王世珍 - 厦门大学 - 化学化工学院

研究领域

主要从事生物催化与转化、酶工程及手性化合物制备领域研究。研究内容包括海洋微生物新型酶开发，多酶耦联体系催化制备手性药物，工业微生物产品发酵技术，抗病毒、抗菌材料研发。每年计划招生1-2名研究生，欢迎生化工程、化工、生物和化学专业背景学生报考。

近期论文

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Shi-zhen Wang, Jing Wang, Xiao-fen Zhou, Ying-xia Guo, Bai-shan Fang*. The improvement of stability, activity and substrate promiscuity of glycerol dehydrogenase substituted by divalent metal ions. Biotechnology and Bioprocess Engineering, 2013,18:796-800. Shizhen Wang, Jianping Wu*, Gang Xu, Lirong Yang. Chemo-enzymatic asymmetric synthesis of S-citalopram by lipase-catalyzed cyclic resolution and stereoinversion of quaternary stereogenic center. Bioprocess and Biosystems Engineering. 2013, 36:1031-1037. Weiwei Wen, Shizhen Wang (Co-first author), Xiaofen Zhou, Baishan Fang*. Central carbon metabolism in marine bacteria examined with a simplified assay for dehydrogenases. Applied Biochemistry and Biotechnology, 2013, 170: 473-482. Yi-Qiang Peng, Shi-Zhen Wang, Ling Lan, Wei Chen, Bai-Shan Fang*.Resin adsorption application for product separation and catalyst recycling in coupled enzymatic catalysis to produce 1,3-propanediol and dihydroxyacetone for repeated batch. Engineering in Life Sciences, 2013, 13: 479-486. Shi-zhen Wang, Bai-shan Fang*. Microplate bioassay for determining substrate selectivity of Candida rugosa lipase. Journal of Chemical Education. 2012, 89: 409–411. Shizhen Wang, Jianping Wu, Gang Xu, Lirong Yang*. A kinetic and thermodynamic study of the lipase-catalyzed remote resolution of a chiral tertiary alcohol. Biochemical Engineering Journal. 2012, 65: 57-62. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*. Lipase-catalyzed remote kinetic resolution of citalopram intermediate by asymmetric alcoholysis and thermodynamic analysis. Bioprocess and Biosystems Engineering.2012, 35: 1043-1048. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*. Kinetic modeling of lipase catalyzed remote resolution of citalopram intermediate in solvent-free system. Biochemical Engineering Journal. 2009, 45: 113-119. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*. Separation of citalopram diol intermediate from its acetate using solvent extraction. Separation and Purification Technology. 2009, 68: 65-69. Shi-zhen Wang, Jian-ping Wu, Gang Xu, Li-rong Yang*. Resolution of citalopram intermediate by enzyme-catalyzed enantioselective transesterification in organic media. Chinese Journal of Organic Chemistry. 2008, 28: 1584-1589. 郭英霞, 王世珍, 王兆守, 陈荣, 方柏山. 金属离子对甘油脱氢酶活性中心的化学修饰. 厦大学报: 自然科学版. 2011, 50: 883-889. 温卫卫,周小芬,王世珍,方柏山, 基于氧化还原酶活性时变研究巴利阿里假单胞菌中心碳代谢，厦门大学学报(自然科学版),2013, 52:145-148.