个人简介
学习经历
2004年9月-2009年8月:中国科学院大连化学物理研究所硕博连读,获得工学博士学位;
2000年9月-2004年7月:辽宁大学生物技术专业,获得理学学士学位。
工作经历
2019年9月-至 今 大连民族大学 ,生命科学学院,教授;
2015年11月-2019年8月:大连海洋大学,海洋生物与生物技术实验室副主任,研究员;
2011年4月-2015年10月:中国科学院大连化学物理研究所生物技术部,副研究员;
2009年10月-2011年3月:日本东北药科大学分子生物膜研究所,博士后
研究领域
立足于天然功能糖链的发现及开发利用、糖基化修饰参与细胞生理调控、碳水化合物动物营养与免疫调节三方面基础理论研究,结合分子生物学、细胞生物学技术和活体动物实验,重点研究糖链识别、糖链代谢、糖链修饰对生命机体免疫、生长、抗病的协同作用机制。同时着眼于相关技术和产品转化,研发糖类免疫增强剂和生物制品
近期论文
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1)Qingsong Xu, Chen Qu, Jin Wan, et al. Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome. RSC Advances (2018) 8, 13266-13273. (SCI收录 IF= 3.049)
2)Qingsong Xu, Wenjing Wang, Chen Qu, et al. Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure. Carbohydrate Polymers (2017) 170, 241-246. (SCI收录IF= 6.044)
3)Qingsong Xu, Meisi Liu, Qishun Liu, et al. The inhibition of LPS-induced inflammation in RAW264.7 macrophages via the PI3K/Akt pathway by highly N-acetylated chitooligosaccharide. Carbohydrate Polymers (2017) 174,1138-1143. (SCI收录IF= 6.044)
4)Qingsong Xu, Wenjing Wang, Wen Yang et al. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/mitogen-activated protein kinase pathway. International Journal of Biological Macromolecules (2017) 98, 502-505. (SCI收录IF= 4.784)
5)Qingsong Xu, Xueming Niu, Wenjing Wang, et al. Specific N-glycan alterations are coupled in EMT induced by different density cultivation of MCF 10A epithelial cells. Glycoconjugate journal (2017) 34, 219-227. (SCI收录IF= 2.926)
6)Qingsong Xu, Chen Qu, Wenjing Wang, et al. Specific N-glycan alterations are coupled in epithelial–mesenchymal transition induced by EGF in GE11 epithelial cells. Cell Biology International (2017) 41, 124-133. (SCI收录IF= 2.127)
7)Qingsong Xu, Tomoya Isaji, Yingying Lu, et al. Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by TGF-β1 in human and mouse epithelial cell lines. Journal of Biological Chemistry, (2012), 11;287(20):16563-74. (SCI收录IF= 4.106)
8)Qingsong Xu, Ryota Akama, Tomoya Isaji, et al. Wnt/{beta}-catenin Signaling Down-regulates N-Acetylglucosaminyltransferase III Expression: The implication of two mutually exclusive pathways for regulation. Journal of Biological Chemistry, (2011), 11;286(6):4310-8. (SCI收录IF= 4.106)
9)Qingsong Xu, Pan Ma, Weiting Yu, et al. Chitooligosaccharides protect human embryonic hepatocytes against oxidative stress induced by hydrogen peroxide. Marine Biotechnology, (2010) 12:292–298. (SCI收录 IF= 2.798)
10)Qingsong Xu, Jiangli Dou, Peng Wei, et al. Chitooligosaccharides induce apoptosis of human hepatocellular carcinoma cells via up-regulation of Bax. Carbohydrate Polymers (2008) 71: 509–514. (SCI收录IF= 6.044)
11)Qingsong Xu, Jiangli Dou, Xuefang Bai, et al. Hepatoprotective activity of chitooligosaccharides against ethanol induced toxicity in experiment rats. Journal of Biotechnology 136S (2008) S581. (SCI收录 IF= 3.163)
12)Jin Wan, Fei Jiang, Qingsong Xu,* et al. New insights into the role of chitosan oligosaccharide in enhancing growth performance, antioxidant capacity, immunity and intestinal development of weaned pigs. RSC Advances (2017) 7, 9669–9679. (SCI收录 IF= 3.049) (并列通讯作者)
13)Jin Wan, Kaiyun Yang, Qingsong Xu,* et al. Dietary chitosan oligosaccharide supplementation improves foetal survival and reproductive performance in multiparous sows. RSC Advances, (2016), 6, 70715–70722 (SCI收录 IF= 3.049) (并列通讯作者)
14)Jin Wan, Fei Jiang, Qingsong Xu,* et al. Alginic acid oligosaccharide accelerates weaned pig growth through regulating antioxidant capacity, immunity and intestinal development. RSC Advances, (2016) 6, 87026–87035. (SCI收录 IF= 3.049) (并列通讯作者)