研究领域
有机新材料的合成研究：关于含硫富碳多炔键类化合物及其金属有机化合物的合成与应用研究；合成方法学研究：以α-氨基酸和α-羟基酸及其他天然原料为手性源的合成方法学，包括含氮杂环手性药物和天然产物的不对称合成方法研究；环加成反应研究：研究用1,3-偶极环加成方法合成光学活性的含杂原子环状化合物，并应用于天然产物合成；生物活性小分子合成研究：具有抗肿瘤或抗细菌活性的化合物合成及化合物结构与药效关系的研究。
近期论文
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Zhang, HK* Chan, WH, Lee, AWM, Wong, WY, “Regio- and stereoselective synthesis of isoxazolidine derivatives by asymmetric 1,3-dipolar cycloaddition reaction of chiral nitrones with 1-propene-1,3-sultone”, J. Heterocyl. Chem., 2008, 45, 957-962.
Lee, AWM, Chan, WH, Zhang, SJ, Zhang, HK*, “Non camphor based sultam chiral auxiliaries”, Curr. Org. Chem., 2007, 11, 213-228.
Zhang, HK* Chan, WH, Lee, AWM, Wong, WY, Xia, PF, “Synthesis of chiral sultams and their application as chiral auxiliaries in an asymmetric Diels-Alder reaction”, Tetrahedron: Asymmetry, 2005, 16, 761-771.
Meng, WH, Wu, TJ, Zhang, HK, Huang, PQ*, “Asymmetric syntheses of protected (2S,3S,4S)-3-hydroxy-4-methylproline and 4’-tert-butoxy amido-2’ -deoxythymidine”, Tetrahedron: Asymmetry, 2004, 15, 3899-3910.
Lee, AWM*, Chan, WH, Zhang, HK, “Sulfonate and sulfonamide activated olefins and acetylenes in [4+2] cycloaddition reactions”, Curr. Org. Chem., 2003, 6, 573-583.
Yang, RH, Chan, WH*, Lee, AWM, Xia, PF, Zhang, HK, Li, KA, “Ratiometric fluorescent sensor for Ag+ with high selectivity and sensitivity”, J. Am. Chem. Soc., 2003, 125, 2884-2885.
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