研究领域
化学生物学及生物有机化学,主要包括:1)生命有机磷化学;2)生物有机质谱;3)有机活性小分子与生物大分子的相互作用研究。
近期论文
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Jia-Ning Wang, Yan Liu*, Da-Cheng He, Yu-Fen Zhao. Studies on the Reaction between Peptides or Proteins with N-Phosphoryl Amino Acids in Aqueous Solution. Phosphorus, sulfur, silicon and related elements. 2008,183:764~772.
Xiao-xia Liu, Hua Fang, Yan Liu*, Yu-fen Zhao. Studies on the Contribution of Phosphoryl Group to the Non-Covalent Interaction between ATP and ?-Aminophosphonic Acids Derivatives by ESI-MS and Molecular Modeling. Phosphorus, sulfur, silicon and related elements. 2008, 183:791~796.
Yan Liu, Lu Jin, Jian-bo Hou, Peng-xiang Xu, Yu-fen Zhao. Variation in proton affinity of the guanidino group between free and blocked arginine. Amino acid, 2006, online,DOI:10.1007/s00726-006-0401-3.
Yan Liu, Peng-xiang Xu, Jian-bo Hou, Li-feng Yang, Jin-an Chen, Yu-fen Zhao. Chemical modification of insulin by N-phosphorylation. International Journal of Peptide Research and Therapeutics, 2005, 11: 167~175.
Liu Yan, Chen Xiao-Lan, He Juan, Hou Jian-Bo, Qu Ling-Bo, Zhao Yu-Fen. Characterization of Novel Nucleoside Analogues by Electrospray Ionization Mass Spectra. European Journal of Mass Spectrometry, 2004, 10: 699~703.
Gao X., Liu Y., Xu P. X., Cai Y. M., Zhao Y. F. ?-Amino acid behaves differently from ?- or ?-amino acids as treated by trimetaphosphate, Amino Acids, 2008, 34: 47~53.
Ning Zhou, Yan Liu, Gui-ji Zhou, Yu-fen Zhao. One pot conjugation of the polypeptides ditected by phosphorus oxychloride. Journal of Peptide Research, 2005, 65: 427~432.
Li-feng Yang, Lin Yu, Yan Liu, Yong Che, Li-ming Hu, Yu-fen Zhao. Direct observation of basic protein HEWL as an oxoanions receptor by electrospray ionization mass spectrometry. Letters in Peptide Science, 2003, 10: 89~92.
Changjin Zhu, Xiaoli Yang, Shuxia Cao, Yan Liu, Gu Yuan, Dan Liu, Yufen Zhao. Monitoring the synthetic reaction of a polyamide/peptide conjugate using electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry, 2003, 17: 825~831.
Ning Zhou, Li Ming Hu, Gui Ji Zhou, Yan Liu, Kui Lu, Yu Fen Zhao, ESI-MS studies on novel liquid homo-peptide libraries and their conjugate libraries directed by phosphorus oxychloride. Letters in peptide science, 2003, 10: 11~14.