Liu, David R. - Harvard University - Department of Chemistry and Chemical Biology

个人简介

David R. Liu is Professor of Chemistry and Chemical Biology at Harvard University, a Howard Hughes Medical Institute Investigator, and a Senior Associate Member of the Broad Institute of Harvard and MIT. Liu was born in 1973 in Riverside, California. He performed research on sterol biosynthesis under Professor E. J. Corey's guidance throughout his undergraduate years. Liu graduated first in his class at Harvard in 1994 with a bachelor's degree in chemistry before entering the Ph.D. program at U. C. Berkeley. In the group of Professor Peter Schultz, Liu initiated the first general effort to expand the genetic code in living cells. He earned his Ph.D. in 1999 and became Assistant Professor of Chemistry and Chemical Biology at Harvard University in the same year. He was promoted to Associate Professor in 2003 and to Full Professor in 2005. Liu was also appointed as a Howard Hughes Medical Institute Investigator in 2005 and joined the JASONs, academic advisors to the U.S. government on science and technology, in 2009. Liu has taught more than 2,500 undergraduates and graduate students in the classroom, and has earned three university-wide distinctions for undergraduate and graduate student teaching at Harvard, including the Joseph R. Levenson Memorial Teaching Prize in 2007, the Roslyn Abramson Award in 2003, and a Harvard College Professorship in 2007. His undergraduate and graduate students have earned university-wide and national distinctions for their thesis research, including three Thomas T. Hoopes prizes and one Lawrence J. Henderson Prize at Harvard, the IUPAC Prize for Young Chemists, the Harold W. Weintraub Graduate Student Award, and the Fannie and John Hertz Foundation Doctoral Thesis Prize. Liu has published more than 100 papers in chemical biology, molecular biology, and organic chemistry. His research accomplishments have earned distinctions including the American Chemical Society Pure Chemistry Award (2006), the American Chemical Society Arthur C. Cope Young Scholar Award (2004), the Glaxo-Smith-Kline Chemistry Scholar Award (2004), the AstraZeneca Pharmaceuticals Excellence in Chemistry Award (2003), the Sloan Foundation Fellowship (2002), the Beckman Foundation Young Investigator Award (2002), the NSF CAREER Award (2001), the Searle Scholars Award (2000), and the Office of Naval Research Young Investigator Award (2000). Professor Liu’s research applies evolutionary principles to the study and manipulation of biological and synthetic molecules. His major research interests include (i) the evolution, delivery, and characterization of synthetic regulatory elements, macromolecules that precisely manipulate information flow in human cells; (ii) discovery of new structures and functions among cellular nucleic acids; and (iii) the discovery of bioactive synthetic small molecules, functional synthetic polymers, and new chemical reactions through DNA-templated organic synthesis, a technique developed in his laboratory, and in vitro selection.

研究领域

Bioorganic/Chemical/Biology/Organic/Origins of Life

近期论文

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The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules. Gartner, Z. J. and Liu, D. R. J. Am. Chem. Soc. 123, 6961-6963 (2001). An In Vivo Selection System for Homing Endonuclease Activity. Gruen, M.; Chang, K.; Serbanescu, I.; Liu, D. R. Nucleic Acids Research 30, e29 (2002). Recent Advances in the In Vitro Evolution of Nucleic Acids. Bittker, J. A.; Phillips, K. J.; Liu, D. R. Curr. Opin. Chem. Biol., 6, 367-374 (2002). Expanding the Reaction Scope of DNA-Templated Synthesis. Gartner, Z, J.; Kanan, M. W.; Liu, D. R. Angew. Chem. Int. Ed., 41, 1796-1800 (2002). Nucleic Acid Evolution and Minimization by Nonhomologous Random Recombination. Bittker, J. A.; Le, B. V.; Liu, D. R. Nature Biotechnology 20, 1024-1029 (2002). Multistep Small-Molecule Synthesis Programmed by DNA Templates. Gartner, Z. J.; Kanan, M. W.; Liu, D. R. J. Am. Chem. Soc., 124, 10304-10306 (2002). Directing Otherwise Incompatible Reactions in a Single Solution Using DNA-Templated Organic Synthesis. Calderone, C. T.; Puckett, J. W.; Gartner, Z. J.; Liu, D. R. Angew. Chem. Int. Ed. 41, 4104-4108 (2002). Two Enabling Architectures for DNA-Templated Organic Synthesis. Gartner, Z. J.; Grubina, R.; Calderone, C. T.; Liu, D. R. Angew. Chem. Int. Ed. 42, 1370-1375 (2003). In Vivo Evolution of an RNA Transcriptional Activator. Buskirk, A. R.; Kehayova, P. D.; Landrigan, A.; Liu, D. R. Chem. Biol. 10, 533-540 (2003). Stereoselectivity in DNA-Templated Organic Synthesis and Its Origins. Li, X. and Liu, D. R. J. Am. Chem. Soc. 125, 10188-10189 (2003). Highly Sensitive In Vitro Selections for DNA-Linked Synthetic Small Molecules with Protein Binding Affinity and Specificity. Doyon, J. B.; Snyder, T. M.; Liu, D. R. J. Am. Chem. Soc. 125, 12372-12373 (2003). Efficient and Sequence-Specific DNA-Templated Polymerization of PNA Aldehydes. Rosenbaum, D. M. and Liu, D. R. J. Am. Chem. Soc. 125, 13924-13925 (2003). Expanding the Genetic Code In Vitro and In Vivo. Magliery, T. J.; Liu, D. R. The Genetic Code and the Origin of Life Ed. Ribas de Pouplana, L. Landes Bioscience and Springer, (2004). Translation of DNA into Synthetic N-Acyloxazolidines. Li, X.; Gartner, Z. J.; Tse, B. N.; Liu, D. R. J. Am. Chem. Soc. 126, 5090-5092 (2004). Directed Evolution of Protein Enzymes Using Nonhomologous Random Recombination. Bittker, J. A.; Le, B. V.; Liu, J. M.; Liu, D. R. Proc. Natl. Acad. Sci. USA 101, 7011-7016 (2004). DNA-Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules. Li, X.; Liu, D. R. Angew. Chem. Int. Ed. 43, 4848-4870 (2004). Directed Evolution of Ligand Dependence: Small Molecule-Dependent Protein Splicing. Buskirk, A. R.; Ong, Y.-C.; Gartner, Z. J.; Liu, D. R. Proc. Natl. Acad. Sci. USA 101, 10505-10510 (2004). DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles. Gartner, Z. J.; Tse, B. N.; Grubina, R.; Doyon, J. B.; Snyder, T. M.; Liu, D. R. Science 305, 1601-1605 (2004). Engineering a Ligand-Dependent RNA Transcriptional Activator. Buskirk, A. R.; Landrigan, A.; Liu, D. R. Chem. Biol. 11, 1157-1163 (2004). Reaction Discovery Enabled by DNA-Templated Synthesis and In Vitro Selection. Kanan, M. W.; Rozenman, M. M.; Sakurai, K.; Snyder, T. M., Liu, D. R. Nature 431, 545-549 (2004).