个人简介

B.Sc. (Chemistry and Biochemistry) 1968, Victoria University of Wellington, New Zealand; M.Sc. (Chemistry/Biochemistry) 1970, Massey University, New Zealand; Ph.D. (Organic Chemistry) 1975, University of California, Berkeley

研究领域

Organic Chemistry/Chemical Biology/Biophysics

The Kent research group is devoted to inventing chemistries and applying them to reveal the molecular basis of protein function. To that end, we develop novel methods for the total synthesis of proteins that enable us to apply advanced physical methods in unprecedented ways to understand the chemical origins of protein structure and function. We then demonstrate that knowledge by the design and construction of protein molecules with novel properties.

近期论文

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Total chemical synthesis of biologically active fluorescent dye-labeled Ts1 toxin. Bobo Dang, Tomoya Kubota, Ana M. Correa, Francisco Bezanilla, Stephen B. H. Kent, Angewandte Chem Int Ed, 53, 8970-4 (2014). Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin. Michal Avital-Shmilovici, Jonathan Whittaker, Michael A. Weiss, Stephen B. H. Kent, J. Biol. Chem., 289, 23683-92 (2014). (Quasi-)racemic X-ray structures of glycosylated and non-glycosylated forms of the chemokine Ser-CCL1 prepared by total chemical synthesis. Ryo Okamoto, Kalyaneswar Mandal, Michael R. Sawaya, Yasuhiro Kajihara, Todd O. Yeates Stephen B. H. Kent, Angewandte Chem Int Ed, 53, 5194-8 (2014). Total chemical syntheses and biological activities of glycosylated and non-glycosylated forms of the chemokines CCL1 and Ser-CCL1. Ryo Okamoto, Kalyaneswar Mandal, Morris Ling, Andrew Luster, Yasuhiro Kajihara, Stephen B. H. Kent, Angewandte Chem Int Ed, 53, 5188-93 (2014). Total chemical synthesis of the enzyme Sortase AΔN59 with full catalytic activity. Fang-Kun Deng, Liang Zhang, Ya-Ting Wang, Olaf Schneewind, Stephen B. H. Kent, Angewandte Chem Int Ed, 53, 4662-6 (2014). Native chemical ligation at Asx-Cys, Glx-Cys: chemical synthesis and high resolution X-ray structure of ShK toxin by racemic crystallography. Bobo Dang, Tomoya Kubota, Kalyaneswar Mandal, Francisco Bezanilla, Stephen B.H. Kent, J. Am. Chem. Soc., 135, 11911-9 (2013). Bringing the science of proteins into the realm of organic chemistry: total chemical synthesis of SEP (synthetic erythropoiesis protein). Stephen B.H. Kent, Angew. Chem. Int. Ed., 52, 11988-11996 (2013). Rapid formal hydrolysis of peptide-αthioesters. Zachary P. Gates, Jules Stephan, Dong Jun Lee, Stephen B.H. Kent, Chem. Commun., 49, 786-788 (2013). Convergent chemical synthesis of ester insulin: determination of the high resolution X-ray structure by racemic protein crystallography. Michal Avital-Shmilovici, Kalyaneswar Mandal, Zachary P. Gates, Nelson Phillips, Michael A. Weiss, Stephen B.H. Kent, J. Am. Chem. Soc., 135, 3173–3185 (2013). Racemic protein crystallography. Todd O. Yeates, Stephen B.H. Kent, Ann. Review Biophysics, 41, 41–61 (2012).