个人简介

B.S.- M.S. Bucknell University (1966) Ph.D. Rockefeller University (1972) Associate, Rockefeller University (1972-73)

研究领域

Organic

Smith's research interests encompass three diverse areas: natural product synthesis, bioorganic chemistry and materials science. To date, more than 90 architecturally complex natural products having significant bioregulatory properties have been prepared in his Laboratory. In addition, Smith, in collaboration with Ralph Hirschmann, has achieved the design and synthesis of non-peptide peptidomimetics of neuropeptideic hormone/transmitters and protease enzyme inhibitors and, also with Stephen Benkovic (Penn State), haptens for the production of catalytic antibodies capable of peptide bond formation. At Monell, in collaboration with Peter Jurs (Penn State), he pioneered the use of computerized pattern recognition techniques for the analysis of primate chemical communication. Collaborative programs at the LRSM include the chemistry and physics of novel liquid crystals and the fullerenes. To date Smith research achievements have been reported in more than 500 peer reviewed publications.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

J. B. Munro, J. Gorman, X. Ma, J. Arthos, D. R. Burton, W. C. Koff, J. R. Courter, A. B. Smith, III, P. D. Kwong, S. C Blanchard and W. Mothes. Conformational Dynamics of Single HIV-1 Env Trimers on the Surface of Native Virions. Science 2014. (in press). X. Wang, L. Liu, L. Huang, K. Herbst-Robinson, A.-S. Cornec, M. James, S. Sugiyama, M. Bassetto, A. Brancale, J. Q. Trojanowski, V. M.-Y. Lee, A. B. Smith, III, K. R. Brunden and C. Ballatore. Potent, Long-Acting Cyclopentane-1,3-dione Thromboxane (A2)-Receptor Antagonists. ACS Med. Chem. Lett. 2014, 5, 1015-1020. C. Ballatore, B. Gay, L. Huang, K. H. Robinson, M. James, J. Q. Trojanowski, V. M.-Y. Lee, K. R. Brunden and A. B. Smith, III. Evaluation of the cyclopane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorg. Med. Chem. Lett. 2014, 24, 4175-4177. PMC4146692. K. Lou, Y. Yao, A. Hoye, M. James, A.-S. Cornec, E. Hyde, B. Gay, V. M.-Y. Lee, J. Q. Trojanowski, A. B. Smith, III, K. R. Brunden and C. Ballatore. Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules as Potential Candidates for the Treatment of Alzheimer’s Disease and Related Tauopathies. J. Med. Chem. 2014, 47, 6116-6127. PMC4111403. J. R. Courter, N. Madani, J. Sodroski, A. Schon, E. Freire, P. D. Kwong, W. A. Hendrickson, I. M. Chaiken, J. M. LaLonde and A. B. Smith, III. Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist. Acc. Chem. Res. 2014, 47, 1228-1237. PMC3993944. K. Vougogiannopoulou, C. Lemus, M. Halabalaki, C. Pergola, O. Werz, A. B. Smith, III, S. Michel, L. Skaltsounis and B. Deguin. One-Step Semisynthesis of Oleacein and its Identification as 5-lipoxygenase Inhibitor. J. Nat. Prod. 2014, 77, 441-445. (Not NIH Funded). N. Madani, A. M. Princiotto, A. Schön, J. LaLonde, Y. Feng, E. Freire, J. Parks, J. Courter, D. Jones, J. Robinson, H.-X. Liao, M. A. Moody, S. Permar, B. Haynes, A. B. Smith, III, R. Wyatt and J. Sodroski. CD4-Mimetic Small Molecules Sensitize Human Immunodeficiency Virus (HIV-1) to Vaccine-Elicited Antibodies. J. Virol. 2014, 88, 6542-6555. M. H. Nguyen and A. B. Smith, III. Recyclable Polystyrene-Supported Siloxane-Transfer Agent for Palladium-Catalyzed Cross-Coupling Reactions. Org. Lett. 2014, 16, 2070-2073. PMC3993864. K. R. Brunden, J. Q. Trojanowski, A. B. Smith, III, V. M.-Y. Lee and C. Ballatore. Microtubule-Stabilizing Agents as Potential Therapeutics for Neurodegenerative Disease. Bioorg. Med. Chem. 2014, 13, 01054-7. NIHMSID556452. Y. D. Kwon, J. M. LaLonde, Y. Yang, M. A. Elban, A. Sugawara, J. R. Courter, D. M. Jones, A. B. Smith, III, A. K. Debnath and P.D. Kwong. Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues that Target the CD4 Binding Site. PLoS One. 2014, 9, e85940. PMC3904841. M. Z. Chen, O. Gutierrez and A. B. Smith, III. Through-Bond/Through-Space Anion Relay Chemistry Exploiting Vinylepoxides as Bifunctional Linchpins. Angew. Chem. Int. Ed. 2014, 53, 1279-1282. PMC3969824. A. Shvartsbart and A. B. Smith, III. Total Synthesis of (−)-Calyciphylline N. J. Am. Chem. Soc. 2014, 136, 870-873. PMC3908864. J. R. Courter, M. Abdo, M. J. Tucker, S. P. Brown, R. M. Hochstrasser and A. B. Smith, III. The Design and Synthesis of Alanine-Rich α-Helical Peptides Constrained by an S,S-Tetrazine Photochemical Trigger: A Fragment Union Approach. J. Org. Chem. 2014, 79, 759-768. PMC3916828. 649. M. H. Nguyen and A. B. Smith, III. Copper-Catalyzed Electrophillic Amination of Organolithium Compounds Mediated by Recoverable Siloxane Transfer Agents. Org. Lett. 2013, 15, 4872-4875. PMC3823690. D. G. Kuroda, M. Abdo, L. Chuntunov, A. B. Smith, III and R. M. Hochstrasser. Vibrational Dynamics of a Non-Degenerate Ultrafast Rotor: The (C12-C13)-Oxalate Ion. J. Chem. Phys. 2013, 139, 164514. PMC3829914. B. D. Williams and A. B. Smith, III. Total Synthesis of (+)-18-epi-Latrunculol A. Org. Lett. 2013, 15, 4584-4587. PMC3826463. M. J. Tucker, M. Abdo, J. R. Courter, J. Chen, S. P. Brown, A. B. Smith, III and R. M. Hochstrasser. Non-Equilibrium Dynamics of Helix Reorganization Observed by Transient 2D IR Spectroscopy. PNAS 2013, 110, 17314-17319. PMC3808647. M. H. Nguyen and A. B. Smith, III. Polymer-Supported Siloxane Transfer Agents for Pd-Catalyzed Cross-Coupling Reactions. Org. Lett. 2013, 15, 4258-4261. PMC3771667. T. Fricke, A. Brandariz-Nunez, X. Wang, A. B. Smith, III and F. Diaz-Griffero. Human Cytosolic Extracts Stabilize the HIV-1 Core. J. Virol. 2013, 87, 10587-10597. PMC3807412. K. R. Brunden, M. J. James, Y. Yao, J. Q. Trojanowski, V. Y.-M. Lee, I. Paterson, C. Ballatore and A. B. Smith, III. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention: Potential Therapeutic Implications. ACS Med. Chem. Lett. 2013, 4, 886-889. A. B. Smith, III. Editorial: Data Integrity. Org. Lett. 2013, 15, 2893-2894. (Not NIH Funded). D. Martinez-Solorio, A. T. Hoye, M. H. Nguyen, and A. B. Smith, III. The Design, Synthesis and Validation of Recoverable and Readily Reusable Siloxane Transfer Agents for Pd-Catalyzed Cross-Coupling Reactions. Org. Lett. 2013, 15, 2454-2457. PMC3762947. B. Melillo and A. B. Smith, III. A Unified Synthetic Strategy to the Cryptocarya Family of Natural Products Exploiting Anion Relay Chemistry (ARC). Org. Lett. 2013, 15, 2282-2285. PMC3671372. C. An, J. A. Jurica, S. P. Walsh, A. T. Hoye and A. B. Smith, III. Total Synthesis of (+)-Irciniastatin A (aka Pysmberin) and (-)-Irciniastatin B. J. Org. Chem. 2013, 78, 4278-4296. PMC3651581. M. Scotece, R. Gómez, J. Conde, V. Lopez, J. J. Gómez-Reino, F. Lago, A. B. Smith, III and O. Gualillo. Oleocanthal inhibits proliferation and (MIP-1α) expression in human multiple myeloma cells. Curr. Med. Chem. 2013, 2467-2475. (Not NIH Funded). D. J. Emerson, B. P. Weiser, J. Psonis, Z. Liao, O. Taratula, A. Fiamengo, X. Wang, K. Sugawara, A. B. Smith, III, R. G. Eckenhoff and I. Dmochowski. Direct Modulation of Microtubule Stability Contributes to Anthracene General Anesthesia. J. Am. Chem. Soc. 2013, 135, 5389-5398. C. Ballatore, A. B. Smith, III, V. M.-Y. Lee, J. Q. Trojanowski and K. R. Brunden. Aminothienopyridazines as Imaging Probes of Tau Pathology: A Patent Evaluation of WO2013090497. Expert Opin Ther Pat. 2014, 24, 355-360. (Not NIH Funded). A. B. Smith, III and J. Potuzak. The 2010 Benjamin Franklin Medal in Chemistry Presented to JoAnne Stubbe. J. Franklin Institute, 2014, 351, 1-11. A. B. Smith, III. Organic Letters Update. Org. Lett. 2014, 16, 1-2.