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个人简介

Work Experience 教授:西安交通大学 生命科学与技术学院,2019年 副教授:西安交通大学 生命科学与技术学院,2017年 访问学者:日本东北大学(Tohoku University) 材料科学高等研究所,2016年 副教授:西安交通大学 理学院,2011年 博士后:美国天普大学(Temple University) 化学系, 2009年 博士后:瑞士洛桑联邦理工学院(EPFL) 化学与化工学院, 2008年 Educational Experience 博士(化学):英国华威大学(University of Warwick) 化学系, 2007年 硕士(分析化学):中国科学院长春应用化学研究所 电分析国家重点实验室, 2004年 本科(化学):西北大学 化学系基地班, 2001年

研究领域

单细胞电分析化学:单细胞光电化学显微成像分析,细胞微环境研究 即时检测技术:纸基即时电化学检测芯片技术、柔性电子材料研发

近期论文

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Y. Zhou, X. Zhou, J. J. Zhang, Y. X. Zhao, Z. Y. Ye, F. Xu, F. Li*, Confined Mechanical Microenvironment Regulated Antibiotic Resistance in 3D Biofilm Aggregates Probed by Scanning Electrochemical Microscopy, Analytical Chemistry, 2025, Accepted J. J. Zhang, Y. L. Liu, Y. X. Zhao, S. Y. Zhang, F. Xu, F. Li*, Synergetic effect of mild hypothermia and antioxidant treatment on ROS-mediated neuron injury under oxygen-glucose deprivation investigated by scanning electrochemical microscopy, Chemical Science, 2024, 15, 20177-20188. T. Zhu, Z. Y. Ye, J. J. Song, J. J. Zhang, Y. X. Zhao, F. Xu, J. Wang, X. Huang, B. Gao*, F. Li*, Effect of extracellular matrix stiffness on efficacy of Dapagliflozin for diabetic cardiomyopathy, Cardiovascular Diabetology, 2024, 23, 273. Y.X. Zhao, Z. Y. Ye, Y. L. Liu, J. J. Zhang, S. Kuermanbayi, Y. Zhou, H. Guo, F. Xu, F. Li*, Investigating the role of extracellular matrix stiffness in modulating ferroptosis process in hepatocellular carcinoma cells via scanning electrochemical microscopy, Analytical Chemistry, 2024, 96, 1102-1111 (Journal Cover) Y. L. Liu, J. J. Zhang, Y. B. Li, Y. X. Zhao, S. Kuermanbayi, J. Zhuang, H. Zhang, F. Xu*, F. Li*, Matrix stiffness-dependent microglia activation in response to inflammatory cues: in situ investigated by scanning electrochemical microscopy, Chemical Science, 2024, 15, 171-184 J.C. Niu, W.J. Liu, J.X.Z. Li, X.L. Pang, Y.L. Liu, C. Zhang, K.Y. Yue, Y.L. Zhou, F. Xu, X.G. Li*, F. Li*, Machining water through laser cutting of water in liquid pancake, Nature Communications, 2023, 14, 3853. Y. L. Zhou#, J. C. Niu#, B. Peng#, Y. Zhou, F. Li*, Liquid plasticine-based electrokinetic enrichment of proteins, ChemistryOpen, 2023, 12, e202200259. T. Zhu, J. J. Song, B. Gao, J. J. Zhang, Y. B. Li, Z. Y. Ye, Y. X. Zhao, X. G. Guo, F. Xu, F. Li*, Effect of extracellular matrix stiffness on Candesartan efficacy in anti-fibrosis and antioxidation, Antioxidants, 2023, 12(3), 679. Z. Y. Ye, Y. B. Li, Y. X. Zhao, J. J. Zhang, T. Zhu, F. Xu, F. Li*, Effect of exogenous electric stimulation on cardiac tissue function in situ monitored by scanning electrochemical microscopy, Analytical Chemistry, 2023, 95(10), 4634–4643 Y.X. Zhao, Y.B. Li, S. Kuermanbayi, Y.L. Liu, J.J. Zhang, Z.Y. Ye, H. Guo, K. Qu, F. Xu, F. Li*, In situ and quantitatively monitoring dynamic process of ferroptosis in single cancer cell by scanning electrochemical microscopy, Analytical Chemistry, 2023, 95, 3, 1940. 方天舒,牛纪成,许贝多,张悦,黎黎*, 李菲*, 眼表便携式即时检测技术与应用研究进展, 分析化学, 2022, 50(11), 1639-1660 J. J. Zhang, Y. L. Liu, Y. B. Li, T. Zhu, J. B. Qiu, F. Xu, H. Zhang, F. Li*, In situ and quantitatively imaging of heat-induced oxidative state and oxidative damage of living neurons using scanning electrochemical microscopy, Small Methods, 2022, 2200689 Y. C. Li#, Y. N. Liu#, B. Peng#, X. Y. Li, T. S. Fang, S. Liu, J. C. Liu, B. Li, F. Li*, Stretchable, conductive, breathable and moisture-sensitive e-skin based on CNTs/graphene/GelMA mat for wound monitoring, Biomaterials Advances, 2022, 143, 213172 M. L. He#, L. Feng#, Y. Chen#, B. Gao#, Y. W. Du, L. Zhou, F. Li*, H. B. Liu*, Polydatin attenuates tubulointerstitial fibrosis in diabetic kidney disease by inhibiting YAP expression and nuclear translocation, Frontiers in Physiology, 2022, DOI: 10.3389/fphys.2022.927794 Y. Zhou, J. J. Zhang, Y. X. Zhao, Y. L. Liu, F. Li*, Bacterial Biofilm Probed by Scanning Electrochemical Microscopy: A Review, ChemElectroChem, 2022, 9, e202200470 S. Kuermanbayi#, Y. W. Yang#, Y. X. Zhao, Y. B. Li, L. Wang, J. Yang, Y. Zhou, F. Xu*, F. Li*, In situ monitoring of functional activity of extracellular matrix stiffness-dependent multidrug resistance protein 1 using scanning electrochemical microscopy, Chemical Science, 2022, 13, 10349–10360 Y. B. Li, Z. Y. Ye, J. J. Zhang, Y. X. Zhao, T. Zhu, J. J. Song, F. Xu, F. Li*, In situ and quantitative monitoring of cardiac tissues using programmable scanning electrochemical microscopy, Analytical Chemistry, 2022, 94, 29, 10515–10523 Y. L. Liu#, Y. X. Zhao#, Y. B. Li, Z. Y. Ye, J. J. Zhang, Y. Zhou, T. Y. Gao, F. Li*, Recent advances of nanoelectrodes for single-cell electroanalysis: from extracellular, intercellular to intracellular, Journal of Analysis and Testing,, 2022, 6, 178–192 Z. D. Li, S. Wu, J. C. Ji, Y. M. Bai, P. P. Jia, Y. Gong, S. S. Feng, F. Li*, Ball Pen Writing without Ink: A Truly Simple and Accessible Method for Sensitivity Enhancement in Lateral Flow Assays, RSC Advances, 2022, 12, 2068-2073. B. Li*, Y. H. Wu, Y. Sun, W. T. Ma, L. Jiang, Z. C. Yang, F. Li, G. M. Chen*, Patterning coexisted micro/nano structures for consequential camouflage via mechanical constraint harnessed surface instability, Applied Physics Letters, 2021, 119, 264103. L. Cao, X. J. Guo, P. Mao, Y. L. Ren, Z. D. Li, M. L. You, J. Hu, M. Tian, C. Y. Yao, F. Li, F. Xu*, A Portable Digital Loop-Mediated Isothermal Amplification Platform Based on Microgel Array and Hand-Held Reader, ACS Sensors, 2021, 6(10), 3564–3574. R. Y. He#, H. Liu#, T. S. Fang, Y. Niu, H. Q. Zhang, F. Han, B. Gao, F. Li*, F. Xu*, A Colorimetric Dermal Tattoo Biosensor Fabricated by Microneedle Patch for Multiplexed Detection of Health-related Biomarkers, Advanced Science, 2021, 2103030. J. X. Lang#, Y. B. Li#, Z. Y. Ye, Y. W. Yang, F. Xu, G. Y. Huang, J. J. Zhang, F. Li*, Investigating the effect of substrate stiffness on redox state of cardiac fibroblasts using scanning electrochemical microscopy, Analytical Chemistry, 2021, 93(14), 5797–5804. Y. B. H. Jiao, J. Zhuang*, Z. D. Li, L. Cao, F. Xu, F. Li, Q. Q. Zheng, Z. J. Gao, Analysis and improvement of positioning reliability and accuracy of theta pipette configuration for scanning ion conductance microscopy, Ultramicroscopy, 2021, 224, 113240. W. H. He#, M. L. You#, Z. D. Li, L. Cao, F. Xu, F. Li*, A. Li*, Upconversion nanoparticles-based lateral flow immunoassay for point-of-care diagnosis of periodontitis, Sensors and Actuators: B. Chemical, 2021, 334, 129673 J. C. Niu, Z. H. Bao, Z. N. Wei, J. X. Z. Li, B. Gao, X. F. Jiang*, F. Li*, A Three-Dimensional Paper-Based Isoelectric Focusing Device for Direct Analysis of Proteins in Physiological Samples, Analytical Chemistry, 2021, 93(8), 3959-3967 (Journal Cover) 李亚北, 叶朝阳, 刘禹霖, 赵宇翔, 翟阳, 朱彤, 徐峰, 李菲*, 扫描电化学显微镜在生物医学领域的应用研究进展, 中国科学:化学, 2021, 51(3), 337-358. R. H. Tang, L. N. Liu, M. Li, X. Yao, Y. W. Yang, S. F. Zhang*, F. Li*, Transparent Microcrystalline Cellulose/Polyvinyl Alcohol Paper as New Platform for 3D Cell Culture, Analytical Chemistry, 2020, 92(20), 14219–14227. X. J. Guo, Y. B. Li, Y. C. Li, Z. Y. Ye, J. J. Zhang, T. Zhu, F. Li*, An L012@PAni-PAAm hydrogel composite based-electrochemiluminescence biosensor for in situ detection of H2O2 released from cardiomyocytes, Electrochemica Acta, 2020, 354, 136763. J. J. Zhang#, T. Zhu#, J. X. Lang, W. X. Fu, F. Li*, Recent advances of scanning electrochemical microscopy and scanning ion conductance microscopy for single cell analysis, Current Opinion in Electrochemistry, 2020, 22, 178-185. M. Wang#, Y. W. Yang#, L. C. Han#, S. Han, N. Liu, F. Xu. Li*, F. Li*, Effect of three-dimensional ECM stiffness on cancer cell migration through regulating cell volume homeostasis, Biochemical and Biophysical Research Communications, 2020, 528, 459-465. J. C. Niu, H. X. Shi, H. G. Wei, B. Gao, J. Li, F. Xu, X. G. Li*, F. Li*, Liquid Plasticine Integrated with Isoelectric Focusing for Miniaturized Protein Analysis, Analytical Chemistry, 2020,2, 9048-9056(Journal Cover) Y. C. Li, C. R. Zheng, S. Liu, L. Huang, T. S. Fang, J. Li, F. Xu, F. Li*, A Smart Glove Integrated with Tunable MWNTs/PDMS Fibers Made of One-Step Extrusion Method for Finger Dexterity, Gesture and Temperature Recognition, ACS Applied Materials & Interfaces, 2020, 12, 21, 23764–23773. Y. B. Li#, J. X. Lang#, Z. Y. Ye, M. Wang, Y. W. Yang, X. J. Guo, J. Zhuang, J. J. Zhang, F. Xu, F. Li*, Effect of substrate stiffness on redox state of single cardiomyocyte: a scanning electrochemical microscopy study, Analytical Chemistry, 2020, 92, 7, 4771-4779 R. Y. He, Y. Niu, Z.D. Li, A. Li, H. Y. Yang, F. Xu, F. Li*, A Hydrogel Microneedle Patch for Point-of-Care Testing Based on Skin Interstitial Fluid, Advanced Healthcare Materials, 2020, 9, 1901201. M. Wang, Y. W. Yang, F. Xu, F. Li*, Cell mechanical microenvironment for cell volume regulation, Journal of Cellular Physiology, 2020, 235, 4070–4081. F. Li#, M. L. You#, S. X. Li#, J. Hu, Y. Gong, C. Liu, H. Y. Yang*, F. Xu*, Paper-based point-of-care immunoassays: recent advances and emerging trends, Biotechnology Advances, 2020, 39, 107442. H. Liu, M. X. Li, S. B. Liu, P. P. Jia, X. J. Guo, S. S. Feng, T. J. Lu, H. Y. Yang,, F. Li*, F. Xu*, Spatially Modulated Stiffness on Hydrogel for Soft and Stretchable Integrated Electronics, Material Horizons, 2020, 7, 203.

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