雷爱文 - 武汉大学 - 高等研究院

个人简介

雷爱文 Prof. Aiwen Lei Editorial Advisory Board Member of Chemical Reviews International Advisory Board Member of ChemSusChem Editorial Board Member of Chemistry – An Asian Journal Editorial Board Member of Chinese Chemical Letters Editorial Advisory Board Member of Current Organocatalysis Education ·Ph. D., Organic Chemistry, July, 2000, Shanghai Institute of Organic Chemistry, Chinese Academy of Science (CAS), China, Supervisor - Prof. Xiyan Lu ·B.S., Chemistry Education, July, 1995, Huaibei Normal University, Huaibei, Anhui Province, P. R. China Research Interest ·Developing highly selective and efficient transition-metal-catalyzed C-C, and C-heteroatom bond formation in syntheses, e.g. oxidative coupling reactions, C-H bond functionalization ·Small molecule (such as CO, O2, N2O, H2O2, NH3, ClO2, etc.) activation with an emphasis on applying such molecules in efficient synthetic methods ·Mechanistic studies including kinetic and active intermediate studies Research Experience ·2014.10-now, Vice director of the Institute for Advanced Studies (IAS),Wuhan University ·2005.3 -now, Professor of Wuhan University ·2003.8 -2005.3, Research Associate, Department of Chemistry, Stanford University, US, with Professor James, P. Collman ·2000.8-2003.8, Postdoctoral Fellow, Department of Chemistry, the Pennsylvania State University, US, with Professor Xumu Zhang ·1995.9-2000.7, Graduate Studies, Shanghai Institute of Organic Chemistry, CAS, China (SIOC), with Professor Xiyan Lu

研究领域

Developing highly selective and efficient transition-metal-catalyzed C-C, and C-heteroatom bond formation in syntheses, e.g. oxidative coupling reactions, C-H bond functionalization Small molecule (such as CO, O2, N2O, H2O2, NH3, ClO2-, etc.) activation with an emphasis on applying such molecules in efficient synthetic methods Mechanistic studies including kinetic and active intermediate studies

近期论文

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1) Tang, Shan; Liu, Yichang; Gao, Xinlong; Wang, Pan; Huang, Pengfei; Lei, Aiwen. Multimetallic-Catalyzed Oxidative Radical Alkynylation with Termianl Alkynes: A New Strategy for C(sp3)-C(sp) Bond Formation. J. Am. Chem. Soc. 2018, DOI: 10.1021/jacs.8b02745 2)Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical Oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201800240 3)Gao, Xinlong; Wang, Pan; Zeng, Li; Tang, Shan; Lei, Aiwen. Cobalt(II)-Catalyzed Electrooxidative C-H Amination of Arenes with Alkylamines. J. Am. Chem. Soc. 2018, 140, 4195-4199 4)Tang, Shan; Wang, Siyuan; Liu, Yichang; Cong, Hengjiang; Lei, Aiwen. Electrochemical oxidative C-H Amination of Phenols: Access to Triarylamine Derivatives. Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201800240 5)Tang, Shan; Wang, Dan; Liu, Yichang; Zeng, Li; Lei, Aiwen. Cobalt-catalyzed electrooxidative C-H/N-H [4+2] annulation with ethylene or ethyne. Nature. Commun. 2018, 9, 789 6)Hu, Xia; Zhang, Guoting; Bu, Faxiang; Lei, Aiwen. Selective Oxidative [4+2] Imine/Alkene Annulation with H2 Liberation Induced by Photo-Oxidation. Angew. Chem. Int. Ed. 2018, 57, 1286-1290 7)Tian, Jun; Yang, Dali; Wen, Jianguo; Filatov, Alexander S.; Liu, Yuzi; Lei, Aiwen; Lin, Xiao-Min. A stable rhodium single-site catalyst encapsulated within dendritic mesoporous nanochannels. Nanoscale. 2018, 10, 1047-1055 8)Tang, Shan; Liu, Yichang; Lei, Aiwen. Electrochemical Oxidative Cross-coupling with Hydrogen Evolution: A Green and Sustainable Way for Bond Formation. Chem. 2018, 4, 27-45 9)Zhang Guoting; Lin, Yulin; Luo, Xu; Hu, Xia; Chen, Cong; Lei, Aiwen. Oxidative [4+2] annulation of styrenes with alkynes under external-oxidant-free conditons. Nature. Commun. 2018, 9, 1225 10) Wang, H. M.; Lu, Q. Q.; Chiang, C. W.; Luo, Y.; Zhou, J. F.; Wang, G. Y.; and Lei, A. W.; Markovnikov-Selective Radical Addition of S-Nucleophiles to Terminal Alkynes via Photoredox Process, Angew. Chem. Int. Ed. 2017, 129, 610-614 11) Yi, H.; Niu, L. B.; Song, C. L.; Li, Y. Y.; Dou, B. W.; Singh, A. K.; Lei, A. W.; Photocatalytic Dehydrogenative Cross-Coupling of Alkenes with Alcohols or Azoles without External Oxidant, Angew. Chem. Int. Ed. 2017, 56, 1120 –1124. 12) Wang, P.; Tang, S.; Huang, P. F.; Lei, A. W.; Electrocatalytic Oxidant-Free Dehydrogenative C-H/S-H Cross-Coupling, Angew. Chem. Int. Ed. 2017, 56, 3009-3013. 13) Niu, L. B.; Yi, H.; Wang, S. C.; Liu, T. Y.; Liu, J. M.; Lei, A. W.; Photo-induced oxidant-free oxidative C–H/N–H cross-coupling between arenes and azoles, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14226. 14) Yi, H.; Yang, D. L.; Xin, J.; Qi, X. T.; Lan, Y.; Deng, Y.; Pao, C. W.; Lee, J. F.; Lei, A. W.; Unravelling the hidden link of lithium halides and application in the synthesis of organocuprates, Nature Commun., 2017, 8, DOI: 10.1038/ncomms14794 15) Yi, Hong; Zhang, Guoting; Wang, Huamin; Huang, Zhiyuan; Wang, Jue; Singh, Atul K.; Lei, Aiwen, Recent Advances in Radical C-H Activation/Radical Cross-Coupling. Chem. Rev. 2017, 117, 9016 – 9085. 16) Crabtree, Robert H.; Lei, Aiwen, Introduction: C-H Activation. Chem. Rev. 2017, 117, 8481 – 8482. 17) Liu, Kun; Tang, Shan; Huang, Pengfei; Lei, Aiwen. External oxidant-free electrooxidative [3 + 2] annulation between phenol and indole derivatives. Nature Commun. 2017, 8, 775. 18) Wang, H. M.; Lu, Q. Q.; Qian, C. H.; Liu, C.; Liu, W.; Chen, K.; Lei, A. W., Solvent-Enabled Radical Selectivities: Controlled Syntheses of Sulfoxides and Sulfides. Angew. Chem. Int. Ed., 2016, 55, 1094-1097. 19) Tang, S.; Wang, P.; Li, H.; Lei, A. W., Multimetallic catalyzed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes, Nature commun. 2016, 7, 11676, DOI:10.1038/ncomms11676 20) Wu Li, Zhengli Duan, Xueye Zhang, Heng Zhang, Mengfan Wang, Ru Jiang, Hongyao Zeng, Chao Liu and Aiwen Lei, From Anilines to Isatins: Palladium-Catalyzed Oxidative C−H Double Carbonylation. Angew. Chem. Int. Ed. 2015, 54, 1893-1896. 21) Jianming Liu, Xin Zhang, Hong Yi, Chao Liu, Ren Liu, Heng Zhang, Kelei Zhuo, and Aiwen Lei. Chloroacetate-Promoted Selective Oxidation of Heterobenzylic Methylenes under Copper Catalysis. Angew. Chem. Int. Ed. 2015, 54, 1261–1265. 22) Shan Tang, Kun Liu, Chao Liu, and Aiwen Lei, Olefinic C-H functionalization through radical alkenylation. Chem. Soc. Rev. 2015, 44(5), 1070-1082. 23) Ke, J.; Tang, Y. L.; Yi, H.; Li, Y. L.; Cheng, Y. D.; Liu, C.; Lei, A. W., Copper-Catalyzed Radical/Radical C(sp3)-H/P-H Cross-Coupling: α-Phosphorylation of Aryl Ketone O-Acetyloximes. Angew. Chem. Int. Ed., 2015, 54, 6604-6607. 24) Zhang, G. T.; Liu, C.; Yi, H.; Meng, Q. Y.; Bian, C. L.; Chen, H.; Jian, J. X.; Wu, L. Z.; Lei, A. W., External Oxidant-Free Oxidative Cross-Coupling: A Photoredox Cobalt-Catalyzed Aromatic C-H Thiolation for Constructing C-S Bonds. J. Am. Chem. Soc. 2015, 137, 9273–9280.1 25) Tang, S.; Zeng, L.; Liu, Y. C.; Lei, A. W., Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: A Simple Access to Ynones. Angew. Chem. Int. Ed. 2015, 54, 15850 –15853. 26) Liu, C.; Yuan, J. W.; Gao, M.; Tang, S.; Li, W.; Shi, R. Y.; Lei, A. W., Oxidative Coupling between Two Hydrocarbons: An Update of Recent C-H Functionalizations. Chem. Rev., 2015, 115 (22), 12138–12204. 27) Wu, K.; Huang, Z. L.; Qi, X. T.; Li, Y. Z.; Zhang, G. H.; Liu, C.; Yi, H.; Meng, L. K.; Bunel, E. E.; Miller, J. T.; Pao, C. W.; Lee, J. F.; Lan, Y.; Lei, A. W., Copper-Catalyzed Aerobic Oxidative Coupling: From Ketone and Diamine to Pyrazine. Sci. Adv. 2015, Vol. 1, no. 9, e1500656. DOI: 10.1126/sciadv.1500656. 28) Zhou, L. L.; Yi, H.; Zhu, L.; Qi, X. T.; Jiang, H. P.; Liu, C.; Feng, Y. Q.; Lan, Y.; Lei, A. W., Tuning the Reactivity of Radical through a Triplet Diradical Cu(II) Intermediate in Radical Oxidative Cross-Coupling. Sci. Rep. 2015, 5, 15934, doi: 10.1038/srep15934. 29) Zhang, G.H.; Yi, H.; Zhang, G.T.; Deng, Y.; Bai, R.P.; Zhang, H.; Miller, J.T.; Kropf, A.J.; Bunel, E.E.; Lei, A. W., Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes. J Am Chem Soc 2014, 136, 924-926 30) Liu, J.; Liu, Q.; Yi, H.; Qin, C.; Bai, R. P.; Qi, X. T.; Lan, Y.; Lei, A. W., Visible Light Mediated Decarboxylation / Oxidative Amidation of α-Keto Acids with Amines under Mild Conditions Using O2. Angew Chem Int Ed 2014, 53, 502 31) Li, W.; Liu, C.; Zhang, H.; Ye, K.Y.; Zhang, G.H.; Zhang, W.Z.; Duan, Z.L.; You, S.L.; Lei, A. W., Palladium-Catalyzed Oxidative Carbonylation of N-allylamines for the synthesis of â-lactams. Angew Chem Int Ed 2014, 53, 2443 32) Wang, L.; Wang, Y.X.; Liu, C.; Lei, A. W., CO/C-H as the Acylative Reagent: A Palladium-Catalyzed Aerobic Oxidative Carbonylative Esterfication of Alcohols. Angew Chem Int Ed 2014, 53, 5657 33) Ruopeng Bai, Guanghui Zhang, Hong Yi, Zhiliang Huang, Xiaotian Qi, Chao Liu, Jeffrey T Miller, Arthur Jeremy Kropf, Emilio E Bunel, Yu Lan, and Aiwen Lei. Cu(II)/Cu(I)-Synergistic Cooperation to Lead the Alkyne C-H Activation. J. Am. Chem. Soc., 2014, 136, 16760–16763. 34) Liu, C.; Liu, D.; Lei, A. W., Recent Advance of Transition-Metal Catalyzed Radical Oxidative Cross-Couplings. Acc. Chem. Res. 2014, 47, 3459−3470. 35) He, C.; Zhang, G. H.; Ke, J.; Zhang, H.; Miller, J. T.; Kropf, A. J.; Lei, A. W., Labile Cu(I)-Catalyst/Spectator Cu(II)-Species in Copper-Catalyzed C-C Coupling Reaction: Operando IR, In situ XANES/EXAFS Evidence and Kinetic Investigations. J Am Chem Soc 2013, 135, 488 36) Lu, Q. Q.; Zhang, J.; Zhao, G. L.; Qi, Y.; Wang, H. M.; Lei, A. W., Dioxygen-Triggered Oxidative Radical Reaction: Direct Aerobic Difunctionalization of Terminal Alkynes towards β-Keto Sulfones. J Am Chem Soc 2013, 135, 11481 37) Muto, K.; Yamaguchi, J.; Lei, A. W.; Itami, K., Isolation, Structure, and Reactivity of an Arylnickel(II) Pivalate Complex in Catalytic C-H/C-O Biaryl Coupling. J Am Chem Soc 2013, 135, 16384 38) He, C.; Ke, J.; Xu, H.; Lei, A. W., Insights toward the Symbiotic Catalysis Sonogashira Coupling Reaction: Quantitative Kinetic Investigation of Transmetalation. Angew Chem Int Edit 2013, 52, 1527 39) Wang, J.; Liu, C.; Yuan, J. W.; Lei, A. W., Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α, β-unsaturated Ketones. Angew Chem Int Edit 2013, 52, 2256 40) Liu, D.; Liu, C.; Li, H.; Lei, A. W., Direct Funtionalization of Tetrahydrofuran and 1,4-Dioxane: A Nickel-Catalyzed Oxidative Csp3-H Arylation. Angew Chem Int Ed 2013, 52, 4453 41) Gao, M.; He, C.; Chen, H. Y.; Bai, R. P.; Cheng, B.; Lei, A. W., Synthesis of Pyrrole by Click Reaction: Silver-Catalyzed Cycloaddition of Terminal Alkynes with isocyanides. Angew Chem Int Edit 2013, 52, 6958 42) Huang, Z. L.; Jin, L. Q.; Feng, Y.; Peng, P.; Yi, H.; Lei, A. W., Iron-Catalyzed Oxidative Radical Cross-Coupling/Cyclization between Phenol and Olefin. Angew Chem Int Edit 2013, 52, 7151 43) Lu, Q. Q.; Zhang, J.; Wei, F. L.; Qi, Y.; Wang, H. M.; Liu, Z. L.; Lei, A. W., Dioxygen Activation by Sulfinic Acids: Direct Oxysulfonylation of Alkenes Leading to Secondary and Tertiary β-Hydroxysulfones. Angew Chem Int Ed 2013, 52, 7156 44) Meng, L. K.; Zhang, G. H.; Liu, C.; Wu, K.; Lei, A. W., Trifluoromethanesulfonic Acid Catalyzed Synergetic Oxidative/[3+2] Cyclization of Quinones with Olefins. Angew Chem Int Edit 2013, 52, 10195 45) Shi, R. Y.; Zhang, H.; Lu, L. J.; Chen, B. R.; Sha, Y. C.; Liu, C.; Lei, A. W., Palladium/Copper-Catalyzed Oxidative C-H Alkenylation/N-Dealkylative Carbonylation of Tertiary Anilines. Angew Chem Int Edit 2013, 52, 10582 46) Guo, M.; Dong, H.; Li, J.; Cheng, B.; Huang, Y. Q.; Feng, Y. Q.; Lei, A. W., Spectroscopic Observation of Iodosylarene Metalloporphyrin Adducts and Manganese(V)-Oxo Porphyrin Species in a Cytochrome P450 Analogue. Nature communications 2012, 3, 1190, DOI:10.1038/ncomms2196 47) He, C.; Guo, S.; Ke, J.; Hao, J.; Xu, H.; Chen, H. Y.; Lei, A. W., Silver-Mediated Oxidative C-H/C-H Functionalization: A Strategy To Construct Polysubstituted Furans. J Am Chem Soc 2012, 134, 5766 48) Zhang, H.; Shi, R. Y.; Ding, A. X.; Lu, L. J.; Chen, B. R.; Lei, A. W., Transition-metal-free Alkoxycarbonylation of Aryl Halides. Angew Chem Int Edit 2012, 51, 12542 49) Weng, Y.; Cheng, B.; He, C.; Lei, A. W., Rational Design of Pd-Catalyzed Csp-Csp Cross-Coupling Reaction Inspired by Kinetic Studies. Angew Chem Int Edit 2012, 51, 9547 50) Liu, C.; Tang, S.; Zheng, L.; Liu, D.; Zhang, H.; Lei, A. W., Covalently Bound Benzyl Ligand Promotes Selective Palladium-Catalyzed Oxidative Esterification of Aldehydes with Alcohols. Angew Chem Int Edit 2012, 51, 5662 51) Zhang, H.; Shi, R. Y.; Gan, P.; Liu, C.; Ding, A. X.; Wang, Q. Y.; Lei, A. W., Palladium-Catalyzed Oxidative Double C-H Functionalization/Carbonylation for the Synthesis of Xanthones. Angew Chem Int Edit 2012, 51, 5204 52) Liu, Q.; Wu, P.; Yang, Y. H.; Zeng, Z. Q.; Liu, J.; Yi, H.; Lei, A. W., Room-Temperature Copper-Catalyzed Oxidation of Electron-Deficient Arenes and Heteroarenes Using Air. Angew Chem Int Edit 2012, 51, 4666 53) Liu, C.; Tang, S.; Liu, D.; Yuan, J. W.; Zheng, L. W.; Meng, L. K; Lei, A. W., Nickel-Catalyzed Heck-Type Alkenylation of Secondary and Tertiary a-Carbonyl Alkyl Bromides. Angew Chem Int Edit 2012, 51, 3638 54) Liu, C.; Zhang, H.; Shi, W.; Lei, A. W., Bond Formations between Two Nucleophiles: Transition Metal Catalyzed Oxidative Cross-Coupling Reactions. Chem Rev 2011, 111, 1780. 55) Shi, W.; Liu, C.; Lei, A. W., Transition-metal catalyzed oxidative cross-coupling reactions to form C-C bonds involving organometallic reagents as nucleophiles. Chem Soc Rev 2011, 40, 2761. 56) Liu, Q.; Zhang, H.; Lei, A. W., Oxidative Carbonylation Reactions: Organometallic Compounds (R-M) or Hydrocarbons (R-H) as Nucleophiles. Angew Chem Int Edit 2011, 50, 10788. 57) Liu, C.; Wang, J.; Meng, L. K.; Deng, Y.; Li, Y.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Direct Esterification of Alcohols. Angew Chem Int Edit 2011, 50, 5144. 58) Liu, C.; Deng, Y.; Wang, J.; Yang, Y. Y.; Tang, S.; Lei, A. W., Palladium-Catalyzed C-C Bond Formation To Construct 1,4-Diketones under Mild Conditions. Angew Chem Int Edit 2011, 50, 7337. 59) Liu, W.; Cao, H.; Zhang, H.; Zhang, H.; Chung, K. H.; He, C. A.; Wang, H. B.; Kwong, F. Y.; Lei, A. W., Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C-H Arylation of Unactivated Benzene. J Am Chem Soc 2010, 132, 16737. 60) Hu, Y. H.; Liu, J.; Lu, Z. X.; Luo, X. C.; Zhang, H.; Lan, Y.; Lei, A. W., Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides. J Am Chem Soc 2010, 132, 3153. 61) Jin, L. Q.; Xin, J.; Huang, Z. L.; He, J.; Lei, A. W., Transmetalation is the Rate-Limiting Step: Quantitative Kinetic Investigation of Nickel-Catalyzed Oxidative Coupling of Arylzinc Reagents. J Am Chem Soc 2010, 132, 9607. 62) He, C. A.; Guo, S.; Huang, L.; Lei, A. W., Copper Catalyzed Arylation/C-C Bond Activation: An Approach toward alpha-Aryl Ketones. J Am Chem Soc 2010, 132, 8273. 63) Chen, M.; Zheng, X. L.; Li, W. Q.; He, J.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Cross-Coupling Reactions of Terminal Alkynes with Alkylzinc Reagents. J Am Chem Soc 2010, 132, 4101. 64) Liu, W.; Cao, H.; Lei, A. W., Iron-Catalyzed Direct Arylation of Unactivated Arenes with Aryl Halides. Angew Chem Int Edit 2010, 49, 2004. 65) Liu, Q.; Li, G.; He, J.; Liu, J.; Li, P.; Lei, A. W., Palladium-Catalyzed Aerobic Oxidative Carbonylation of Arylboronate Esters under Mild Conditions. Angew Chem Int Edit 2010, 49, 3371. 66) Duan, H.; Meng, L. K.; Bao, D. H.; Zhang, H.; Li, Y.; Lei, A. W., Zinc Chloride Enhanced Arylations of Secondary Benzyl Trifluoroacetates in the Presence of beta-Hydrogen Atoms. Angew Chem Int Edit 2010, 49, 6387. Publications before independent research 1) Collman, J. P.; Zeng, L.; Wang, H. J. H.; Lei, A. W.; Brauman, J. I. Eur. J. Org. Chem. 2006, 2707. 2) Shen, Z. M.; Lu, X. Y.; Lei, A. W. Tetrahedron 2006, 62, 9237. 3) He, M.; Lei, A. W.; Zhang, X. M. Tetrahedron Lett. 2005, 46, 1823. 4) Lei, A. W.; Lu, X. Y.; Liu, G. S. Tetrahedron Lett. 2004, 45, 1785. 5) Lei, A. W.; Wu, S. L.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2004, 126, 1626. 6) Lei, A. W.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2003, 125, 11472. 7) Lei, A. W.; He, M. S.; Wu, S. L.; Zhang, X. M. Angew. Chem. Int. Ed. 2002, 41, 3457. 8) Lei, A. W.; Waldkirch, J. P.; He, M. S.; Zhang, X. M. Angew. Chem., Int. Ed. 2002, 41, 4526. 9) Lei, A. W.; Liu, G. S.; Lu, X. Y. J. Org. Chem. 2002, 67, 974. 10) Lei, A. W.; Srivastava, M.; Zhang, X. M. J. Org. Chem. 2002, 67, 1969. 11) Lei, A. W.; He, M. S.; Zhang, X. M. J. Am. Chem. Soc. 2002, 124, 8198. 12) Lei, A. W.; Zhang, X. M. Org. Lett. 2002, 4, 2285. 13) Lei, A. W.; Zhang, X. M. Tetrahedron Lett. 2002, 43, 2525. 14) Lei, A. W.; Lu, X. Y. Org. Lett. 2000, 2, 2699. 15) Wang, Z.; Lu, X. Y.; Lei, A. W.; Zhang, Z. G. J. Org. Chem. 1998, 63, 3806.