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个人简介

学士(厦门大学,1998) 硕士(厦门大学,2001) 博士(美国佛罗里达大学,2006) 博士后(美国加州大学伯克利分校, 2006-2007)

研究领域

单细胞时空组学测序、液体活检、微流控芯片、功能核酸、智能仪器与器件

近期论文

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Cao,  J; Zheng,  Z; Sun, D; Chen, X; Cheng, R; Lv, T; An, Y; Zheng, J*; Song, J*; Wu, L*; Yang, C*; Decoder-seq enhances mRNA capture efficiency in spatial RNA sequencing. Nat. Biotechnol. 2024, DOI: https://doi.org/10.1038/s41587-023-02086-y Lin, X; Chen, Y; Lin, L; Yin, K; Cheng, R; Lin, X; Wang, X; Guo, Y; Wu, Z; Zhang, Y; Li, J*; Yang, C*; Song, J*; mitoSplitter: A mitochondrial variants-based method for efficient demultiplexing of pooled single-cell RNA-seq. Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2307722120 Yu, X, Ruan, W; Lin, F; Qian, W; Zou, Y; Liu, Y; Su, R; Niu, Q; Ruan, Q; Lin, W; Zhi Zhu, Zhang, H* ; Yang, C*, Digital microfluidics-based digital counting of single-cell copy number variation (dd-scCNV Seq), Proc. Natl. Acad. Sci. U. S. A., 2023, 120, e2221934120. Lei, Y#, Fei, X#, Ding, Y; Zhang, J; Zhang, G; Dong, L; Song, J; Zhuo, Y; Xue, W; Zhang, P*; Yang, C*; Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding. Sci Adv. 2023, 9, eadi1556. Zhang, G; Wang, Y; Zhou, W ; Lei, Y; Lu, J; Yin, W*; Zhu, Z*; Yang, C*; Zhang, P*; A Magnetically Driven Tandem Chip Enables Rapid Isolation and Multiplexed Profiling of Extracellular Vesicles. Angew. Chem. Int. Ed., 2023, 62, e202315113. Lin,S; Yin, K; Zhang, Y; Lin, F; Chen, X; Zeng, X; Guo, X; Zhang, H; Song, J*; Yang, C*, Well-TEMP-seq as a microwell-based strategy for massively parallel profiling of single-cell temporal RNA dynamics. Nat. Commun. 2023, 14, 1272 Chen, D; Guo, J; Li, A; Sun, C; Lin, H; Lin, H; Yang, C*; Wang, W*; Gao, J*. Metabolic Fluorine Labeling and Hotspot Imaging of Dynamic Gut Microbiota in Mice. Sci. Adv., 2023, 9, eabg6808. Chen, H; Su, M; Lei, Y ; Ye, Z; Chen, Z ; Ma, P ; Yuan, R* ; Zhuo, Y*; Yang, C*; Liang, W*; Insights of Life Molecules' Dynamic Distribution in Live Cells via Sequence-Structure Bispecific Fluorescent RNA, J. Am. Chem. Soc, 2023, 145, 12812-12822. Niu, Q; Gao, J; Zhao, K; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*, Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A., 2022, 119, e2213236119. Guo, X; Lin, F; Yi, C; Song, J; Sun, D; Lin, L; Zhong, Z; Wu, Z; Wang, X; Zhang, Y; Li, J; Zhang, H*; Liu, F*; Yang, C*; Song, J*; Deep transfer learning enables lesion tracing of circulating tumor cells. Nat. Commun. 2022, 13, 7687. Lin, L; Zhang, Y; Qian, W; Liu, Y; Zhang, Y; Lin, F; Liu, C; Lu, G; Sun, D; Guo, X; Song, Y; Song, J*; Yang, C*; Li J*, LINEAGE: Label-free identification of endogenous informative single-cell mitochondrial RNA mutation for lineage analysis, Proc. Natl. Acad. Sci. U. S. A, 2022, 119, e2119767119. Niu, Q#; Gao, J#; Zhao, K#; Chen, X; Lin, X; Huang, C; An, Y; Xiao, X; Wu, Q; Cui, L*; Zhang, P*; Wu, L*; Yang, C*, Fluid Nanoporous Microinterface Enables Multiscale-Enhanced Affinity Interaction for Tumor-Derived Extracellular Vesicle Detection. Proc. Natl. Acad. Sci. U. S. A,, 2022, 119, e2213236119. Wu, L; Wang, Y; Xu,X; Liu, Y; Lin, B; Zhang, M, Zhang, J; Wan, S; Yang, C*; Tan, W*; Aptamer-Based Detection of Circulating Targets for Precision Medicine, Chem. Rev. 2021, 121, 12035–12105 Zhu, L; Xu, Y; Wei, X; Lin, H; Huang, M; Lin, B; Song, Y*; Yang, C*; Coupling Aptamer-based Protein Tagging with Metabolic Glycan Labeling for In Situ Visualization and Biological Function Study of Exosomal Protein-Specific Glycosylation. Angew. Chem. Int. Ed., 2021, 60, 18111-18115. Sun, M; Liu, S; Song, T; Chen, F; Zhang, J; Huang, J; Wan, S; Lu, Y; Chen, H*; Tan, W*; Song, Y*; Yang, C*; Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape, J. Am. Chem. Soc., 2021, 143, 21541-21548. Sun, M; Liu, S; Wei, X; Wan, S; Huang, M; Song, T; Lu, Y; Weng, X; Lin, Z; Chen, H*; Song, Y*; Yang, C*; Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angew. Chem. Int. Ed. 2021, 60, 10354-10360. Lin, B; Tian, T; Lu, Y; Liu, D; Huang, M; Zhu, L; Zhu, Z; Song, Y*; Yang, C*; Tracing Tumor-derived Exosomal PD-L1 by Dual-aptamer Activated Proximity-induced Droplet Digital PCR, Angew. Chem. Int. Ed., 2021, 60, 7582-7586. Zhang, M; Zou, Y; Xu, X; Zhang, X; Gao, M; Song, J; Huang, P; Chen, Q; Zhu, Z; Lin, W; Zare, R; Yang, C*; Highly Parallel and Efficient Single Cell mRNA Sequencing with Paired Picoliter Chambers. Nat. Commun., 2020, 11, 2118. Lin, L; Du, Y; Song, J; Wang, W*; Yang, C*. Imaging Commensal Microbiota and Pathogenic Bacteria in the Gut, Acc. Chem. Res., 2021, 54, 2076–2087 Zhang, J; Lin, B; Wu, L; Huang, M; Li, X; Zhang, H; Song, J; Wang, W; Zhao, G*; Song, Y*; Yang, C*; DNA Nanolithography Enables Highly Ordered Recognition Interface in Microfluidic Chip for Efficient Capture and Release of Circulating Tumor Cells, Angew. Chem. Int. Ed., 2020, 59,14115-14119. Lin, L; Song, J; Du, Y; Wu, Q; Gao, J; Song, Y; Yang, C*; Wang, W.*; Quantification of Bacterial Metabolic Activities in the Gut by D-Amino Acid-based in vivo Labeling. Angew. Chem. Int. Ed., 2020, 59, 12021-12024. Wu, L; Ding, H; Qu, X; Shi, X; Yang, J; Huang, M; Zhang, J; Zhang, H; Song, J; Zhu, L; Song, Y*; Ma, Y*; Yang, C*; Fluidic Multivalent Membrane Nanointerface Enables Synergetic Enrichment of Circulating Tumor Cells with High Efficiency and Viability. J. Am. Chem. Soc, 2020, 142, 4800-4806 Ruan, Q; Ruan, W; Lin, X; Wang, Y; Zou, F; Zhou, L; Zhu, Z; Yang, C*; Digital-WGS: Automated, Highly Efficient Whole-genome Sequencing of Single Cells by Digital Microfluidics, Sci. Adv., 2020, 6: eabd6454. Wang, W; Yang, Q; Du, Y, Zhou, X, Du, X, Wu, Q, Lin, L, Song, Y, Li, F, Yang, C*, Tan, W*. Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., 2020,59, 2628-2633 Lin, L; Wu, Q; Song, J; Du, Y; Gao, J; Song, Y; Wang, W*; Yang, C*, Revealing the in vivo growth and division patterns of mouse gut bacteria, Sci. Adv., 2020, 6, eabb2531. Huang, M; Yang, J; Wang, T; Song, J; Xia, J; Wu, L; Wang, W; Wu, Q; Zhu, Z; Song, Y*; Yang, C*; Homogeneous, Low-volume, Efficient and Sensitive Quantitation of Circulating Exosomal PD-L1 for Cancer Diagnosis and Immunotherapy Response Prediction. Angew. Chem. Int. Ed., 2020, 59, 4800-4805. Wang, W*; Zhang, N; Du, Y; Gao, J; Li, M; Lin, L; Czajkowsky, D; Li, X*; Yang, C*; Shao, Z. Three-dimensional Quantitative Imaging of Native Microbiota Distribution in the Gut. Angew. Chem. Int. Ed., 2021, 60, 3055-3061. Wang, W; Lin, L; Du, Y; Song, Y; Peng, X; Chen, X*; Yang, C*. Assessing the Viability of Transplanted Gut Microbiota by Sequential Tagging with D-Amino acid-based Metabolic Probes. Nature Commun., 2019, 10, 1317 Song, Y; Shi, Y; Huang, M; Wang, W; Wang, Y; Cheng, J; Lei, Z; Zhu, Z; Yang, C*; Bioinspired Engineering of Multivalent Aptamer-Functionalized Nanointerface to Enhance Capture and Release of Circulating Tumor Cells. Angew. Chem. Int. Ed., 2019, 58, 2236-2240

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