Szostak, Jack W. - Harvard University - Department of Chemistry and Chemical Biology

研究领域

Biophysics/Chemical Biology/Origins of Life The first protocell membranes may have assembled from fatty acids and related single-chain lipids available in the prebiotic environment. At different concentrations, fatty acids can partition between several different phases, including soluble monomers, micelles, and lamellar vesicles, with higher concentrations favoring larger vesicle aggregates. We have exploited this property to show experimentally that evaporation can cause vesicles to grow by increasing the total fatty acid concentration. Rainfall could then cause turbulence and dilution, leading to the division of some vesicles and the dissolution of others. Thus, alternation of evaporation and rain could potentially lead to an environmentally controlled cycle of growth and division.

近期论文

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emplate-directed catalysis of a multi-step reaction pathway for nonenzymatic RNA primer extension Walton T, Pazienza L, Szostak JW. Biochemistry. 2018 Dec . Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA Kim SC, O'Flaherty DK, Zhou L, Lelyveld VS, Szostak JW . Proc Natl Acad Sci U S A. 2018 Dec PDF . Catalysis of Template-directed Nonenzymatic RNA Copying by Iron (II) Jin L, Engelhart AE, Zhang W, Adamala KP, Szostak JW . J Am Chem Soc. 2018 Nov PDF. Protocells and RNA Self-Replication Joyce GF and Szostak JW . Cold Spring Harb Perspect Biol. 2018 Sept . A Fluorescent G-Quadruplex Sensor for Chemical RNA Copying Giurgiu C, Wright TH, O'Flaherty DK, Szostak JW . Angew Chem Int Ed Engl. 2018 June . Crystallographic observation of nonenzymatic RNA primer extension Zhang W, Walton T, Li L, Szostak JW . Elife. 2018 May PDF. Copying of Mixed-Sequence RNA Templates inside Model Protocells O'Flaherty DK, Kamat NP, Mirza FN, Li L, Prywes N, Szostak JW . J Am Chem Soc. 2018 April PDF. Preparation, Purification, and Use of Fatty Acid-containing Liposomes Jin L, Engelhart AE, Adamala KP, Szostak JW . J Vis Exp. 2018 Feb PDF. Fatty Acid/Phospholipid Blended Membranes: A Potential Intermediate State in Protocellular Evolution Jin L, Kamat NP, Jena S, Szostak JW . Small. 2018 Feb PDF. Structural Rationale for the Enhanced Catalysis of Nonenzymatic RNA Primer Extension by a Downstream Oligonucleotide Zhang W, Tam CP, Zhou L, Oh SS, Wang J, Szostak JW . J Am Chem Soc. 2018 Feb PDF. Solvated-electron production using cyanocuprates is compatible with the UV-environment on a Hadean-Archaean Earth Todd ZR, Fahrenbach AC, Manani CJ, Ranjan S, Björkbom A, Szostak JW, Sasselov DD . Chem Commun (Camb). 2018 Jan PDF. Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. J Am Chem Soc. 2018 Jan PDF. A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension Giurgiu C, Li L, O'Flaherty DK, Tam CP, Szostak JW. J Am Chem Soc. 2017 Nov PDF. A kinetic model of nonenzymatic RNA polymerization by cytidine-5'-phosphoro-2-aminoimidazolide Walton T, Szostak JW. Biochemistry. 2017 Oct PDF. Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution Ransey E, Björkbom A, Lelyveld VS, Biecek P, Pantano L, Szostak JW, Sliz P. RNA Biol. 2017 Sep PDF. UV-light-driven prebiotic synthesis of iron‒sulfur clusters Bonfio C, Valer L, Scintilla S, Shah S, Evans DJ, Jin L, Szostak JW, Sasselov DD, Sutherland JD, Mansy SS. Nat Chem. 2017 Jul . Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Proc Natl Acad Sci U S A. 2017 Jul PDF. Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation Fahrenbach AC, Giurgiu C, Tam CP, Li L, Hongo Y, Aono M, Szostak JW. J Am Chem Soc. 2017 Jul PDF. Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides Stairs S, Nikmal A, Bučar DK, Zheng SL, Szostak JW, Powner MW. Nat Commun. 2017 May PDF. The Narrow Road to the Deep Past: In Search of the Chemistry of the Origin of Life Szostak JW. Angew Chem Int Ed Engl. 2017 Sep. Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides Li L, Prywes N, Tam CP, O'Flaherty DK, Lelyveld VS, Izgu EC, Pal A, Szostak JW. J Am Chem Soc. 2017 Mar. PDF. Downstream Oligonucleotides Strongly Enhance the Affinity of GMP to RNA Primer-Template Complexes Tam CP, Fahrenbach AC, Björkbom A, Prywes N, Izgu EC, Szostak JW. J Am Chem Soc. 2017 Jan. PDF.