspartate units Polym. Chem., 2018, 9, 1412–1420 Bo Xia,†,‡ Jian Xu,‡ Zhiwei Xiang,‡ Yixin Cen, Yujing Hu, Xianfu Lin, and Qi Wu* Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita−Baylis−Hillman Acetates Using an Engineered Lipase−Organic Base Cocatalyst ACS Catal. 2017, 7, 4542−4549 Xiao-Yang Chen,‡ Yu-Jing Hu,‡ Tao Hu, Xian-Fu Lin, Qi Wu* Asymmetric synthesis of strongly fluorescent spirooxazino derivatives via multienzymatic telescopic reactions J. Mol. Catal. B: Enzym. 2017, http://dx.doi.org/10.1016/j.molcatb.2017.01.014 Yi-Ru Liang, Qi Wu* and Xian-Fu Lin*, Effect of Additives on the Selectivity and Reactivity of Enzymes, Chem. Rec, 2017, 17, 90–121 （invited review) Xueqin Li, Mingxin Yu, Zhichun Chen*, Xianfu Lin, Qi Wu*, A sensor for detection of carcinoembryonic antigen based on thepolyaniline-Au nanoparticles and gap-based interdigitated electrode, Sensors and Actuators B, 2017, 239, 874–882 Yu Zhang,† Bo Xia,† Yanyan Li, Yuanyuan Wang, Xianfu Lin, and Qi Wu*, Solvent-Free Lipase-Catalyzed Synthesis: Unique Properties of Enantiopure D- and L- Polyaspartates and Their Complexation,Biomacromolecules, 2016, 17, 362−370 Gui-Lin Cheng*，Hui Wang, Xian-Fu Lin, Qi Wu* Asymmetric Synthesis of Trifluoromethylated Amines and Their Derivatives Current Organic Synthesis, 2016, 13, 514–543 Xiao-Yang Chen, Jun-Liang Wang, Xian-Fu Lin, Qi Wu *, Lipase-initiated one-pot synthesis of spirooxazino derivatives: redesign of multicomponent reactions to expand substrates scope and application potential, Tetrahedron, 2016, 72, 3318-3323