王春江 - 武汉大学 - 化学与分子科学学院

个人简介

1997─2000: M.S., Department of Chemistry, Central South University, China (Supervisor: Professor Younian Liu) 2000─2003: Ph.D., Shanghai Institute of Organic Chemistry (SIOC) (Supervisor: Professor Min Shi) 2003─2006: Postdoctoral Fellow, Department of Chemistry, Penn State University (Supervisor: Professor Xumu Zhang) 2006─2008: Associate Professor, College of Chemistry and Molecular Sciences, Wuhan University 2008─present: Professor, College of Chemistry and Molecular Sciences, Wuhan University

研究领域

Our current research interests focus on asymmetric catalysis with efforts to develop novel and practical methodologies for the efficient construction of biologically active and synthetically useful molecules, including heterocyclic compounds and nonproteinogenic α-amino acids (α-AAs), etc. Catalytic Asymmetric 1,3-Dipolar Cycloaddition Catalytic Asymmetric Diels-Alder/Formal [4+2]-Cycloaddition Design and Synthetic Application of Bifunctional Organocatalysts

近期论文

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Iridium-Catalyzed Asymmetric Cascade Allylation/[1,4]-Phospha-Brook Rearrangement Reaction Zhi-Yuan Yi, Hui Xu, Xin Chang, Yanfeng Dang*, Xiu-Qin Dong* and Chun-Jiang Wang*ACS Catal., 2024, 14, 14058-14068 DOI: 10.1021/acscatal.4c04078 Copper/ruthenium relay catalysis enables 1,6-double chiral inductions with stereodivergence Hao-Ran Yang, Xiang Cheng, Xin Chang, Zuo-Fei Wang, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Sci., 2024, 15, 10135-10145 DOI: 10.1039/D4SC01804D Iridium-catalyzed asymmetric cascade dearomative allylation/acyl transfer rearrangement: access to chiral N-substituted 2-pyridones Wei-Yi Wang, Zhi-Yuan Yi, Zuo-Fei Wang, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Commun., 2024, 60, 5086-5089 DOI: 10.1039/D4CC00944D Visible-light-enabled stereoselective synthesis of functionalized cyclohexylamine derivatives via [4 + 2] cycloadditions Yi-Nan Lu, Chao Che, Guangjin Zhen, Xin Chang, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Sci., 2024, 15, 6507-6514 DOI: 10.1039/D4SC00667D Challenging Task of Ni-Catalyzed Highly Regio-/Enantioselective Semihydrogenation of Racemic Tetrasubstituted Allenes via a Kinetic Resolution Process Gang Liu, Xuanliang Yang, Pei Gu, Minyan Wang*, Xumu Zhang*, and Xiu-Qin Dong*J. Am. Chem. Soc., 2024, 146, 7419-7430 DOI: 10.1021/jacs.3c12597 Synergistic Dual Catalysis in Stereodivergent Synthesis Liang Wei, Cong Fu, Zuo-Fei Wang, Hai-Yan Tao*, and Chun-Jiang Wang*ACS Catal., 2024, 14, 3812-3844 DOI: 10.1021/acscatal.3c06267 Modular access to chiral bridged piperidine-γ-butyrolactones via catalytic asymmetric allylation/aza-Prins cyclization/lactonization sequences Cong Fu, Ling He, Hui Xu, Zongpeng Zhang, Xin Chang, Yanfeng Dang*, Xiu-Qin Dong* and Chun-Jiang Wang*Nat. Commun., 2024, 15, 127 DOI: 10.1038/s41467-023-44336-2 Copper/Ruthenium Relay Catalysis for Stereodivergent Access to δ-Hydroxy α-Amino Acids and Small Peptides Dr. Cong Fu, Ling He, Dr. Xin Chang, Xiang Cheng, Zuo-Fei Wang, Dr. Zongpeng Zhang, Prof. Vladimir A. Larionov, Prof. Xiu-Qin Dong, Prof. Chun-Jiang Wang*Angew. Chem. Int. Ed., 2024, e202315325 DOI: 10.1002/anie.202315325 Stereodivergent synthesis of α-fluoro α-azaaryl γ-butyrolactones via cooperative copper and iridium catalysis Kui Tian, Xin Chang, Lu Xiao, Xiu-Qin Dong* and Chun-Jiang Wang*Fundam. Res., 2024, 4, 77-85 DOI: 10.1016/j.fmre.2022.07.008 Organocatalytic atroposelective synthesis of axially chiral N,N′-pyrrolylindoles via de novo indole formation Cong-Shuai Wang, Qi Xiong, Hui Xu, Hao-Ran Yang, Yanfeng Dang*, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Sci., 2023, 14, 12091-12097 DOI: 10.1039/D3SC03686C Copper-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with β-trifluoromethyl-substituted alkenyl heteroarenes Xiang Cheng, Xin Chang, Yuhong Yang, Zongpeng Zhang, Jing Li, Yipu Li, Wenxiao Zhao, Lung Wa Chung*, Huailong Teng*, Xiu-Qin Dong* and Chun-Jiang Wang*Sci. China Chem., 2023, 66, 3193-3204 DOI: 10.1007/s11426-023-1683-9 Stereodivergent synthesis of enantioenriched unnatural α-amino acids enabled by synergistic dual metal catalysis Liang Wei, Xin Chang, Zongpeng Zhang, Zuo-Fei Wang, Chun-Jiang Wang*Chinese Sci. Bull., 2023, 68, 3956-3968 DOI: 10.1360/TB-2023-0178 Electron-rich benzofulvenes as effective dipolarophiles in copper(i)-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides Xin Chang, Xue-Tao Liu, Fangfang Li, Yuhong Yang, Lung Wa Chung* and Chun-Jiang Wang*Chem. Sci., 2023, 14, 5460-5469 DOI: 10.1039/D3SC00435J Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysis Bing-Ke Zhu, Hui Xu, Lu Xiao, Xin Chang, Liang Wei, Huailong Teng, Yanfeng Dang*, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Sci., 2023, 14, 4134-4142 DOI: 10.1039/D3SC00118K Enantio- and Diastereoselective De Novo Synthesis of 3-Substituted Proline Derivatives via Cooperative Photoredox/Brønsted Acid Catalysis and Epimerization Chao Che, Yi-Nan Lu, and Chun-Jiang Wang*J. Am. Chem. Soc., 2023, 145, 2779-2786 DOI: 10.1021/jacs.2c12995 Asymmetric transformations enabled by synergistic dual transition-metal catalysis Liang Wei, Chun-Jiang Wang*Chem Catal., 2023, 3, 100455 DOI: 10.1016/j.checat.2022.10.031 Iridium-Catalyzed Asymmetric Cascade Allylation/Retro-Claisen Reaction Zhi-Yuan Yi, Lu Xiao, Xin Chang, Xiu-Qin Dong* and Chun-Jiang Wang*J. Am. Chem. Soc., 2022, 144, 20025-20034 DOI: 10.1021/jacs.2c08811 Cooperative Catalyst-Enabled Regio- and Stereodivergent Synthesis of α-Quaternary α-Amino Acids via Asymmetric Allylic Alkylation of Aldimine Esters with Racemic Allylic Alcohols Lu Xiao, Xin Chang, Hui Xu, Qi Xiong, Prof. Dr. Yanfeng Dang* and Prof. Dr. Chun-Jiang Wang*Angew. Chem. Int. Ed., 2022, e202212948 DOI: 10.1002/anie.202212948 Base-promoted cascade β-F-elimination/electrocyclization/Diels–Alder/retro-Diels–Alder reaction: efficient access to δ-carboline derivatives Xi-Shang Sun, Xin-Yu Diao, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Sci., 2022, 13, 10448-10454 DOI: 10.1039/D2SC03166C Stereodivergent Synthesis of Enantioenriched α-Deuterated α-Amino Acids via Cascade Cu(I)-Catalyzed H–D Exchange and Dual Cu- and Ir-Catalyzed Allylation Cong Fu, Xin Chang, Lu Xiao, and Chun-Jiang Wang*Org. Lett., 2022, 24, 5562-5567 DOI: 10.1021/acs.orglett.2c02102 Ir-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope Investigations and Mechanistic Studies Gongyi Liu, Lini Zheng, Kui Tian, Haifeng Wang, Lung Wa Chung, Xumu Zhang* and Xiu-Qin Dong*CCS Chem., 2022, Just Published. DOI: 10.31635/ccschem.022.202101643 Copper-catalyzed asymmetric propargylic substitution with salicylaldehyde-derived imine esters Ruo-Qing Wang, Chong Shen, Xiang Cheng, Xiu-Qin Dong* and Chun-Jiang Wang*Chem. Commun., 2022, 58, 8552-8555 DOI: 10.1039/D2CC01695H Stereodivergent Construction of 1,4-Nonadjacent Stereocenters via Hydroalkylation of Racemic Allylic Alcohols Enabled by Copper/Ruthenium Relay Catalysis Xin Chang, Xiang Cheng, Xue-Tao Liu, Cong Fu, Wei-Yi Wang, Chun-Jiang Wang* Angew. Chem. Int. Ed., 2022, e202206517 DOI: 10.1002/anie.202206517 Design, Synthesis and Application of Multifunctional Chiral Aminophosphine Catalyst for Asymmetric Intermolecular Cross Rauhut-Currier Reaction Wu-Wei Dong, Kui Tian, Xiu-Qin Dong,* and Chun-Jiang Wang* Chin. J. Chem., 2022, 40, 2061-2066 DOI: 10.1002/cjoc.202200205 Stereodivergent synthesis of enantioenriched azepino[3,4,5-cd]-indoles via cooperative Cu/Ir-catalyzed asymmetric allylic alkylation and intramolecular Friedel–Crafts reaction Lu Xiao, Bo Li, Fan Xiao, Cong Fu, Liang Wei, Yanfeng Dang*, Xiu-Qin Dong* and Chun-Jiang Wang* Chem. Sci., 2022, 13, 4801-4812 DOI: 10.1039/D1SC07271D Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives Xin Chang, Xiang Cheng and Chun-Jiang Wang* Chem. Sci., 2022, 13, 4041-4049 DOI: 10.1039/D2SC00826B Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides Xiao Xu, Longzhu Bao, Lu Ran, Zhenyan Yang, Dingce Yan, Chun-Jiang Wang* and Huailong Teng* Chem. Sci., 2022, 13, 1398-1407 DOI: 10.1039/D1SC04595D Asymmetric Synthesis of Chiral Aza-macrodiolides via Iridium-Catalyzed Cascade Allylation/Macrolactonization Qi Xiong, Lu Xiao, Xiu-Qin Dong*, and Chun-Jiang Wang* Org. Lett., 2022, 24, 2579-2584 DOI: 10.1021/acs.orglett.2c00942 Iridium-catalyzed asymmetric double allylic alkylation of azlactone: efficient access to chiral α-amino acid derivatives Xiang Cheng, Chong Shen, Xiu-Qin Dong* and Chun-Jiang Wang* Chem. Commun., 2022, 58, 3142-3145 DOI: 10.1039/D2CC00328G Catalytic Asymmetric Benzylation of Azomethine Ylides Enabled by Synergistic Lewis Acid/Palladium Catalysis Xin Chang, Jing-Di Ran, Xue-Tao Liu, and Chun-Jiang Wang* Org. Lett., 2022, 24, 2573-2578 DOI: 10.1021/acs.orglett.2c00865 Stereodivergent Synthesis of Carbocyclic Quaternary α-Amino Acid Derivatives Containing Two Contiguous Stereocenters Cong Fu, Qi Xiong, Lu Xiao, Ling He, Tian Bai, Zongpeng Zhang, Xiu-Qin Dong* and Chun-Jiang Wang* Chin. J. Chem., 2022, 40, 1059-1065 DOI: 10.1002/cjoc.202100824 Stereodivergent synthesis via iridium-catalyzed asymmetric double allylic alkylation of cyanoacetate Chong Shen, Xiang Cheng, Liang Wei, Ruo-Qing Wang and Chun-Jiang Wang* Chem. Sci., 2021, 12, 15882-15891 DOI: 10.1039/D1SC06115A Stereodivergent Synthesis of Enantioenriched γ-Butyrolactones Bearing Two Vicinal Stereocenters Enabled by Synergistic Copper and Iridium Catalysis Lu Xiao, Dr. Liang Wei, Prof. Dr. Chun-Jiang Wang* Angew. Chem. Int. Ed., 2021, 60, 24930-24940 DOI: 10.1002/anie.202107418 Asymmetric Synthesis of Axially Chiral Naphthyl-C3-indoles via a Palladium-Catalyzed Cacchi Reaction Cong-Shuai Wang, Liang Wei, Cong Fu, Xin-Heng Wang, and Chun-Jiang Wang* Org. Lett., 2021, 23, 7401-7406 DOI: 10.1021/acs.orglett.1c02574 Recent advances in catalytic asymmetric aza-Cope rearrangement Liang Wei and Chun-Jiang Wang* Chem. Commun., 2021, 57, 10469-10483 DOI: 10.1039/D1CC04387K Palladium catalyzed cascade umpolung allylation/acetalation for the construction of quaternary 3-amino oxindoles Xi-Shang Sun, Xin Chang, Li-Min Shi, Zuo-Fei Wang, Liang Wei* and Chun-Jiang Wang* Chem. Commun., 2021, 57, 7958-7961 DOI: 10.1039/D1CC03075B Diastereoselective synthesis of functionalized tetrahydropyridazines containing indole scaffolds via an inverse-electron-demand aza-Diels–Alder reaction Taotao Chen, Chao Che, Zhefei Guo, Xiu-Qin Dong* and Chun-Jiang Wang* Org. Chem. Front., 2021, 8, 4392-4398 DOI: 10.1039/D1QO00623A Cu-catalyzed endo-selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethenesulfonyl fluorides: Efficient access to chiral pyrrolidine-3-sulfonyl fluorides Yi-Nan Li, Xin Chang, Qi Xiong, Xiu-Qin Dong* and Chun-Jiang Wang* Chinese Chemical Letters, 2021, 32, 4029-4032 DOI: 10.1016/j.cclet.2021.05.063 Synergistic Cu/Pd-catalyzed asymmetric allylation: a facile access to α-quaternary cysteine derivatives Hui-Min Wu, Zongpeng Zhang, Liang Wei*, Xiu-Qin Dong* and Chun-Jiang Wang* Chem. Commun., 2021, 57, 6538-6541 DOI: 10.1039/D1CC01754C Palladium-Catalyzed Asymmetric Allylic Alkylation/α-Iminol Rearrangement: A Facile Access to 2-Spirocyclic-Indoline Derivatives Xin Chang, Chao Che, Zuo-Fei Wang and Chun-Jiang Wang* CCS Chem., 2021, 3, 1484-1498 DOI: 10.31635/ccschem.021.202100875 β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight Xin Chang, Yuhong Yang, Chong Shen, Kun-Shan Xue, Zuo-Fei Wang, Hengjiang Cong, Hai-Yan Tao, Lung Wa Chung*, and Chun-Jiang Wang* J. Am. Chem. Soc., 2021, 143, 3519-3535 DOI: 10.1021/jacs.0c12911 Visible‐Light‐Enabled Enantioconvergent Synthesis of α‐Amino Acid Derivatives via Synergistic Brønsted Acid/Photoredox Catalysis Chao Che, Yi‐Nan Li, Xiang Cheng, Yi‐Nan Lu, Prof. Dr. Chun‐Jiang Wang* Angew. Chem. Int. Ed., 2021, 60, 4698-4704 DOI: 10.1002/anie.202012909 Synergistic Catalysis with Azomethine Ylides Liang Wei, Chun-Jiang Wang* Chin. J. Chem., 2021, 39, 15-24 DOI: 10.1002/cjoc.202000380