个人简介

Zhuang received her B.S. degree in Physics from the University of Science and Technology of China, Ph.D. Degree in Physics from the University of California at Berkeley, and postdoctoral training in biophysics at Stanford University. In 2001, she became an assistant professor at Harvard University, where she was promoted to associate professor in 2005 and full professor in 2006. She joined the Howard Hughes Medical Institute as an investigator in 2005. Zhuang is a member of the National Academy of Sciences, a fellow of American Association of the Advancement of Science, and a fellow of the American Physical Society. She serves on the editorial boards of Cell, eLife, Annual Review of Biophysics, Chemical Physics Letters, and Optical Nanoscopy.

研究领域

Biophysics/Physical/Chemical Physics

Xiaowei Zhuang works in the areas of single-molecule biology and bioimaging, developing imaging techniques to study biological systems quantitatively. The understanding of living organisms has greatly benefited from imaging tools. In particular, understanding the inner workings of a cell requires imaging techniques with molecular-scale resolution such that molecular interactions and processes inside the cell can be directly visualized. Members of the Zhuang lab apply their diverse expertise in chemistry, physics, biology and engineering to develop imaging methods with single-molecule sensitivity, nanometer-scale resolution, and dynamic imaging capability to meet these challenges. They further apply these tools to study a variety of biological problems, such as how proteins and nucleic acids interact, how viruses infect cells, and how neurons compute.

近期论文

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G. Zhong, J. He, R. Zhou, D. Lorenzo, H.P. Babcock, V. Bennett, X. Zhuang, "Developmental mechanism of the periodic membrane skeleton in axons" eLife C.Y. Chan, H. Zhao, R.J. Pugh, A.M. Pedley, J. French, S.A. Jones, X. Zhuang, H. Jinnah, T.J. Huang, S.J. Benkovic, "Purinosome formation as a function of the cell cycle" PNAS in press T. Shemesh, R.W. Klemm, F.B. Romano, S. Wang, J.C. Vaughan, X. Zhuang M.M. Kozlov, T.A. Rapoport, "A model for the generation and interconversion of ER morphologies" PNAS in press D.N. Lorenzo, A. Badea, J. Davis, J. Hostettler, J. He, G. Zhong, X. Zhuang, V. Bennett, "A PIK3C3-Ankryin-B-Dynactin pathway promotes axonal growth and multiorganelle transport" J. Cell Biol 207, 735-752 (2014) W.L. Hwang, S. Deindl, B.T. Harada, X. Zhuang, "Histone H4 tail mediates allosteric regulation of nucleosome remodelling by linker DNA" Nature 512, 213-217 (2014) A. Blunk, Y. Akbergenova, R. Cho, J. Lee, U. Walldorf, K. Xu, G. Zhong, X. Zhuang, J. Littleton, "Postsynaptic actin regulates active zone spacing and glutamate receptor apposition at the Drosophila neuromuscular junction" Mol. Cell. Neurosci. 61, 241-254 (2014) S. Wang, J. Moffitt, G. Dempsey, X. Xie, X. Zhuang, "Characterization and development of photoactivatable fluorescent proteins for single molecule based superresolution imaging" Proc. Natl. Acad. Sci. USA 111, 8452-8457 (2014) J. Chung, S. Shim, R. Everley, S. Gygi, X. Zhuang, D. Clapham, "Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility", Cell 157, 808-822 (2014) S. Jia, J. Vaughan, X. Zhuang, "Isotropic three-dimensional super-resolution imaging with a self-bending point spread function", Nature Photonics 8, 302-306 (2014) A. Avalos, A. Bilate, M. Witte, A. Tai, J. He, M. Frushicheva, P. Thill, F. Meyer-Wentrup, C. Theile, A. Chakraborty, X. Zhuang, H. Ploegh, "Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells", JEM 211, 365-379 (2014) K. Xu, G. Zhong, X. Zhuang, "Actin, spectrin and associated proteins form a periodic cytoskeleton structure in axons", Science 339, 452-456 (2013) Y. Doksani, J. Wu, T. de Lange, X. Zhuang, "Super-resolution fluorescence imaging reveals TRF2-dependent t-loop formation", Cell 155, 345-356 (2013) H. Babcock, J. Moffitt, Y. Cao, X. Zhuang, "Fast compressed sensing analysis for super-resolution imaging using L1-homotopy", Optics Express 21, 28583-28596 (2013) S. Deindl, W.L. Hwang, S.K. Hota, T.R. Blosser, P. Prasad, B. Bartholomew, X. Zhuang, "ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps", Cell 152, 442-452 (2013) J. He, E. Sun, M.B. Bujny, D. Kim, M.W. Davidson, X. Zhuang, "Dual function of CD81 in influenza uncoating and budding", PLOS Pathogens, (2013) S. Hota, S. Bhardwaj, S. Deindl, Y. Lin, X. Zhuang, B. Bartholomew, "Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains", Nature Structural and Molecular Biology 20, 222-229 (2013) J.C. Vaughan, G.T. Dempsey, E. Sun, X. Zhuang, "Phospine Quenching of Cyanin Dyes as a Versatile Tool for Fluorescence Microscopy", JACS 135, 1197-1200 (2013) E. Sun, J, He, X. Zhuang, "Live cell imaging of viral entry", Current Opinion in Virology 3, 34-43 (2013) A. Alivisatos, A. Andrews, E. Boyden, M. Chun, G. Church, K. Deisseroth, J. Donoghue, S. Fraser, J. Lippincott-Schwartz, L. Looger, S. Masmanidis, P. McEuen, A. Nurmikko, H. Park, D. Peterka, C. Reid, M. Roukes, A. Scherer, M. Schnitzer, T. Sejnowski, K. Shepard, D. Tsao, G. Turrigiano, P. Weiss, C. Xu, R. Yuste, X. Zhuang, "Nanotools for neuroscience and brain activity mapping", ACS Nano 7, 1850-1866 (2013) E. Sun, J. He, X. Zhuang, "Dissecting the role of COPI complexes in influenza virus infection", Journal of Virology 87, 2673-2685 (2013)