个人简介
个人简介
2018.3-至今河南农业大学
2017.6-2017.12加州大学戴维斯副研究员
2014.6-2017.6加州大学戴维斯博士后
2011.6-2014.6明尼苏达大学博士后
2008.9-2011.6中科院成都生物所理学博士
2005.9-2008.6中科院成都有机化学所理学硕士
2001.9-2005.6西北农林科技大学理学学士
教授课程
本科生：酶工程。专利：
1吴中柳，刘艳杰，林晖；一株无色杆菌及其不对称催化还原碳碳双键的方法.专利号:ZL201210004039.1；申请日:2012.01.08；授权日:2013.06.05.
2吴中柳，林晖，刘艳，乔婧；一种苯乙烯环氧化酶基因及其用途，专利号:ZL201010120969.4；申请日：2010.03.10，授权日：2014.09.17.
3吴中柳，汤传根，张超，杨涛，刘章琴，林晖；一株粘红酵母及其制备(S)-羟基丙酰胺的方法，专利号ZL201010509822.4；申请日：2010.10.15；授权日2014.03.12.
4夏仕文,林晖,陈永正,方国兰,陈义文,徐红梅.一种制备（S）-5-（4-氟苯基）-5-羟基-戊酸甲酯的生物酶拆分法，专利号:ZL201210039374.5,授权日2014-05-14.
5.Fan,Z.andLin,H.EngineeringNeurosporacrassaforcellobionateproductiondirectlyfromcellulosewithoutanyenzymeaddition.USpatentserialno.62/422,513.
近期论文
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1Lin,H.,Kazlauskas,R.,Travisano,M.Developmentalevolutionfacilitatesrapidadaptation.ScientificResports7:15891(2017).
2Lin,H.,Travisano,M.,Kazlauskas,R.TheFungusTrichodermaRegulatesSubmergedConidiationUsingtheSteroidPregnenolone.ACSChemicalBiology1:2568-2575(2016).
3.Lin,H.,Liu,Y.&Wu,Z.-L.Highlydiastereo-andenantio-selectiveepoxidationofsecondaryallylicalcoholscatalyzedbystyrenemonooxygenase.ChemicalCommunications47,2610-2612(2011).
4Lin,H.,Kazlauskas,R.,Travisano,M.ExperimentalEvolutionofTrichodermacitrinovirideforFasterDeconstructionofCellulose.PlosOne11(1):e0147024(2016).
5Lin,H.,HildebrandA.,Takao,K.,Fan,Z.EngineeringNeurosporacrassaforcellobionateproductiondirectlyfromcellulosewithoutanyenzymeaddition.Enzymeandmicrobialtechnology.99:25-31(2017).
6Lin,H.,Tang,D.-F.,Ahmed,A.A.Q.,Liu,Y.&Wu,Z.-L.Mutationsattheputativeactivecavityofstyrenemonooxygenase:Enhancedactivityandreversedenantioselectivity.JournalofBiotechnology161,235-241(2012).
7Lin,H.,Liu,Y.&Wu,Z.-L.AsymmetricepoxidationofstyrenederivativesbystyrenemonooxygenasefromPseudomonasspLQ26:effectsofalpha-andbeta-substituents.Tetrahedron-Asymmetry22,134-137(2011).
8Lin,H.,Liu,J.-Y.,Wang,H.-B.,Ahmed,A.A.Q.&Wu,Z.-L.Biocatalysisasanalternativefortheproductionofchiralepoxides:Acomparativereview.JournalofMolecularCatalysisB-Enzymatic72,77-89(2011).
9Lin,H.,Qiao,J.,Liu,Y.&Wu,Z.-L.StyrenemonooxygenasefromPseudomonasspLQ26catalyzestheasymmetricepoxidationofbothconjugatedandunconjugatedalkenes.JournalofMolecularCatalysisB-Enzymatic67,236-241(2010).
10Lin,H.,Chen,Y.-Z.,Xu,X.-Y.,Xiaa,S.-W.&Wang,L.-X.Preparationofkeyintermediatesofadrenergicreceptoragonists:Highlyenantioselectiveproductionof(R)-alpha-halohydrinswithSaccharomycescerevisiaeCGMCC2.396.JournalofMolecularCatalysisB-Enzymatic57,1-5(2009).
11Nedrud,D.,Lin,H.,Lopez,G.,Padhi,S.,Kazlauskas,R.J.Uncoveringdivergentevolutionofα/β-hydrolases:asurprisingresiduesubstitutionneededtoconvertHeveabrasiliensishydroxynitrilelyaseintoanesterase.ChemicalScience5:4265-4277(2014).
12HildebrandA.*,SzewczykE.*,Lin,H.,Fan,Z.EngineeringNeurosporacrassaforImprovedCellobioseandCellobionateProduction.AppliedandEnvironmentalMicrobiology81:597–603(2015).
13Chen,Y.,Lin,H.,Xu,X.,Xia,S.&Wang,L.Preparationthekeyintermediateofangiotensin-convertingenzyme(ACE)inhibitors:Highenantioselectiveproductionofethyl(R)-2-hydroxy-4-phenylbutyratewithCandidaboidiniiCIOC21.AdvancedSynthesis&Catalysis350,426-430(2008).
14Liu,Y.-J.,Pei,X.-Q.,Lin,H.,Gai,P.,Liu,Y.-C.&Wu,Zh.-L.AsymmetricbioreductionofactivatedalkenesbyanovelisolateofAchromobacterspeciesproducingenoatereductase.AppliedMicrobiologyandBiotechnology95,635-645(2012).
15Tang,Ch.-G.,Lin,H.,Zhang,C.,Liu,Zh.-Q.,Yang,T.,Wu,Zh-L.HighlyenantioselectivebioreductionofN-methyl-3-oxo-3-(thiophen-2-yl)propanamidefortheproductionof(S)-duloxetine.BiotechnologyLetters33,1435-1440(2011).
16Qaed,A.A.,Lin,H.,Tang,D.-F.&Wu,Z.-L.Rationaldesignofstyrenemonooxygenasemutantswithalteredsubstratepreference.BiotechnologyLetters33,611-616(2011).
17Lin,H.,Chen,Y.-Z.,Xia,S.-W.&Wang,L.-X.CatalyticReductionofBenzoylAcetoneto(R)-or(S)-3-hydroxy-1-phenyl-1-butanonebyMicroorganismCells.ChineseJournalofSyntheticChemistry16,378-382,386(2008).
18Xia,S.W.,Lin,H.&Chen,Y.Z.Preparationof(R)-2-chloro-1-(m-chlorophenyl)ethanolbyLipozymeTLIM-catalyzedsecondresolution.ChineseChemicalLetters23,289-292(2012).
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