O'Shea, Erin - Harvard University - Department of Chemistry and Chemical Biology

个人简介

Erin O'Shea is an investigator for Howard Hughes Medical Institute and the Paul C. Mangelsdorf of Molecular and Cellular Biology and of Chemistry and Chemical Biology. She received a Ph.D. in chemistry from MIT with Peter Kim and then did postdoctoral work with Robert Tjian at UC Berkeley and with Ira Herskowitz at UC San Francisco before beginning a faculty position at UC San Francisco in 1993. In 2005, Dr. O'Shea moved to Harvard University. Her lab studies how cells monitor the environment and regulate gene expression, She is also interested in deciphering the logic of signaling and transcriptional control, and in understanding the function and mechanism of oscillation of a three-protein circadian clock. Dr. O'Shea is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the American Academy of Microbiology and has received numerous awards including the National Academy of Sciences Award in Molecular Biology.

研究领域

Biophysics/Chemical Biology

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

A. R. Subramaniam, B. Zid, E. K. O’Shea, An integrated approach reveals regulatory controls on bacterial translation elongation. Cell, 159(5):1200–1211 (2014). Article / Harvard Users B. Zid and E.K. O'Shea, Promoter sequences influence cytoplasmic localization and translation of mRNAs during nutrient limitation. Nature, 514(7520):117-121 (2014). Article / Harvard Users S. Mukherji and E.K. O'Shea, Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance. eLife, 2014;3:e02678 (2014). Article A. R. Subramaniam, A. DeLoughery, N. Bradshaw, Y. Chen, E. K. O’Shea, R. Losick, Y. Chai. A serine sensor for multicellularity in a bacterium, eLife, 2013;2:e01501 (2013). Article J.S. Markson*, J.R. Piechura*, A.M. Puszynska and E.K. O'Shea, Circadian control of global gene expression by the cyanobacterial master regulator RpaA, Cell, 155:6, pages 1396-1408 (2013). (* equal contribution) PubMed A.S. Hansen and E.K. O'Shea, Promoter Decoding of Transcription Factor Dynamics Involves a Trade-Off between Noise and Control of Gene Expression, Molecular Systems Biology, 9:704 (2013). PubMed News & Views S.W. Teng, S. Mukherji, J.R. Moffitt, S. de Buyl and E.K. O'Shea, Robust circadian oscillations in growing cyanobacteria require transcriptional feedback, Science, 340(6133) , pp. 737-740 (2013). PubMed A. Gutu and and E.K. O'Shea, Two antagonistic clock-regulated histidine kinases time the activation of circadian gene expression, Molecular Cell, 50(2), pp. 288-294 (2013). PubMed V. Vijayan and and E.K. O'Shea, Sequence determinants of circadian gene expression in cyanobacteria, Journal of Bacteriology, 195(4), pp. 665-671 (2013). PubMed N. Hao, B.A. Budnik, J. Gunawardena and E.K. O'Shea, Tunable signal processing through modular control of transcription factor translocation, Science 339(460), pp. 460-464 (2013). PubMed I. Carter-O'Connell, M.T. Peel, D.D. Wykoff, and E.K. O'Shea, Genome-Wide Characterization of the Phosphate Starvation Response in Schizosaccharomyces Pombe, BMC Genomics, 13: 697 (2012). PubMed C. L. Grimes, L. De Zoysa Ariyanada, J. Melnyk and E.K. O'Shea, The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment, Journal of the American Chemical Society, 134(33) , pp. 13535-13537 (2012). PubMed I. Jain, V. Vijayan and E.K. O'Shea, Spatial ordering of chromosomes enhances the fidelity of chromosome partitioning in cyanobacteria, Proc. Natl. Acad. Sci USA, 109(34) , 13638-43 (2012). PubMed K. Cook and E.K. O'Shea, Hog1 controls global reallocation of RNA Pol II upon osmotic shock in Saccharomyces cerevisiae,G3: Genes, Genomes, Genomics, 2(9) , pp. 1129-36.(2012). PubMed N. Hao and E.K. O'Shea, Signal-dependent dynamics of transcription factor translocation controls gene expression, Nature Structural and Molecular Biology, 19(1):31-39 (2012). X. Zhou and E.K. O'Shea, Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4, Molecular Cell, 42(6):826-36 (2011). PubMed V. Vijayan, I. H. Jain, E. K. O'Shea, A high resolution map of a cyanobacterial transcriptome, Genome Biology, 12:R47 (2011). PubMed