林东海 - 厦门大学 - 化学化工学院

研究领域

主要利用生物核磁共振技术开展结构生物学研究和代谢组学研究, 包括：(I) 测定蛋白质、多肽及其与配体复合物的溶液结构；(II) 研究蛋白质、多肽与配体的相互作用；(III) 测定蛋白质的动力学；(IV) 研究重大疾病的代谢特征、生物标志物和早期诊断方法；(V) 研究药物的药效、毒性和作用机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Characterization of the oligomerization and ligand-binding properties of recombinant rat lipocalin 11”, Y. Gu, Q. Liu, P. Chen, C. Guo, Y. Liu, Y. Zhao, Y.　Zhao, D. Lin*, BBA – Proteins and Proteomics 2012, in press. “Solution structural analysis of the single-domain parvulin TbPin1”，L. Sun, X. Wu, Y. Peng, J.Y. Goh, Y.-C. Liou, D. Lin*, PLoS ONE 2012，7：e43017-e43017. “Metabonomic analysis of the therapeutic effect of Zhibai Dihuang Pill in treatment of streptozotocin-induced diabetic nephropathy”, L. Zhao, H. Gao, Y. Zhao, D. Lin*, J. Ethnopharmacol 2012, 142(3): 647-656. “1H NMR-based metabonomics in the kidneys provides new insight into pathophysiological mechanisms: applications for treatment with Cordyceps sinensis“， F. Zhong, X. Liu, Q. Zhou, X. Hao, Y. Lu, S. Guo, W. Wang*, D. Lin*, Nan Chen, Nephrology Dialysis Transplantation 2012，27 (2): 556-565. “1H NMR-based metabolomic analysis of triptolide-Induced toxicity in liver-specific cytochrome P450 reductase knockout mice“，X. Liu, X. Xue, L. Gong, X. Qi, Y. Wu, G. Xing, Y. Luan, Y. Xiao, X. Wu, Y. Li, M. Chen，D. Lin*，J. Ren*, Metabolomics 2011，Dec 4, DOI 10.1007/s11306-011-0385-1. “1H NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotoci“, L. Zhao, H. Gao, F. Lian, X. Liu, Y. Zhao, D. Lin*, Am J Physiol Renal Physiol 2011，300 (4): F947-956. “Unique structural characteristics of the rabbit prion protein”, Y. Wen, J. Li, W. Yao, M. Xiong, J. Hong, Y. Peng, G. Xiao, D. Lin*, J. Biol. Chem. 2010, 285, 31682-31693. “Frog skins keep redox homeostasis by antioxidant peptides with rapid radical-scavenging ability”, C. Liu, J. Hong, H. Yang, J. Wu, D. Ma, D. Lin*, R. Lai*, Free Radic Biol. Med. 2010, 48, 1173-1181. “Solution Structure and Dynamics of the I214V mutant of the Rabbit Prion Protein”, Y. Wen, J. Li, M. Xiong, Y. Peng, W. Yao, J. Hong, D. Lin*, PLoS ONE 2010, 5, e13202. “Structural Transformation of the Tandem Ubiquitin-Interacting Motifs in Ataxin-3 and Their Cooperative Interactions with Ubiquitin Chains”, A. Song, C. Zhou, Y. Peng, X. Gao, Z. Zhou, Q. Fu, J. Hong, D. Lin*, H. Hu*, PLoS ONE 2010, 5, e13273. “Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao”, D. Ma, Y. Li, J. Dong, A. An, Y. Wang, C. Liu, X. Yang, H. Yang, X. Xu, D. Lin, R. Lai*, Allergy 2010, 66, 101-109. “Interaction with synphilin-1 promotes inclusion formation of ?-synuclein: mechanistic insights and pathological implication”, Y. Xie, C. Zhou, Z. Zhou, J. Hong, M. Che, Q. Fu, A. Song, D. Lin, H. Hu*, FASEB J. 2010, 24, 196-205. “The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity”, W. Yao, Y. Peng, D. Lin*, Biochem. Biophys. Research Commun. 2010, 396, 323-328. “Conformational and biochemical characterization of a rat epididymis-specific lipocalin 12 expressed in Escherichia coli”, Y. Peng, J. Liu, Q. Liu, Y. Yao, C. Guo, Y. Zhang, D. Lin*, BBA - Proteins and Proteomics 2010, 1804, 2102-2110. “A diketoreductase exhibits ubique renaturation profile form thermal-induced protein unfolding”, M. Lu, X. Cao, X. Yang, H. Zheng, N Liu, Y. Jang, D. Lin*, Y. Chen*, Amino Acids 2010, 39, 609-613. “Soluble expression and characterization of a mouse epididymis-specific protein lipocalin6”, C. Guo, Y. Lian, Q. Liu, J. Liu, y. Zhang, D. Lin*, Protein Express Purify 2010, 69, 64-67. “Systemic metabolic changes of traumatic critically II patients revealed by an NMR-based metabonomic approach”, H. Mao, H. Wang, B.Wang,X.Liu, H.Gao, M.Xu, H.Zhao, X.Deng*, D.Lin*, J. Proteomics Res. 2009, 8, 5423-5430. “The first amphibian neurotoxin reveal the ecological adaptation of the tree frog, Hyla annectans”，You D, Hong J, Rong M, Liang S, Ma Y, Yang H, Wu J, Lin D*, Lai R*, J. Biol. Chem. 2009, 284, 22079-22086. (highlight article in America Society of Biochemistry and Molecular Biology) “Structural basis for Ubiquitin recognition by a novel domain from human phospholipase A2 activating protein”, Q. Fu, C. Zhou, H. Gao, Y. Jiang, Z. Zhou, J. Hong, W. Yao, A. Song, D. Lin*, H. Hu*, J. Biol. Chem. 2009, 284 , 1043-19052. “Antioxidant peptideomics reveals novle skin antioxidant system”, H. Yang, X. Wang, X. Liu, J. Wu, C. Liu, W. Gong, Z. Zhao, J. Hong. D. Lin, R. Lai*, Mol. Cell. Proteomics 2009, 8, 571-583. “Recombinant expression and characterization of an epididymis-specific antimicrobial peptide BIN1b/SPAG11E”, C. Guo, H. Diao, Y. Lian, H. Gao, Y. Zhang, D. Lin*, J. Biotech. 2009, 139, 33-37. “Application of 1H NMR-based metabonomics in the study of metabolic profiling of human hepatocellular carcinoma and liver cirrhosis”, H. Gao, Q. Lu, X. Liu, H. Cong, H. Wang*, D. Lin*, Cancer Science 2009, 100, 782-785. “Molecular basis of the interaction of Saccharomyce scerevisiae Eaf3 chromo domain with methylated H3K36”， B. Sun, J. Hong, P. Zhang, X. Dong, X. Shen, D. Lin*, J. Ding*, J. Biol. Chem. 2008, 28，36504-36512. “Snake Cathelicidin from Bungarus fasciatus is a potent peptide antibiotics”, Y. Wang, J. Hong, X. Liu, H. Yang, D. Lin*, R. Lai*, PLoS ONE 2008，3，e3217. (Research highlights in Nature China 2008-11)