McLuckey, Scott A. - Purdue University - Department of Chemistry

个人简介

John A. Leighty Distinguished Professor, Purdue University, June, 2008 - Professor of Chemistry, Purdue University, January, 2000. Adjunct R&D Participant, Oak Ridge National Laboratory, 2000-2008. Section Head, Analytical Spectroscopy, Chemical and Analytical Sciences Division, Oak Ridge National Laboratory, January, 1992-December, 1999. Acting Group Leader, Organic and Biological Mass Spectrometry Group, Oak Ridge National Laboratory, July, 1992-March, 1994, January, 1999-December, 1999. Task Leader, Organic Mass Spectrometry Group, Oak Ridge National Laboratory, November, 1988-January, 1992. Research Staff, Analytical Chemistry Division, Oak Ridge National Laboratory, December, 1983-November, 1988. Visiting Scientist, FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands, November, 1982-November, 1983. Graduate Research Assistant, Department of Chemistry, Purdue University, May, 1980-October, 1982.

研究领域

Research in this laboratory is devoted to understanding the chemistry of gaseous macro-ions. These ions are typically derived via electrospray of proteins, oligonucleotides, synthetic polymers, and clusters. The major tools for studying the ions are various forms of mass spectrometry with particular emphasis on the quadrupole ion trap mass spectrometer. The goals are to understand the underlying phenomena that direct the dissociation of high mass ions and the reactions of these ions with neutral molecules and with ions of opposite charge. In realizing these goals, new approaches to the analysis of macro-molecules are enabled. A significant degree of effort is, therefore, also expended towards the exploitation of gaseous macro-ion chemistry in chemical analysis. This effort involves both the development of novel experimental procedures as well as the construction of novel instrumentation. Current areas of interest are the rapid identification of proteins in complex mixtures, sequencing DNA, and structural analysis of dendritic polymers.

近期论文

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J. C. Dean, N. L. Burke, J. R. Hopkins, J. G. Redwine, P. V. Ramachandran, S. A. McLuckey, T. S. Zwier, J. Phys. Chem., ASAP. UV Photofragmentation and IR Spectroscopy of Cold, G-Type beta-O-4 and beta–beta Dilignol–Alkali Metal Complexes: Structure and Linkage-Dependent Photofragmentation J. D. Gilbert, B. M. Prentice, S.A. McLuckey, J. Am. Soc. Mass Spectrom., ASAP. Ion/Ion Reactions with "Onium" Reagents: An Approach for the Gas-phase Transfer of Organic Cations to Multiply-Charged Anions J. D. Gilbert, C. M. Fisher, J. Bu. , B. M. Prentice, J. G. Redwine, S.A. McLuckey, J. Mass Spectrom. 50 (2015), 418-426. Strategies for Generating Peptide Radical Cations via Ion/Ion Reactions C. A. Luongo, J. Bu., N. L. Burke, J. D. Gilbert, B. M. Prentice, S. Cumming, C. A. Reed, S.A. McLuckey, J. Am. Soc. Mass Spectrom., 26 (2015), 404-414. Selective Removal of Alkali Metal Cations from Multiply-Charged Ions via Gas-Phase Ion/Ion Reactions Using Weakly Coordinating Anions J. C. DeMuth, S.A. McLuckey, Anal. Chem., 87 (2015) 1210-1218. Electrospray Droplet Exposure to Organic Vapors: Metal Ion Removal from Proteins and Protein Complexes R.T. Hilger, E.T. Dziekonski, R.E. Santini, S.A. McLuckey, Int. J. Mass Spectrom., In Press. Injecting Electrospray Ions Into a Fourier Transform Electrostatic Linear Ion Trap Z. Peng, W.M. McGee, J. Bu, N.Z. Barefoot, S.A. McLuckey, J. Am. Soc. Mass Spectrom., 26 (2015) 174-180. Gas Phase Reactivity of Carboxylates with N-Hydroxysuccinimide Esters R.T. Hilger, R.E. Santini, C.A. Luongo, B.M. Prentice, S.A. McLuckey, Int. J. Mass Spectrom., In Press. A Method for Isolating Ions in Quadrupole Ion Traps Using an Excitation Waveform Generated by Frequency Modulation and Mixing N.L. Burke, J.G. Redwine, J.C. Dean, S.A. McLuckey, T.S. Zwier, Int. J. Mass Spectrom., In Press. UV and IR Spectroscopy of Cold Protonated Leucine Enkephalin R.T. Hilger, R.E. Santini, S.A. McLuckey, Anal. Chem., 86 (2014) 8822-8828. Tandem Mass Spectrometry in an Electrostatic Linear Ion Trap Modified for Surface-Induced Dissociation A. Kharlamova, C.M. Fisher, S.A. McLuckey, J. Mass Spectrom., 49 (2014) 437-444. Hydrogen/Deuterium Exchange in Parallel with Acid/Base Induced Protein Conformational Change in Electrospray Droplets C.M. Fisher, A. Kharlamova, S.A. McLuckey, Anal. Chem., 86 (2014) 4581-4588. Affecting Protein Charge State Distributions in Nano-Electrospray Ionization via In-Spray Solution Mixing Using Theta Capillaries A.L. Pilo, S.A. McLuckey, J. Am. Soc. Mass Spectrom. 25 (2014) 1049-1057. Oxidation of Methionine Residues in Polypeptide Ions Via Gas-Phase Ion/Ion Chemistry R.T. Hilger, R.E. Santini, S.A. McLuckey, Int. J. Mass Spectrom. 362 (2014) 1-8. Square Wave Modulation of a Mirror Lens for Ion Isolation in a Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometer W.M. McGee, S.A. McLuckey, Proc. Nat. Acad. Sci. USA, 111 (2014) 1288-1292. Efficient and Directed Peptide Bond Formation in the Gas Phase via Ion/Ion Reactions I.K. Webb, Y. Gao, F.A. Londry, S.A. McLuckey, J. Mass Spectrom., 48 (2013) 1059-1065. Trapping Mode Dipolar DC Collisional Activation in the RF-Only Ion Guide of a Linear Ion Trap/Time-of-Flight Instrument for Gaseous Bio-Ion Declustering R.T. Hilger, P.J. Wyss, R.E. Santini, S.A. McLuckey, Anal. Chem., 85 (2013) 8075-8079. Absorption Mode Fourier Transform Electrostatic Linear Ion Trap Mass Spectrometry W.M. McGee, S.A. McLuckey, J. Mass Spectrom., 48 (2013) 856-861. The Ornithine Effect in Peptide Cation Dissociation B.M. Prentice, W.M. McGee, J.R. Stutzman, S.A. McLuckey, Int. J. Mass Spectrom., 354-355 (2013) 211-218. Strategies for the Gas Phase Modification of Cationized Arginine via Ion/Ion Reactions W.M. McGee, S.A. McLuckey, Int. J. Mass Spectrom., 354-355 (2013) 181-187. Gas Phase Dissociation Behavior of Acyl-Arginine Peptides