Low, Philip S. - Purdue University - Department of Chemistry

个人简介

B.S., 1971, Brigham Young University; Ph.D., 1975, University of California, San Diego. Dr. Philip S. Low joined the faculty at Purdue University in 1976, where he is currently the Ralph C. Corley Distinguished Professor of Chemistry. Dr. Low has published over 270 refereed articles on various topics, including: 1) Structure and function of the human erythrocyte membrane, 2) Signal transduction across plant plasma membranes, 3) Design and development of receptor-targeted imaging and therapeutic agents for cancer and inflammatory diseases, and 4) Design and development of receptor-targeted imaging and therapeutic agents for cancer and inflammatory diseases. Dr. Low currently serves on four editorial boards and several external advisory boards for major institutions. Dr. Low has received both of Purdue University's awards for outstanding research, an NIH Merit Award, and several national and international research awards. He has organized multiple international/national conferences and chaired two Gordon Conferences. Dr. Low's research into receptor-targeted therapeutic and imaging agents has lead to more than 30 US patents/patents pending, and development of these patents has yielded 5 targeted drugs that are currently undergoing human clinical trials for kidney, ovarian, breast, lung, brain and endometrial cancers. Dr. Low has founded a company called Endocyte Inc. based on this latter technology.

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Folate receptor-β constitutes a marker for human proinflammatory monocytes. Shen J, Hilgenbrink AR, Xia W, Feng Y, Dimitrov DS, Lockwood MB, Amato RJ, Low PS. J Leukoc Biol 96:563-70 (2014). In vivo optical imaging of folate receptor-β in head and neck squamous cell carcinoma. Sun JY, Shen J, Thibodeaux J, Huang G, Wang Y, Gao J, Low PS, Dimitrov DS, Sumer BD. Laryngoscope 124:E312-9 (2014). Folate receptor-β in activated macrophages: Ligand binding and receptor recycling kinetics. Varghese B, Vlashi E, Xia W, Lopez W, Paulos C, Reddy J, Xu L, Low PS. Mol Pharm 11:3609-16 (2014). Evaluation of a cholecystokinin 2 receptor-targeted near infrared dye for fluorescence guided surgery of human cancers. Wayua C, Low P. Mol Pharm 11:468-76 (2014). Avidity Mechanism of Dendrimer-Folic Acid Conjugates. van Dongen M, Silpe J, Dougherty C, Kanduluru AK, Choi SK, Orr B, Low PS, Banaszak-Holl M. Mol Pharm 11:1696-706 (2014) 343. The effect of receptor occupancy on folate receptor internalization. Bandara NA, Hansen MJ, Low PS. Mol Pharm 11:1007-13 (2014). Assessment of folate receptor expression and folate uptake in multicentric lymphomas in dogs. Childress MO, Dhawan D, Leamon CP, Miller, MA, Ramos-Vara JA, Naughton JF, Low PS, Knapp DW. Am J Vet Rs 75:187-94. (2014). Chemical synthesis of staphyloferrin A and its application for Staphylococcus aureus detection. Pandy RK, Jarvis GG, Low PS. Org Biomol Chem 12:1707-10 (2014). Guiding principles in the design of ligand-targeted nanomedicines. Wang B, Galliford CV, Low PS. Nanomedicine (lond) 9:313-30 (2014). Use of folate-conjugated imaging agents to target alternatively activated macrophages in a murine model of asthma. Shen J, Chelvam V, Cresswell G, Low PS. Mol Pharm 10:1918-27 (2013). Spinal muscular atrophy: from gene discovery to clinical trials. Nurputra DK, Lai PS, Harahap NI, Morikawa S, Yamamoto T, Nishimura N, Kubo Y, Takeuchi A, Saito T, Takeshima Y, Tohyama Y, Tay SKh, Low PS, Saito K, Nishio H. Ann Hum Genet 77:435-63 (2013). Expression of functional folate receptors by human parathroid cells. Weber CJ, Müller S, Safley SA, gordon KB, Amancha P, Villinger F, Camp VM, Lipowska M, Sharma J, Müller C. Schibli R, Low PS, Leamon CP, Halkar RK. Surgery 154:1385-93 (2013). A phase I study of folate immune therapy (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) in patients with renal cell carcinoma. Amato R, Shetty AV, Lu J, Ellis R, Low PS. J Immunother 36:268-75 (2013). Effect of folate-targeted nanoparticle size on their rates of penetration into solid tumors. Vlashi E, Kelderhouse L, Sturgis J, Low PS. ACS Nano 7:8573-82. (2013). Label-free detection of Stapylococcus aureus captured on imutable ligand arrays. Adak AK, Boley JW, Lyvers DP, Chiu GT, Low PS, Reifenberger R, Wei A. ACS Appl Mater Interfaces Jul 5:6404-11. (2013). Development of tumor-targeted near infrared probes for fluorescence guided surgery. Kelderhouse L, Chelvam V, Wayua C, Mahalingam S, Poh S, Kularatne S, Low PS. Bioconjug Chem 24:1075-80. (2013). Comparative analysis of folate derived PET Imaging Agents with [(18)F]-2-fluoro-2-deoxy-d-glucose using a rodent inflammatory paw model. Kularatne SA, Bélanger MJ, Meng X, Connolly BM, Vanko A, Suresch DL, Guenther I, Wang S, Low PS, McQuade P, Trotter DG. Mol Pharm 5:3103-11. (2013). A bacterial phosphatase- like enzyme of the malaria parasite Plasmodium falciparum sesses tyrosine phosphatase activity and is implicated in the regulation of band 3 dynamics during parasite invasion. Fernandez-Pol S, Slouka Z, Bhattacharjee S, Fedotova Y, Freed S, An X, Holder AA, Campanella E, Low PS, Mohandas N, Haldar K. Eukaryot Cell12:1179-91. (2013). Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma. Grapp M, Wrede A, Schweuzer M, Huiwel S, Galla HJ, Snaidero N, Simons M, Buckers J, Low PS, Urlaub H, Gartner J, Steinfield R. Nat Commun. 4:2123. (2013). Small animal optical diffusion tomography with targeted fluorescence. Gaind, V.; Tsai H.R.; Webb, K.J.; Chelvam, V.; Low, P.S. J Opt Soc Am A Opt Image Sci Vis 30:1146-54. (2013). Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis. Gent, Y.Y.; Weijers, K.; Molthoff, C.F.; Windhorst, A.D.; Huisman, M.C.; Smith, D.E.; Kularatne, S.A.; Jansen, G.; Low, P.S.; Lammertsma, A.A.; van der Laken, C.J. Arthritis Res Ther. 15:R37. (2013).