Myers, Andrew - Harvard University - Department of Chemistry and Chemical Biology

个人简介

Andrew G. Myers graduated from MIT in 1981 with a Bachelor of Science degree. He was introduced to chemical research as an undergraduate in the laboratory of Professor William R. Roush, and went on to study with Professor E.J. Corey from 1981-1986 at Harvard University, both as a graduate student and then briefly as a postdoctoral researcher. Myers began his independent academic career at Caltech (1986), where he was Assistant, Associate, and then Full Professor (1994). In 1998, he moved to the Department of Chemistry and Chemical Biology at Harvard University, served as Chair of the Department from 2007-2010, and is currently Amory Houghton Professor of Chemistry.

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(147) Kevin Pröpper, Birger Dittrich, Daniel J. Smaltz, Thomas Magauer, and Andrew G. Myers. Crystalline Guanine Adducts of Natural and Synthetic Trioxacarcins Suggest a Common Biological Mechanism and Reveal a Basis for the Instability of Trioxicarcin A. Bioorganic & Medicinal Chemistry Letters. 2014; 24(18): 4410-4413. Peter M. Wright, Ian B. Seiple, and Andrew G. Myers. The Evolving Role of Chemical Synthesis in Antibacterial Drug Discovery. Angewandte Chemie International Edition. 2014; 53(34): 8840–8869. Ian B. Seiple, Jaron A.M. Mercer, Robin J. Sussman, Ziyang Zhang, and Andrew G. Myers. Stereocontrolled Synthesis of syn-β-Hydroxy-α-Amino Acids by Direct Aldolization of Pseudoephenamine Glycinamide. Angewandte Chemie International Edition. 2014; 53(18): 4642–4647. Landy K. Blasdel, DongEun Lee, Binyuan Sun, and Andrew G. Myers. (S)-4-Trimethylsilyl-3-butyn-2-ol as an Auxiliary for Stereocontrolled Synthesis of Salinosporamide Analogs with Modifications at Positions C2 and C5. Bioorganic & Medicinal Chemistry Letters. 2013; 23(24): 6905–6910. Kevin T. Mellem and Andrew G. Myers. A Simple, Scalable Synthetic Route to (+)- and (–)-Pseudoephenamine. Organic Letters. 2013; 15(21): 5594–5597. Thomas Magauer, Daniel J. Smaltz, and Andrew G. Myers. Component-based Syntheses of Trioxacarcin A, DC-45-A1 and Structural Analogues. Nature Chemistry. 2013; 5(10): 886–893. Cedric L. Hugelshofer, Kevin T. Mellem, and Andrew G. Myers. Synthesis of Quaternary α-Methyl α-Amino Acids by Asymmetric Alkylation of Pseudoephenamine Alaninamide Pivaldimine. Organic Letters. 2013; 15(12): 3134–3137. Marvin R. Morales, Kevin T. Mellem, and Andrew G. Myers. Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis. Angewandte Chemie International Edition. 2012; 51(19): 4568–4571. Daniel J. Smaltz, Jakub Švenda, and Andrew G. Myers. Diastereoselective Additions of Allylmetal Reagents to Free and Protected syn-α, β-Dihydroxyketones Enable Efficient Synthetic Routes to Methyl Trioxacarcinoside A. Organic Letters. 2012; 14(7): 1812–1815. Peter M. Wright and Andrew G. Myers. Methodological Advances Permit the Stereocontrolled Construction of Diverse Fully Synthetic Tetracyclines Containing an All-Carbon Quaternary Center at Position C5a. Tetrahedron. 2011; 67(51): 9853–9869. Chong Si and Andrew G. Myers. A Versatile Synthesis of Substituted Isoquinolines. Angewandte Chemie International Edition. 2011; 50(44): 10409–10413. Daniel J. Smaltz and Andrew G. Myers. Scalable Synthesis of Enantiomerically Pure syn-2,3-Dihydroxybutyrate by Sharpless Asymmetric Dihydroxylation of p-Phenylbenzyl Crotonate. Journal of Organic Chemistry. 2011; 76(20): 8554–8559. Thomas Magauer and Andrew G. Myers. Short and Efficient Synthetic Route to Methyl α-Trioxacarcinoside B and Anomerically Activated Derivatives. Organic Letters. 2011; 13(20): 5584–5587. Rebecca L. Simmons, Robert T. Yu, and Andrew G. Myers. Storable Arylpalladium(II) Reagents for Alkene Labeling in Aqueous Media. Journal of the American Chemical Society. 2011; 133(40): 15870–15873. David A. Kummer, Derun Li, Amelie Dion, and Andrew G. Myers. A Practical, Convergent Route to the Key Precursor to the Tetracycline Antibiotics. Chemical Science. 2011; 2(9): 1710–1718. Jakub Švenda, Nicholas Hill, and Andrew G. Myers. A Multiply Convergent Platform for the Synthesis of Trioxacarcins. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(17): 6709–6714. Alec N. Flyer, Chong Si, and Andrew G. Myers. Synthesis of Cortistatins A, K, J, and L. Nature Chemistry. 2010; 2(10): 886–892. Jakub Švenda and Andrew G. Myers. Anti-Selective Epoxidation of Methyl α-Methylene-β-tert-butyldimethylsiloxycarboxylate Esters. Evidence for Stereospecific Oxygen Atom Transfer in a Nucleophilic Epoxidation Process. Organic Letters. 2009; 11(11): 2437–2440. Sang Min Lim, Nicholas Hill, and Andrew G. Myers. A Method for the Preparation of Differentiated trans-1,2-Diol Derivatives with Enantio- and Diastereocontrol. Journal of the American Chemical Society. 2009; 131(16): 5763–5765. Cuixiang Sun, Qui Wang, Jason D. Brubaker, Peter M. Wright, Christian D. Lerner, Kevin Noson, Mark Charest, Dionicio R. Siegel, Yi-Ming Wang, and Andrew G. Myers. A Robust Platform for the Synthesis of New Tetracycline Antibiotics. Journal of the American Chemical Society. 2008; 130(52): 17913–17927. David A. Kummer, William J. Chain, Marvin R. Morales, Olga Quiroga, and Andrew G. Myers. Stereocontrolled Alkylative Construction of Quaternary Carbon Centers. Journal of the American Chemical Society. 2008; 130(40): 13231–13233.

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