张扬会 - 同济大学 - 化学科学与工程学院

个人简介

教育情况 2007年10月 --- 2011年1月，博士后, The Scripps Research Institute, 圣地亚哥，加利弗尼亚州，美国。（导师：余金权教授） 2002年8月 --- 2007年8月，博士, 有机化学，佐治亚大学，雅典城，佐治亚州，美国。（导师：Geert-Jan Boons 教授） 1996年9月 --- 1999年2 月，硕士，有机化学，同济大学，上海。（导师：江致勤教授） 1991年9月 --- 1996年7 月，学士，应用化学，同济大学，上海工作经历 2011年1月 --- 现在，教授（博导），化学科学与工程学院，同济大学，上海 1999年5月 --- 2002年5月，助理研究员，中国科学院上海有机化学研究所，上海

研究领域

作为有机化学的核心学科，有机合成已成为生物、医药和材料等领域中的必不可少的工具，对环境和能源也影响极深。有机合成与人类的生活息息相关。本课题组主要进行有机合成的研究，在开始阶段侧重于研究有机方法学。有机分子的合成依靠于许多有机反应来实现，有机反应是有机合成的基础。尽管人们已发展了无数的有机反应，许多有机转变还非常困难，存在效率低下、过程复杂、成本太高和化学废物过多等问题, 不符合绿色化学的理念。在提倡可持续发展和绿色环保的二十一世纪，这些问题愈发显得重要和紧迫。因此，现代有机化学的当务之急是发展高效、原子经济型以及环境友好的有机反应。本课题组首先将要发展的有机反应是碳氢键的活化。有机合成主要依赖于有机官能团的相互转化，碳氢键活化无需借助于官能团的转变，可直接合成所需的有机分子，从而避免了化学废物的产生。此外，直接的碳氢键活化也给有机合成提供了一个全新的合成思路，并可大大提高合成效率。本组将要发展高效的，有实用价值的基于碳氢键活化的有机反应。长期目标是应用碳氢键活化直接合成有机分子，特别是药物分子。本课题组的另外一个研究领域是糖的合成。糖具有非常重要的生物活性，并有很好的药物开发前景。与多肽和多聚核苷酸相比，多糖化合物的结构复杂得多，合成也非常困难。本课题组将致力于发展高效的糖合成方法及多糖化合物的合成，并进行基于多糖化合物的生物研究和药物开发。

近期论文

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Shuai Yang; Yanghui Zhang*; Synthesis of 9-Fluorenylidenes via Pd-Catalyzed C-H Vinylation with Vinyl Bromides Org. Lett. 2021, 23, 7746. Zechen Wu; Cang Cheng; Yanghui Zhang*; Transition Metal-Catalyzed Reactions of C-H Bonds with Carbon Monoxide 有机化学, 2021, 41, 2155. Cang Cheng; Qiongqiong Zhu; Yanghui Zhang*; Intermolecular C-H Silylation through Cascade Carbopalladation and vinylic to aryl 1,4-palladium migration Chem. Commun. 2021, 57, 9700. Cang Cheng; Yanghui Zhang*; Palladium-Catalyzed anti-Carbosilylation of Alkynes to Access Isoquinolinone-Containing Exocyclic Vinylsilanes Org. Lett. 2021, 23, 5772. Zhuo Wu+; Zechen Wu+; Xueliang Sun; Weixin Qi; Zhengyang Zhang; Yanghui Zhang*; (+equal contribution) Palladium-Catalyzed Intramolecular Cross-Coupling of Unactivated C(sp3)-H and C(sp2)-H Bonds Org. Lett. 2021, 23, 7161. Zhuo Wu; Hang Jiang; Yanghui Zhang*; Pd-catalyzed cross-electrophile coupling/C-H alkylation reaction enabled by a mediator generated via C(sp3)-H activation Chem. Sci. 2021, 12, 8531. Bin Wan; Yanghui Zhang*; Synthesis of unsymmetrically substituted tetraphenylenes through palladium-catalyzed C(sp2)-H activation Synthesis. 2021, 53, 3299. Zhuo Wu; Feng Wei; Bin Wan; Yanghui Zhang*; Pd-catalyzed ipso,meta-dimethylation of ortho-substituted iodoarenes via a base-controlled C-H activation cascade with dimethyl carbonate as the methyl source J. Am. Chem. Soc. 2021, 143, 4524. Cang Cheng; Xiang Zuo; Dongdong Tu; Bin Wan; Yanghui Zhang*; Palladium-catalyzed diastereoselective cross-coupling of two aryl halides via C-H activation: synthesis of chiral eight-membered nitrogen heterocycles Chem. Commun. 2021, 57, 2939. Bin Wan; Zhuoer Lu; Zhuo Wu; Cang Cheng; Yanghui Zhang*; Diastereoselective construction of eight-membered carbocycles through palladium-catalyzed C(sp3)-H activation Org. Lett. 2021, 23, 1269. Cang Cheng; Dongdong Tu; Xiang Zuo; Zechen Wu; Bin Wan; Yanghui Zhang*; Palladium-catalyzed dual coupling reaction of 2-iodobiphenyls with ortho-bromoanilines through C-H activation: an approach for the synthesis of tribenzo[b,d,f]azepines Org. Lett. 2021, 23, 1239. Yichao Gu; Xueliang Sun; Bin Wan; Zhuoer Lu; Yanghui Zhang*; C(sp3)-H activation-enabled cross-coupling of two aryl halides: an approach to 9,10-dihydrophenanthrenes Chem. Commun. 2020, 56, 10942. Xiaoming Ji; Feng Wei; Bin Wan; Cang Cheng; Yanghui Zhang*; Palladium-catalyzed intermolecular C-H silylation initiated by aminopalladation Chem. Commun. 2020, 56, 7801. Cang cheng; Xiang Zuo; Dongdong Tu; Bin Wan; Yanghui Zhang*; Synthesis of 3,4-fused tricyclic indoles through cascade carbopalladation and C-H amination: development and total synthesis of rucaparib Org. Lett. 2020, 22, 4985. Xiaoming Ji; Yichao Gu; Cang Cheng; Zhuo Wu; Yanghui Zhang*; Palladium-catalyzed three-component reactions for synthesis of norborene-fused indanes Adv. Synth. Catal. 2020, 362, 1496. Xiaoming Ji; Guangfa Shi; Yanghui Zhang*; Progress of trifluoromethylation using trifluoroacetic acid and its derivatives as CF3-sources 有机化学, 2019, 39, 929. Cang Cheng; Bin Wan; Bo Zhou; Yichao Gu; Yanghui Zhang*; Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via heck carbonylation reactions: development and application to the synthesis of minalresat analogues Chem. Sci. 2019, 10, 9853 Xueliang Sun; Zhuo Wu; Weixin Qi; Xiaoming Ji; Cang Cheng; Yanghui Zhang*; Synthesis of indolines by palladium-catalyed intermolecular amination of unactivated C(sp3)-H bond Org. Lett. 2019, 21, 6508. Ding Ma; Xiaoming Ji; Zhuo Wu; Cang Cheng; Bo Zhou; Yanghui Zhang*; Synthesis of benzimidazoles through palladium-catalyed amination of 2-iodobenzimines with diaziridinone Adv. Synth. Catal. 2019, 361, 739. Bo Zhou; Ailan Lu; Yanghui Zhang*; Pd-catalyzed C-H silylation reactions with disilanes Synlett. 2019, 30, 685. Bo Zhou; Zhuo Wu; Weixin Qi; Xueliang Sun; Yanghui Zhang*; Synthesis of benzofulvenes through palladium-catalyzed sequential three-component reactions Adv. Synth. Catal. 2018, 360, 4480. Bo Zhou; Zhuo Wu; Ding Ma; Xiaoming Ji; Yanghui Zhang*; Synthesis of indoles through palladium-catalyzed three-component reaction of aryl iodides, alkynes, and diaziridione Org. Lett. 2018, 20, 6440. Bo Zhou; Ailan Lu; Changdong Shao; Xinda Liang; Yanghui Zhang*; Palladium-catalyzed sequential three-component reaction to access vinylsilanes Chem. Commun. 2018, 54, 10598. Xiaotian Ma; Ailan Lu; Xiaoming Ji; Guangfa Shi; Yanghui Zhang*; Disilylation of palladacycles that were generated through the C-H activation of aryl halides Asian J. Org. Chem. 2018, 7, 1403. Guangfa Shi; Changdong Shao; Xiaotian Ma; Yichao Gu; Yanghui Zhang*; Pd(II)-catalyzed Catellaini-type Domino reaction utilizing arylboronic acids as substrates ACS Catal. 2018, 8, 3775. Ailan Lu+; Xiaoming Ji+; Bo Zhou; Zhuo Wu; Yanghui Zhang*; (+equal contribution) Palladium-catalyzed C-H silylation through palladacycles generated from aryl halides Angew. Chem. Int. Ed. 2018, 57, 3233. Changdong Shao; Bo Zhou; Zhuo Wu; Xiaoming Ji; Yanghui Zhang*; Synthesis of carbazoles from 2-iodobiphenyls by palladium-catalyzed C-H activation and amination with diaziridinone Adv. Synth. Catal. 2018, 360, 887. Ding Ma; Guangfa Shi; Zhuo Wu; Xiaoming Ji; Yanghui Zhang*; Synthesis of 9,9-disubstituted fluorenes from 2-iodobiphenyls and α-diazoesters under palladium catalyst J. Org. Chem. 2018, 83, 1065. Changdong Shao; Zhuo Wu; Xiaoming Ji; Bo Zhou; Yanghui Zhang*; An approach to spirooxindoles via palladium-catalyzed remote C-H actvation and dual alkylation with CH2Br2 Chem. Commun. 2017, 53, 10429. Zhuo Wu; Ding Ma; Bo Zhou; Xiaoming Ji; Xiaotian Ma; Xiaoling Wang; Yanghui Zhang*; Palladium-catalyzed alkylation with alkyl halides by C( sp3)-H activation Angew. Chem. Int. Ed. 2017, 56, 12288. Xiaoling Wang; Xiaoming Ji; Changdong Shao; Yu Zhang; Yanghui Zhang*; Palladium-catalyzed C-H alkylation of 2-phenylpyridines with alkyl iodides Org. Biomol. Chem. 2017, 15, 5616.