赵晶 - 湖北大学 - 生命科学学院

个人简介

学习和工作简历： l2004年9月-2008年7月，南京农业大学，获工学学士学位 l2008年9月-2011年6月，华东理工大学，获工学硕士学位 l2011年10月-2015年9月，德国亚琛工业大学（RWTHAachenUniversity），获理学博士学位 l2015年12月-2018年12月，中国科学院天津工业生物技术研究所，助理研究员 l2019年1月-2019年7月，湖北大学生命科学学院，讲师 l2019年7月至今，湖北大学生命科学学院，副教授承担科研项目情况： 1.国家自然科学基金（21606251）：赖氨酸脱羧酶多聚体界面氨基酸对酶活性和最适pH影响规律的研究；2017.01-2019.12，主持。 2.天津市自然科学基金（18JCQNJC10300）：手性砌块反式-4-羟基-L-脯氨酸生物法绿色制造关键酶的多目标分子进化与应用研究；2018.04-2021.03，主持。 3.天津市留学人员科技活动启动项目择优资助（2017年度）：同时进化酶的可溶性和活性获得新型赖氨酸脱羧酶的研究，2018.01-2018.12，主持。 4.国家自然科学基金（31870081）：以异亮氨酰-tRNA合成酶为例构建一类新型氨基酸生物传感器；2019.01-2022.12，参与。

近期论文

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1.JingZhao#,ChaoLiu#,XuanGuo#,JinyuWang,HaipingLiu,PingZheng*,JibinSun*,YanheMa.Efficientproductionoftrans-3-hydroxyprolinebyabacterialtrans-3-prolinehydroxylaseandcharacterizationofenzymaticproperties.BiochemicalEngineeringJournal,2019,147:57–61. 2.ChaoLiu#,JingZhao#(#equalcontribution),JiaoLiu,XuanGuo,DemingRao,HaipingLiu,PingZheng*,JibinSun*,YanheMa.Simultaneouslyimprovingtheactivityandthermostabilityofanewproline4-hydroxylasebyloopgraftingandsite-directedmutagenesis,AppliedMicrobiologyandBiotechnology,2019,103:265–277. 3.JingZhao,VictorineJosianeFrauenkron-Machedjou,AlexanderFulton,LeileiZhu,MehdiD.Davari,Karl-ErichJaeger,UlrichSchwaneberg*,MarcoBocola*,Unravelingtheeffectsofaminoacidsubstitutionsenhancinglipaseresistancetoanionicliquid:amoleculardynamicsstudy,PhysicalChemistryChemicalPhysics,2018,20(14):9600–9609. 4.JingZhao,VictorineJosianeFrauenkron-Machedjou,TsvetanKardashliev,AnnaJoëlleRuff,LeileiZhu,MarcoBocola,UlrichSchwaneberg*.Aminoacidsubstitutionsinrandommutagenesislibraries:lessonsfromanalyzing3000mutations.AppliedMicrobiologyandBiotechnology,2017,101(8):3177–3187. 5.JingZhao,NingJia,Karl-ErichJaeger,MarcoBocola,UlrichSchwaneberg*.IonicliquidactivatedBacillusSubtilislipaseAvariantsthroughcooperativesurfacesubstitutions.BiotechnologyandBioengineering,2015,112(10):1997–2004. 6.JingZhao,TsvetanKardashliev,AnnaJoëlleRuff,MarcoBocola,UlrichSchwaneberg*.Lessonsfromdiversityofdirectedevolutionexperimentsbyananalysisof3,000mutations.BiotechnologyandBioengineering,2014,111(12):2380–2389. 7.JingZhao,YanyanChu,AitaoLi,XinJu,XudongKong,JiangPan,YunTang*,JianheXu*.Anunusual(R)-selectiveepoxidehydrolasewithhighactivityforfacilepreparationofenantiopureglycidylethers.AdvancedSynthesis&Catalysis,2011,353(9):1510–1518. 8.FengyuKou#,JingZhao#(#equalcontribution),JiaoLiu,JieShen,QinYe,PingZheng,ZhiminLi*,JibinSun*,YanheMa.CharacterizationofanewlysinedecarboxylasefromAliivibriosalmonicidaforcadaverineproductionatalkalinepH.JournalofMolecularCatalysisB:Enzymatic,2016,133(Supplement1):S88–S94. 9.ZijianTan,JingZhao#(#equalcontribution),JiuzhouChen,DemingRao,WenjuanZhou,NingChen,PingZheng*,JibinSun,YanheMa.EnhancingthermostabilityandremovinghemininhibitionofRhodopseudomonaspalustris5-aminolevulinicacidsynthasebycomputer-aidedrationaldesign.BiotechnologyLetters,2019,41:181–191. 10.DeyuXu#,JingZhao#(#equalcontribution),GuoqiangCao,JinyuWang,QinggangLi,PingZheng*,ShuxinZhao,JibinSun.RemovaloffeedbackinhibitionofCorynebacteriumglutamicumphosphoenolpyruvatecarboxylasebyadditionofashortterminalpeptide.BiotechnologyandBioprocessEngineering,2018,23(1):72–78. 11.JiaoLiu,YuWang,YujiaoLu,XiaomengNi,XuanGuo,JingZhao,JiuzhouChen,TaiwoDele-Osibanjo,PingZheng,JibinSun*,YanheMa.MutationsonpeptidoglycansynthesisgeneponAimproveelectro-transformationefficiencyofCorynebacteriumglutamicumATCC13869,AppliedandEnvironmentalMicrobiology,2018,84(24)e02225-18. 12.RenjieLi,AitaoLi,JingZhao,QiChen,NingLi,HuileiYu*,JianheXu.EngineeringP450LaMOstereospecificityandproductselectivityforselectiveC-Hoxidationoftetralin-likealkylbenzenes.CatalysisScience&Technology,2018,8:4638–4644. 13.GuochaoXu,YueWang,MinghuiTang,JieyuZhou,JingZhao,RuizhiHan,YeNi*.Hydroclassifiedcombinatorialsaturationmutagenesis:reshapingsubstratebindingpocketsofKpADHforenantioselectivereductionofbulky-bulkyketones.ACSCatalysis,2018,8:8336–8345. 14.RenjieLi,JianheXu*,QiChen,JingZhao,AitaoLi,HuileiYu*,EnhancingthecatalyticperformanceofaCYP116Bmonooxygenasebytransdomaincombinationmutagenesis.ChemCatChem,2018,10(14):2962–2968. 15.XingchuWang#,JiaoLiu#,JingZhao,XiaomengNi,PingZheng,XuanGuo,CunminSun,JibinSun*,YanheMa,Efficientproductionoftrans-4-hydroxy-L-prolinefromglucoseusinganewtrans-proline4-hydroxylaseinEscherichiacoli.JournalofBioscienceandBioengineering,2018,126(4):470–477. 16.FengyuKou,JingZhao,JiaoLiu,CunminSun,YanmeiGuo,ZijianTan,FengCheng,ZhiminLi,PingZheng*,JibinSun,EnhancementofthethermalandalkalinepHstabilityofEscherichiacolilysinedecarboxylaseforefficientcadaverineproduction.BiotechnologyLetters,2018,40(4):719–727. 17.UlrichMarkel,LeileiZhu,VictorineJosianeFrauenkron-Machedjou,JingZhao,MarcoBocola,MehdiD.Davari,Karl-ErichJaeger,UlrichSchwaneberg*.Aredirectedevolutionapproachesefficientinexploringnature’spotentialtostabilizealipaseinorganiccosolvents?Catalysts,2017,7(5):142. 18.HaoCao,ChengchengLi,JingZhao,FangWang,TianweiTan,LuoLiu*.EnzymaticproductionofglutathionecouplingwithanATPregenerationsystembasedonpolyphosphatekinase.AppliedBiochemistryandBiotechnology,2018,185(2):385–395. 19.XiangLiu,JianheXu*,JiangPan,JingZhao.Efficientproductionof(S)-naproxenwith(R)-substraterecyclingusinganoverexpressedcarboxylesteraseBsE-NP01.AppliedBiochemistryandBiotechnology,2010,162:1574–1584. 20.VictorineJosianeFrauenkron-Machedjou,AlexanderFulton,JingZhao,LinaWeber,Karl-ErichJaeger,UlrichSchwaneberg,LeileiZhu*.Exploringthefullnaturaldiversityofsingleaminoacidexchangerevealsthat40–60%ofBSLApositionsimproveorganicsolventsresistance.BioresourcesandBioprocessing,2018,5:2. 21.TsvetanKardashliev,AnnaJoëlleRuff,JingZhao,UlrichSchwaneberg*.Ahigh-throughputscreeningmethodtoreengineerDNApolymerasesforrandommutagenesis.MolecularBiotechnology,2014,56(3):274–283. 22.曲戈,赵晶,郑平,孙际宾,孙周通*.定向进化技术的最新进展.生物工程学报,2018,34(1):1–11. 23.赵晶,鞠鑫,潘江,李春秀,王敏杰,许建和*.毛白杨环氧水解酶的异源表达及其在催化拆分手性环氧化物中的应用.催化学报,2012,33(2):302–307.

个人简介

研究领域

近期论文