McMillin, David R. - Purdue University - Department of Chemistry

个人简介

B.A., 1969 Knox College; PhD., 1973, University of Illinois.

研究领域

We know a great deal about the ground states of molecules, but electronic excited states present many new challenges. The electronic excited states of transition metal complexes, especially late transition metal complexes, are a major research interest of the McMillin group. Because late transition metal systems typically have vacant coordination sites, exciplex (excited state complex) formation is an important process, and the excited states are quite sensitive to the local environment. In addition to temperature and pressure sensing, it is possible to study DNA-binding interactions by luminescence spectroscopy. For example, water-soluble, cationic porphyrins are versatile DNA-binding agents that could be useful in photodynamic therapy, a treatment that ultimately uses visible radiation to destroy diseased cells. For the model system Cu(TMPyP4), the luminescence spectrum reveals whether the complex intercalates or binds in a more exposed external fashion; see the Figure. Studies with hairpin-forming DNA strands are yielding important information about the sequence selectivity of the mode of binding. Other DNA-binding studies revolve around planar platinum(II) chromophores, especially systems containing terpyridine ligands. Here, the emission is also subject to exciplex quenching, but other effects influence the excited-state lifetime as well

近期论文

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Lewis Acid and Base Sensing by Platinum(II) Polypyridines; McGuire, R., Jr.; Wilson, M. H.; Nash, Fanwick,P. E.; and McMillin, D. R. Inorg. Chem. 2008, 47, 2946-2948. When One Configuration is Not Enough; McMillin, D. R. J. Chem. Educ. 2008, 85, 859-862. A pared-down version of 5,10,15,20-tetra(N-methylpyridinium-4-yl)porphyrin intercalates into B-form DNA regardless of base composition: Binding studies of tri(N-methylpyridinium-4-yl)porphyrins, Andrews,K.; and McMillin,D. R. Biochemistry 2008, 47, 1117-1125. Synthesis, electrochemistry and luminescence of [Pt{4'-(R)-trpy}(CN)]+ (R = Ph, o-CH3-Ph, o-Cl-Ph or o-CF3-Ph; trpy = 2,2':6',2''-terpyridine): Crystal structure of [Pt{4'-(Ph)-trpy}(CN)]BF4*CH3CN. Field, J. S.; Haines, R. J.; Ledwaba, L. P.; McGuire, R., Jr.; Munro, O. Q.; Low, M. R.; McMillin, D. R. Dalton Trans. 2007, 192-199. Understanding Binding Interactions of Cationic Porphyrins with B-form DNA. McMillin, D. R.; Shelton, A. H.; Bejune, S. A.; Fanwick, P. E.; Wall, R. K. Coord. Chem. Rev. 2005, 249, 1451-1459. Push-Pull Effects and Emission from Ternary Complexes of Platinum (II), Substituted Terpyridines; and the Strong-Field Cyanide Iron. Wilson, M. H.; Ledwaba, L. P.; Field, J. S.; McMillin, D. R. Dalton Trans., 2005, 2754-2759. One-dimensional supramolecular assemblies based on a Re2(III,III) synthon and their solid-state phosphorescence, Dequeant, M. Q.; McGuire, R., Jr.; McMillin, D. R.; Ren, T. Inorg. Chem. 2005, 44, 6521-6523. A luminescent Pt(II) complex with a terpyridine-like ligand involving a six-membered chelate ring, Hu, Y.Z.; Wilson, M.H.; Zong, R.F.; Bonnefous, C.; McMillin, D.R.; Thummel, R.P. Dalton Trans. 2005, 354-358. The Influence of the loop sequence in binding studies involving cationic porphyrins and DNA hairpins, Bejune, S. A.; McMillin, D. R. Chem Comm. 2004, 1320-1321. New Dicatonic Porphyrin Ligands Suited for Intercalation into B-Form DNA, Bejune, S. A.; Shelton, A. H.; McMillin, D. R. Inorg. Chem. 2003, 42, 8464-8475. Temperature Dependence of the Crystal Structure and Luminescence Properties of [Pt{4'-(o-ClC6H4)trpy}Cl]SbF6 (trpy = 2,2':6',2"-terpyridine), Field, J. S.; Gertenbach, J. A.; Haines, R. J.; Ledwaba, L. P.; Mashapa, N. T.; McMillin, D. R.; Munro, O. Q.; Summerton, G. C. J. Chem. Soc., Dalton Trans. 2003, 1176-1180. Luminescence that Lasts from Pt(trpy)Cl+ Derivatives (trpy = 2,2N:6N,2O-terpyridine), McMillin, D. R.; Moore, J. J. Coord. Chem. Rev. 2002, 229,113-121. Synthesis and Structural Characterization of Cu(I) and Ni(II) Complexes that Contain the Bis[2-(diphenylphosphino)phenyl]ether Ligand. Novel Emission Properties for the Cu(I) Species, Kuang, S.; Cuttell, D. G.; McMillin, D. R.; Fanwick, P. E.; Walton, R. A. Inorg. Chem. 2002, 41, 3313-3322. A Superior Polypyridine Ligand for Platnium(II) Lumaphors. Methyl Substituents With a Large Stereoelectronic Influence, Moore, J. J.; Nash, J. J.; Fanwick, P. E.; McMillin, D. R. Inorg. Chem. 2002, 41, 6387-6396. Competitive Binding Studies of H2T4 with DNA Hairpins (H2T4 = meso-tetrakis(4-(N-methylpridiniumyl)), Thomas, K. E.; McMillin, D. R. J. Phys. Chem. B 2001, 105, 12628-12633. Simple Cu(I) Complexes with Unprecedented Excited-State Lifetimes, Cuttell, D. G.; Kuang, S. M.; Fanwick, P. E.; McMillin, D. R. Walton, R. A. J. Am. Chem. Soc. 2001, 124, 6-7.