个人简介

Born Baltimore, MD 1984 University of Maryland, College Park, B.S. in Biochemistry, 2005 University of California, Berkeley, Ph.D. in Chemistry, 2010 Postdoctoral Fellow, Harvard University, 2011-2014 Accolades 2013 American Chemical Society Nobel Laureate Signature Award 2011 Jane Coffin Childs Memorial Fund for Medical Research Fellowship 2011 NIH Individual Postdoctoral Fellowship (declined) 2010 Ash Stevens Outstanding Poster Award, Bioorganic Gordon Research Conference 2005 Departmental Honors, Chemistry and Biochemistry, University of Maryland, College Park 2005 Honors Citation, Environmental Studies, University of Maryland, College Park 2005 Alpha Chi Sigma Award, University of Maryland, College Park 2005 Spirit of Maryland Award Finalist, University of Maryland, College Park 2005 Phi Kappa Phi Honor Society, University of Maryland, College Park 2004 Howard Hughes Medical Institute Undergraduate Research Fellowship 2003 Joint Institute of Food Safety and Applied Nutrition Internship (FDA)

研究领域

Organic Chemistry/Chemical Biology/Biophysics

Research in the Dickinson lab lies at the interface of chemistry, biology, and engineering. We exploit our expertise in synthetic chemistry, protein engineering, molecular evolution, and cell biology to design and deploy new technologies for the interrogation of biological systems. Specifically, we seek to develop new methods to monitor and modulate chemical reactions in live mammalian cells, with a focus on decoding mammalian metabolic regulatory mechanisms. Synthetically derived small molecule fluorescent probes, engineered transcription-based protein sensors, and enzymes reprogrammed through continuous evolution currently constitute the three primary research efforts of the lab. All members of the lab will pursue their research projects in a highly interdisciplinary, collaborative, and collegial environment, forming a solid foundation for modern research in the field of Chemical Biology.

近期论文

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Dickinson, B.C.; Leconte, A.M.; Allen, B.; Esvelt, K.M.; Liu, D.R.L. "Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution." Proc. Natl. Acad. Sci. USA. 2013, 110, 9007-9012. Leconte, A.M.; Dickinson, B.C.; Yang, D.D.; Chen, I.A.; Allen, B.; Liu, D.R.L. "A population-based experimental model for protein evolution: Effects of mutation rate and selection stringency on evolutionary outcomes." Biochemistry. 2013, 52, 1490-1499. Dickinson, B.C.; Lin, V.S.; Chang. C.J. "Preparation and use of MitoPY1 imaging hydrogen peroxide in mitochondria of live cells." Nat. Prot. 2013, 8, 1249-1259. Dickinson, B.C.; Tang, Y.; Chang, Z.; Chang, C.J. "A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo." Chem. Biol. 2011, 18, 943-948. Dickinson, B.C.; Chang, C.J. "Chemistry and biology of reactive oxygen species in signaling or stress responses." Nat. Chem. Biol. 2011, 7, 504-511. Dickinson, B.C.; Peltier, J.; Stone, D.; Schaffer, D.V.; Chang, C.J. "Nox2 redox signaling maintains essential cell populations in the brain." Nat. Chem. Biol. 2011, 7, 106-112. Miller, E.W.; Dickinson, B.C.; Chang, C.J. "Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling." Proc. Natl. Acad. Sci. USA. 2010, 107, 15681-15686. Dickinson, B.C.; Huynh, C.; Chang, C.J. "A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells." J. Am. Chem. Soc. 2010, 132, 5906–5915. Dickinson, B.C.; Srikun, D.; Chang, C.J. "Mitochondrial-targeted fluorescent probes for reactive oxygen species." Curr. Opin. Chem. Biol. 2010, 14, 50–56. Dickinson, B.C.; Chang, C.J. "A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells." J. Am. Chem. Soc. 2008, 130, 9638–9639.