田沺 - 武汉大学 - 化学与分子科学学院

研究领域

有机化学（化学生物学）从事有机小分子与生物大分子相互作用的研究，主要课题方向为小分子化合物作为Z-DNA 诱导剂或识别剂的设计合成及生物活性研究；小分子化合物与G-四链体相互作用的生物活性研究；用于活细胞内阳离子识别的化学传感器的设计合成及活性研究。

近期论文

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Libo Yuan, Tian Tian (并列第一作者), Yuqi Chen, Shengyong Yan,Xiwen Xing, Zhengan Zhang, Qianqian Zhai, Liang Xu, Shaoru Wang, Xiaocheng Weng, Bifeng Yuan, Yuqi Feng & Xiang Zhou* Existence of G-quadruplex structures in promoter region of oncogenes confirmed by G-quadruplex DNA cross-linking strategy. Scientific Reports 2013, doi:10.1038/srep01811. Tian Tian, Xiaoe Zhang, Boshi Fu, Yuelin Long, Shuang Peng, Shaoru Wang,* Xiang Zhou* and Xin Zhou, Systematic investigation of DNAs with modified cytosines under hot alkali treatment, Chemical Communications, 2013, 49, 9968—9970 Tian Tian, Shuang Peng, Heng Xiao, Yuelin Long, Boshi Fu, Xiaoe Zhang, Shan Guo, Shaoru Wang,* Xiang Zhou,* Songmei Liu and Xin Zhou, 5-Methyldeoxycytidine enhances the substrate activity of DNA polymerase, Chemical Communications, 2013, 49, 10085—10087 Tian Tian, Shuang Peng, Heng Xiao, Xiaoe Zhang, Shan Guo, Shaoru Wang, Xiang Zhou,* Songmei Liu and Xin Zhou Highly sensitive detection of telomerase based on a DNAzyme strategy. Chem. Commun. 2013, 49, 2652-2654. Tian Tian, Heng Xiao,Zhengan Zhang, Yuelin Long, Shuang Peng, Shaoru Wang,Xiang Zhou* Songmei Liu, Xin Zhou Sensitive and convenient detection of microRNAs based on cascade amplification by catalytic DNAzymes. Chemistry, a European Journal. 2013, 19, 92-95. Tian Tian, Heng Xiao, Xiaolian Zhang, Shuang Peng, Xiaoe Zhang, Shan Guo, Shaoru Wang, Songmei Liu, Xin Zhou, Craig Meyers and Xiang Zhou* Simultaneously sensitive detection of multiple miRNAs based on a strand displacement amplification.Chem. Commun. 2013, 49, 75-77. Tian Tian, Heng Xiao, Yuelin Long, Xiaoe Zhang, Shaoru Wang, Xiang Zhou*, Songmei Liu and Xin Zhou Sensitive analysis of DNA methyltransferase based on a hairpin-shaped DNAzyme Chem. Commun. 2012, 48, 10031-10033. Zhiguo Wu, Tian Tian (并列第一作者), Junping Yu, Xiaocheng Weng, Yi Liu, Xiang Zhou*, Formation of Sequence-Independent Z-DNA Induced by a Ruthenium Complex at Low Salt Concentrations. Angewandte Chemie-International Edition 2011, 50, 11962-11967. Zhiguo Wu, Mingliang Tang, Tian Tian*(并列通讯作者), Jianguo Wu, Yuanlin Deng, Xiaohu Dong, Zheng Tan, Xiaocheng Weng, Zhihong Liu, Chunjiang Wang, Xiang Zhou*, ―A specific probe for two-photon fluorescence lysosomal imaging, Talanta 2011, 87, 216– 221. Li Yang, Shaoru Wang, Tian Tian*( 并列通讯作者), Xiang Zhou*, Advancements in Z-DNA: development of inducers and stabilizers for B to Z transition, Curr Med Chem, 2012, 557-568. Tian Tian*,(并列通讯作者) Shaoru Wang, Jianguo Wu and Xiang Zhou*, ―Review: Advances in methodology of DNA methylation assay‖, Sci China Chem 2011, 54, 81233–1243 Tian Tian, Xiao Heng, Weng Xiaocheng, Wang Shaoru, Zhou Xiang*,Recent progress of nucleic acid probes based on small molecules Sci China Chem 2012, 42, 1700–1716