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个人简介

丁敏,教授,博士生导师,重庆市色谱学会副理事长。1984年毕业于成都科技大学化学系(本科),1988-1991年在重庆医科大学攻读药物分析硕士,获医学硕士学位。1999年8月在香港中文大学参加暑期高级生化学习班。2004年7-12月在日本岛根大学医学部中心实验室研修。获2003年首批重庆市优秀中青年骨干教师资助,第一批重庆高校创新团队临床检验诊断学创新团队成员。 从1984年-至今在重庆医科大学从事生物分析化学的教学和科研工作,主要从事生物活性物质和药物的分析方法的研究,尤其是对HPLC、MS的分析方法的研究。 在EuropeanJournalofHumanGenetics,Analyst,ClinicaChimicaActa、分析化学、中华医学检验杂志等杂志发表论文60余篇,发明专利2项,主、参编6本教材。

研究领域

体内生物活性物质的分析方法研究

主持国家自然科学基金”胆汁酸代谢物轮廓分析用于妊娠肝内胆汁淤积症的诊断和分度”(No:200475069);参加自然科学基金“基因修饰的DC细胞抗HBV研究”项目(No:39970673);主持“尿硫酸化胆汁酸代谢轮廓分析用于妊娠肝内胆汁淤积症诊断和分度”,高等学校博导基金联合资助课题(20115503110013),主持和参与市级和校级多项课题。

近期论文

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WenjingLyu#,XiaoqingZhang#,ZhongZhang,XiaoChen,YingZhou,HongChen,HaoranWang,MinDing*.Asimpleandsensitiveelectrochemicalmethodforthedeterminationofcapsaicinoidsinchillipeppers.Sensors&Actuators:B.Chemical,2019,288:65-70. YueCui,BiaoXu,XiaoqingZhang,YifanHe,YongShao,MinDing,?,Diagnosticandtherapeuticpro?lesofserumbileacidsinwomenwithintrahepaticcholestasisofpregnancy-apseudo-targetedmetabolomicsstudy.ClinicaChimicaActa483(2018)135–141 MingZuoa,,QiannaZhenb,,XiaoqingZhang,WenbiZou,XiangchunYang,GangTian,ZhenghuShi,QifuLi,MinDing,?.Highspeci?cityofspoturinaryfreemetanephrinesindiagnosisandprognosisofpheochromocytomasandparagangliomasbyHPLCwithelectrochemicaldetection.ClinicaChimicaActa478(2018)82–89 .GangTian#,,MinDing#,BiaoXu,YifanHe,WenjingLyu,MingchaoJin,XiaoqingZhang*.Anovelelectrochemicalbiosensorforultrasensitivedetectionofserumtotalbileacidsbasedonenzymaticreactioncombinedwiththedoubleoxidationcircularamplificationstrategy.Biosensors&Bioelectronics,2018,118:31-35. ZhangXiaoqing,ZhuMingsong,XuBiao,YueCui,GangTian,ZhenghuShi,MinDing*Indirectelectrochemicaldetectionfortotalbileacidsinhumanserum.Biosensors&Bioelectronics,2016,85:563-567 MingchaoJin#,XiaoqingZhang#,QianNaZhen,YiFanHe,XiaoChen,WenjingLyu,RunchuanHan,MinDing*.AnelectrochemicalsensorforindoleinplasmabasedonMWCNTs-chitosanmodifiedscreen-printedcarbonelectrode.Biosensors&Bioelectronics,2017,98:392 GangTian,Xiao-QingZhang,Ming-SongZhu,ZhongZhang,Zheng-HuShi,MinDing.Quantificationofethanolinplasmabyelectrochemicaldetectionwithanunmodifiedscreenprintedcarbonelectrode.ScientificReports,|6:23569|DOI:10.1038/srep23569 LiMa,Xiao-QingZhang,Da-XueZhou,YueCui,Lin-LinDeng,TingYang,YongShao,MinDing.FeasibilityofurinarymicroRNAprofilingdetectioninintrahepaticcholestasisofpregnancyanditspotentialasanon-invasivebiomarker ScientificReports,|6:31535|DOI:10.1038/srep31535 JieyingGao,BiaoXub,XiaoqingZhang,YueCui,LinlinDeng,ZhenghuShi,YongShao,MinDing*.Associationbetweenserumbileacidprofilesandgestationaldiabetesmellitus:Atargetedmetabolomicsstudy.ClinicaChimicaActa.2016,459,63-72 XiaoqingZhang,MingsongZhu,BiaoXu,YueCui,GangTian,ZhenghuShi,MinDing*.Indirectelectrochemicaldetectionfortotalbileacidsinhumanserum.BiosensorsandBioelectronics,2016,85,563-567 JieyingGao,JianWang,MingZuo,LiMa,YueCui,TingYang,MinDing*.AhighlysensitivemethodforsimultaneousdeterminationofthequaternaryammoniumpesticideschlormequatandmepiquatinpearsandpotatoesbymodifiedQuEChERS-highperformanceliquidchromatography-tandemmassspectrometry.RSCAdv,2015,5,5895-903 LiMa,JunHe,XiaoqingZhang,YueCui,JieyingGao,XiufangTangandMinDing*.Determinationoftotal,free,andreducedhomocysteineandrelatedaminothiolsinuremicpatientsundergoinghemodialysisbyprecolumnderivatizationHPLCwith?uorescencedetection.RSCAdv,2014,4,58412–6 MingZuo,JieyingGao,XiaoqingZhang,YueCui,ZimianFan,MinDing*.Capillaryelectrophoresiswithelectrochemiluminescencedetectionforthesimultaneousdeterminationofcisatracuriumbesylateanditsdegradationproductsinpharmaceuticalpreparations.J.Sep.Sci.2015,38,2332–2339 MinglinOu,XiaoqingZhang,YongDai,JieyingGao,MingsongZhu,XiangchunYang,YuchaoLi,TingYang,MinDing*.Identi?cationofpotentialmicroRNA–targetpairsassociatedwithosteopetrosisbydeepsequencing,iTRAQproteomicsandbioinformatics.EuropeanJournalofHumanGenetics,22:625–632,2014 JieyingGao,TingYang,MaoYe,XiaoqingZhang,GangTian,QiannaZhen,MinDing?,High-performanceliquidchromatographyassaywithprogrammedflowelutionforcisatracuriuminhumanplasma:Applicationtopharmacokineticsininfantsandchildren,JournalofChromatographyB,955–956:58–63,2014 XiaoqingZhang,WenpingDeng,YannaBan,JieyingGao,MinDing*.Ahighlysensitiveelectricallydrivenelectrochemiluminescentassayforquanti?cationofbileacidsinhumanserum.Analyst,138:5074-5080,2013 JianboChen,WenpingDeng,JunweiWang,YongShao,MinglinOu,MinDing.Primarybileacidsaspotentialbiomarkersfortheclinicalgradingofintrahepaticcholestasisofpregnancy.InternationalJournalofGynecology&Obstetrics,122:5-8,2013 唐秀芳,王箭,张晓清,高茹菲,丁敏*.高效液相色谱-程序波长紫外检测法同时测定小鼠红细胞中S-腺苷甲硫氨酸和S-腺苷同型半胱氨酸.分析化学,41(4):570-574,2013 唐秀芳,甄乾娜,樊子勉,冯成亚,丁敏*.柱前衍生高效液相色谱荧光检测法测定血浆同型半胱氨酸.色谱,30(6):613-617,2012 马莉,张名均,甄乾娜,田刚,丁敏*.HPLC—UV检测法同时测定血浆色氨酸和犬尿氨酸的方法学研究.中华检验医学杂志,34(12):1057-1061,2011 QiannaZhen,BiaoXu,LiMa,GangTian,XiufangTang,MinDing*.Simultaneousdeterminationoftryptophan,kynurenineand5-hydroxytryptaminebyHPLC:Applicationinuremicpatientsundergoinghemodialysis.ClinicalBiochemistry,44:226-230,2011 田刚,甄乾娜,班艳娜,唐秀芳,丁敏*.血清胆汁酸代谢轮廓分析在妊娠肝内胆汁淤积症诊断中的应用.重庆医科大学学报,36(5):586-588,2011 丁敏,王箭,张晓清,邓文平.酶促电化学发光法测定血清总胆汁酸.分析化学,38(12):1793-1796,2010 QiannaZhen,BiaoXu,LiMa,GangTian,XiufangTang,MinDing.Simultaneousdeterminationoftryptophan,kynurenineand5-hydroxytryptaminebyHPLC:Applicationinuremicpatientsundergoinghemodialysis.ClinicalBiochemistry,2011(44):226–230 丁敏,王箭,张晓清,邓文平.酶促电化学发光法测定血清总胆汁酸.分析化学,2010,38(12):1793~1796

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