Xie, X. Sunney - Harvard University - Department of Chemistry and Chemical Biology

个人简介

Xiaoliang Sunney Xie received a B.S. from Peking University in 1984, and his Ph.D. from the University of California at San Diego in 1990, followed by a short postdoctoral experience at the University of Chicago. In 1992, Xie joined Pacific Northwest National Laboratory, where he later became a Chief Scientist. In 1999, he was appointed Professor of Chemistry at Harvard University. He is now the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard, and the Cheung Kong Visiting Professor at Peking University, Biodynamics Optical Imaging Center (BIOPIC). Xie has made major contributions to the emergence of the field of single-molecule biophysical chemistry and its application to biology. His team also pioneered the development of coherent Raman scattering microscopy and single cell whole genome sequencing. His honors include the Harrison Howe Award, Biophysical Society Founders Award, E.O. Lawrence Award in Chemistry, Leibinger Innovation Prize, the NIH Director's Pioneer Award, the Sackler Prize for Physical Sciences. Xie is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences.

研究领域

Biophysics/Physical/Chemical Physics

近期论文

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Chen, Huiyi; Shiroguchi, Katsuyuki; Ge, Hao; Xie, X. Sunney "Genome-wide study of mRNA degradation and transcript elongation in Escherichia coli," Mol Syst Biol 11:781 DOI:10.15252/msb.20145794 (2015) Ge, Hao; Qian, Hong; and Xie, X. Sunney "Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching," Phys Rev Lett 114(7), 078101, DOI:10.1103/PhysRevLett.114.078101 (2015) Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie, X. Sunney. "Mechanism of Transcriptional Bursting in Bacteria," Cell 158, 314-326 DOI:http://dx.doi.org/10.1016/j.cell.2014.05.038 (2014) Fu, Dan; Xie, X. Sunney. "Reliable Cell Segmentation Based on Spectral Phasor Analysis of Hyperspectral Stimulated Raman Scattering Imaging Data," Anal. Chem. 9, 4115-4119 DOI:10.1021/ac500014b (2014) Fu, Dan; Yu, Yong; Folick, Andrew; Currie, Erin; Farese, Robert V., Jr.; Tsai, Tsung-Huang; Xie, X. Sunney; Wang, Meng C. "In Vivo Metabolic Fingerprinting of Neutral Lipids with Hyperspectral Stimulated Raman Scattering Microscopy," J. Am. Chem. Soc. 136, 8820-8828 DOI:10.1021/ja504199s (2014) Fu, Dan; Zhou, Jing; Zhu, Wenjing Suzanne; Manley, Paul W.; Wang, Y. Karen; Hood, Tami; Wylie, Andrew; Xie, X. Sunney. "Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering," Nat Chem 6, 614-622 DOI:10.1038/nchem.1961 (2014) Freudiger, Christian W.; Yang, Wenlong; Holtom, Gary R.; Peyghambarian, Nasser; Xie, X. Sunney; Kieu, Khanh Q. "Stimulated Raman scattering microscopy with a robust fibre laser source," Nature Photonics 8, 153-159 DOI:10.1038/nphoton.2013.360 (2014) Zhao, Ziqing W.; Roy, Rahul; Gebhardt, J. Christof M.; Suter, David M.; Chapman, Alec R.; Xie, X. Sunney. "Spatial organization of RNA polymerase II inside a mammalian cell nucleus revealed by reflected light-sheet superresolution microscopy," PNAS 111, 681-686 DOI:10.1073/pnas.1318496111 (2014) Xie, X. Sunney. "Enzyme Kinetics, Past and Present," Science 342, 1457-1459 DOI:10.1126/science.1248859 (2013) Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, X. Sunney; Qiao, Jie. "Genome Analyses of Single Human Oocytes," Cell 155, 1492-1506 DOI:10.1016/j.cell.2013.11.040 (2013) See Cell PaperFlick movie Tan, Longzhi; Zong, Chenghang; Xie, X. Sunney. "Rare event of histone demethylation can initiate singular gene expression of olfactory receptors," PNAS 110,21148-21152 DOI: 10.1073/pnas.1321511111 (2013) Ni, Xiaohui; Zhuo, Minglei; Su, Zhe; Duan, Jianchun; Gao, Yan; Wang, Zhijie; Zong, Chenghang; Bai, Hua; Chapman, Alec R.; Zhao, Jun; Xu, Liya; An, Tongtong; Ma, Qi; Wang, Yuyan; Wu, Meina; Sun, Yu; Wang, Shuhang; Li, Zhenxiang; Yang, Xiaodan; Yong, Jun; Su, Xiao-Dong; Lu, Youyong; Bai, Fan; Xie, X. Sunney; Wang, Jie. "Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients," PNAS 110, 21083-21088 DOI: 10.1073/pnas.1320659110 (2013) Ji, Minbiao; Orringer, Daniel A.; Freudiger, Christian W.; Ramkissoon, Shakti; Liu, Xiaohui; Lau, Darryl; Golby, Alexandra J.; Norton, Isaiah; Hayashi, Marika; Agar, Nathalie Y. R.; Young, Geoffrey S.; Spino, Cathie; Santagata, Sandro; Camelo-Piragua, Sandra; Ligon, Keith L.; Sagher, Oren; Xie, X. Sunney. "Rapid, Label-Free Detection of Brain Tumors with Stimulated Raman Scattering Microscopy," Science Translational Medicine 5, 201ra119 DOI: 10.1126/scitranslmed.3005954 (2013) Xu, Xinliang; Ge, Hao; Gu, Chan; Gao, Yi Qin; Wang, Siyuan S.; Thio, Beng Joo Reginald; Hynes, James T.; Xie, X. Sunney; Cao, Jianshu. "Modeling Spatial Correlation of DNA Deformation: DNA Allostery in Protein Binding," J. Phys. Chem. B 117, 13378-13387 DOI: 10.1021/jp4047243 (2013) Gebhardt, J. Christof M.; Suter, David M.; Roy, Rahul; Zhao, Ziqing W.; Chapman, Alec R.; Basu, Srinjan; Maniatis, Tom; Xie, X. Sunney. "Single-Molecule Imaging of Transcription Factor Binding to DNA in Live Mammalian Cells," Nat Methods 10, 421-426 DOI:10.1038/NMETH.2411 (2013) Fu, Dan; Holtom, Gary; Freudiger, Christian; Zhang, Xu; Xie, X. Sunney. "Hyperspectral Imaging with Stimulated Raman Scattering by Chirped Femtosecond Lasers," J Phys Chem B 117, 4634-4640 DOI:10.1021/jp308938t (2013) Kim, Sangjin; Broströmer, Erik; Xing, Dong; Jin, Jianshi; Chong, Shasha; Ge, Hao; Wang, Siyuan; Gu, Chan; Yang, Lijiang; Gao, Yi Qin; Su, Xiao-dong; Sun, Yujie; Xie, X. Sunney. "Probing Allostery Through DNA," Science 339, 816-819 (2013). Kong, Lingjie; Ji, Minbiao; Holtom, Gary R.; Fu, Dan; Freudiger, Christian W.; Xie, X. Sunney. "Multicolor Stimulated Raman Scattering Microscopy with a Rapidly Tunable Optical Parametric Oscillator," Optics Letters 38, 145-147 (2013).