孟震 - 聊城大学

个人简介

学习经历: 2004年9月至2009年7月于青岛大学医学院攻读口腔医学学士学位； 2010年9月至2015年7月于北京大学口腔医学院攻读口腔颌面外科学博士学位（硕博连读）。工作经历： 2015年7月于聊城市人民医院口腔科工作，先后任住院医师和主治医师，从事口腔颌面外科门诊常见病和多发病的诊疗； 2017年6月至今任聊城市人民医院精准生物医学重点实验室常务副主任。　　【科研成果】　　承担或参与的科研项目　　（1）肿瘤相关成纤维细胞调控舌癌细胞中PTEN活性促进舌癌转移的研究，国家自然科学基金青年科学基金项目，2017.01-2019.12 ，承担　　（2）PTEN膜转位在肿瘤相关成纤维细胞调控舌癌放疗抵抗中的作用，省自然科学基金青年科学基金项目，2016.11-2019.06，承担　　（3）ZNF750调控E2F2抑制口腔鳞癌恶性进展的分子机制及靶点确认，国家自然科学基金面上项目，2018.01-2021.12，参与（第2位）　　（4）circBCBM1靶向结合miR-145调控乳腺癌脑转移的机制研究，国家自然科学基金青年科学基金项目，2018.01-2018.12，参与（第4位）　　（5）雌激素通过cadherin-11加重颞下颌关节验证机制的研究，国家自然科学基金青年科学基金项目，2014.01-2016.12，参与（第5位）　　（6）抑癌基因PTEN在组蛋白脱乙酰酶抑制剂抗肿瘤作用中的作用，国家自然科学基金面上项目，2015.01-2018.12，参与（第5位）　　（7）CTCs肿瘤指纹基因液态活检在乳腺癌脑转移早期预警中的应用基础研究，山东省自然科学基金博士基金项目，2016.11-2018.11，参与（第5位）　　（8）肝激酶LKB1在头颈部鳞癌组织中的表达及其与鳞癌生物学特征相关性的研究，山东省医药卫生科技发展计划，2017.12-2020.12 ，参与（第4位）　　

近期论文

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（1） Meng Zhen*, Jia Ling-fei and Gan Yehua: PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition. Oncogene 35: 2333-2344, 2016.　　（2）Meng Zhen* and Gan Yehua: Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization. Biochemical and biophysical research communications 460: 198-204, 2015.　　（3）Kou Xiaoxing*, Hao Ting*, Meng Zhen*, Zhou YH and Gan YH: Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion. Carcinogenesis 34: 58-67, 2013.　　（4）Yuan Daoying, Meng Zhen, Xu Kai, Li Qiaofeng, Chen Cheng, Li Keyi and Zhang Bin. Betulinic acid increases radiosensitization of oral squamous cell carcinoma through inducing Sp1 sumoylation and PTEN expression. Oncol Rep 2017; 38: 2360-2368.　　（5）Pan Li, Yang Hongli, Xu Cong, Chen Shuangfeng, Meng Zhen, Li Keyi and Chen Haiying. ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. Biomed Pharmacother 2018; 105: 566-572.　　（6）Pan Li, Yang Hongli, Tang Wenqiang, Xu Cong, Chen Shuangfen, Meng Zhen, Li Keyi and Chen Haiying. Pathway-focused PCR array profiling of CAL-27 cell with over-expressed ZNF750. Oncotarget 2018; 9: 566-575.　　（7）Liu Jianlin, Zhang Anqi, Jiang Licheng, Li Keyi, Liu Fengzhen, Yuan Daoying, Xu Kai, Fan Qingchun, Liu Xianbin, Zou Bo, Meng Zhen, Feng Yuanyuan and Zhang Bin. The efficacy of polidocanol sclerotherapy in mucocele of the minor salivary gland. J Oral Pathol Med 2018; 47: 895-899.　　（8） Xue Xintong, Kou Xiaoxin, Li Chenshuang, Bi Ruiyun, Meng Zhen, Wang Xuedong, Zhou Yanheng and Gan Yehua. Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-kappaB pathway in ovariectomized rats. Sci Rep 2017; 7: 15334.　　（9） Bi Ruiyun, Meng Zhen, Zhang Peng, Wang Xuedong, Ding Yun and Gan Yehua. Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ. PLoS One 2017; 12: e0178589.　　（10） Zhang Bin, Li Keyi, Jiang Licheng, Meng Zhen, Wang Xiumei, Cui Fuzhai, Zhu Yingnan and Wu Yaping. Rib Composite Flap With Intercostal Nerve and Internal Thoracic Vessels for Mandibular Reconstruction. J Craniofac Surg 2016; 27: 1815-1818.　　（11） Kou Xiaoxing, Li Chenshuang, He Danqing, Wang Xuedong, Hao Ting, Meng Zhen, Zhou Yanheng and Gan Yehua. Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats. J Immunol 2015; 194: 2810-2818.　　（12） Jia Lingfei, Huang Yiping, Zheng Yunfei, Lyu Mingyue, Zhang Chunan, Meng Zhen, Gan Yehua and Yu guanyan. miR-375 inhibits cell growth and correlates with clinical outcomes in tongue squamous cell carcinoma. Oncol Rep 2015; 33: 2061-2071.　　（13） Tang Xiufeng, Bi Ruiyun, Meng Zhen and Gan Yehua. Stereotaxis of mandibular nerve initial point of trigeminal ganglion in rats. Chin J Dent Res 2014; 17: 99-104.　　（14） Kou Xiaoxing, Wang Xuedong, Li Chenshuang, Bi Ruiyun, Meng Zhen, Li Bei, Zhou Yanheng and Gan Yehua. Estradiol-potentiated cadherin-11 in synovial membrane involves in temporomandibular joint inflammation in rats. J Steroid Biochem Mol Biol 2014; 143: 444-450.　　（15）Jia Lingfei, Wei SuBi, Mitchelson Keith, Gao Yan, Zheng Yunfei, Meng Zhen, Gan Yehua and Yu Guangyan. miR-34a inhibits migration and invasion of tongue squamous cell carcinoma via targeting MMP9 and MMP14. PLoS One 2014; 9: e108435.　　（16）Jia Lingfei, Huang Yiping, Zheng Yunfei, Lyu Mingyue, Wei SuBi, Meng Zhen and Gan Yehua. miR-29b suppresses proliferation, migration, and invasion of tongue squamous cell carcinoma through PTEN-AKT signaling pathway by targeting Sp1. Oral Oncol 2014; 50: 1062-1071.　　（17）Wang Xuedong, Kou Xiaoxing, Meng Zhen, Bi Ruiyun, Liu Yan, Zhang JieNi, Zhou Yanheng and Gan Yehua. Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis. J Dent Res 2013; 92: 918-924.　　（18） Bi Ruiyun, Kou Xiaoxing, Meng Zhen, Wang Xuedong, Ding Yun and Gan Yehua. Involvement of trigeminal ganglionic Nav 1.7 in hyperalgesia of inflamed temporomandibular joint is dependent on ERK1/2 phosphorylation of glial cells in rats. Eur J Pain 2013; 17: 983-994.　　（19）Wang Xuedong, Kou Xiaoxing, He Danqing, Zeng Minmin, Meng Zhen, Bi Ruiyun, Liu Yan, Zhang Jieji, Gan Yehua and Zhou Yanheng. Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate. PLoS One 2012; 7: e45036.　　（20）毕瑞芸，寇晓星，孟震，甘业华: 钠离子通道1.8参与调控大鼠颞下颌关节炎性痛及其性别差异. 科学技术与工程 12: 5980-5984, 2012.　　