孙彦 - 天津大学 - 化工学院

个人简介

Education Bachelor – 1983, Tianjin University, Tianjin, China (Chem. Eng.) Master (M. Eng) – 1987, University of Tokyo, Tokyo, Japan (Chem. Eng.) Doctorate (Dr. Eng.) – 1990, University of Tokyo, Tokyo, Japan (Chem. Eng.) Employment 1990 – 1991 Soken Chemical Eng. Co., Ltd., Tokyo, Japan 1991 – 1992 Lecturer, Dept. Chem. Eng., Tianjin University. 1992 – 1993 Associate Professor, Dept. Chem. Eng., Tianjin University. 1993 – present Professor, Dept. Biochem. Eng., Tianjin University. 2000 – present Cheung Kong Professor of the Ministry of Education of China, Tianjin University

研究领域

Bioseparations: – Protein adsorption and chromatography – Affinity ligand design and affinity purification – Protein refolding – Aqueous two-phase systems – Reverse micelles Biocatalysis: – Computation-based enzyme design – Development of multi-enzyme systems – Artificial biocatalytic photosynthesis – Enzyme modifications/immobilizations Inhibition of amyloid protein aggregation: – Inhibitor design and development – Amyloid formation mechanism

近期论文

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J Gao#, J-F Wang#, R-R Guo#, Y Hu, X-Y Dong, Q-H Shi, Y Sun*: Efficient cascade conversion of starch to gluconic acid by a chemoenzymatic system with co-immobilized Au nanoparticles and enzymes. Catalysis Science and Technology, 2023, 13: 991-999. Y Hu, Y Sun*: Self-propulsion of enzyme and enzyme-induced micro-/nanomotor. CIESC Journal, 2023, 74 (1): 116-132. Z-F Wang#, J Gao#, Q-H Shi#, X-Y Dong*, Y Sun: Facile purification and immobilization of organophosphorus hydrolase on protein-inorganic hybrid phosphate nanosheets. Chinese Journal of Chemical Engineering, 2023, 56： 119-125. X-Q Chen, W-Q Gao, Y Sun, X-Y Dong*: Multiple effects of polydopamine nanoparticles on Cu2+-mediated Alzheimer's β-amyloid aggregation. Chinese Journal of Chemical Engineering, 2023, 54： 144-152. X-D Lin, W Liu, X-Y Dong, Y Sun*: Epigallocatechin gallate-derived carbonized polymer dots: A multifunctional scavenger targeting Alzheimer's β-amyloid plaques. Acta Biomaterialia, 2023, 157： 524-537. Y Liu#, L Liu#, Z Qu, L-L Yu*, Yan Sun: Supramolecular assembly of benzophenone alanine and copper presents high laccase-like activity for degradation of phenolic pollutants. Journal of Hazardous Materials, 2023, 433： 130198. M-M Liu, W-J Wang, X-P Hao, X-Y Dong*: Seeding and Cross-seeding Aggregations of Aβ40 and hIAPP in Solution and on Surface. Acta Physico-Chimica Sinica, 2022, 38 (3): 2002024. L-K Su, K Chen, S Bai, L-L Yu*, Y Sun: Cutinase fused with C-terminal residues of a-synuclein improves polyethylene terephthalate degradation by enhancing the substrate binding. Biochemical Engineering Journal, 2022, 188： 108709. Y Hao, S Bai, L-L Yu*, Y Sun*: Magnetically driven muco-inert Janus nanovehicles for enhanced mucus penetration and cellular uptake. Molecules, 2022, 27： 7291. Y-R Qu, K Davey, Y Sun, A Middelberg, J-X Bi*: Engineered design of helix E structure on ferritin nanoparticles. ACS Applied Bio Materials, 2022, 5 (7): 3167-3179. F Ji, L Liu, L-L Yu*, Y Sun: Effects of Muco-inert and Acid-sensitive Modification on Mucosal Penetration of Nanoparticles. Chemical Journal of Chinese Universities, 2022, 43， 20210837. W Liu#, X-T Sun#, X-Y Dong, Y Sun*: Chiral LVFFARK enantioselectively inhibits amyloid-β protein fibrillogenesis. Chinese Journal of Chemical Engineering, 2022, 48: 227-235. S Bai, J Zhang, L-Y Zhu, X-X Gong, L-L Yu*, Y Sun: Characterization of a heptapeptide-modified microsphere for oriented antibody immobilization. Journal of Peptide Science, 2022, 28： e3411. Z-F Wang, Y Hu, S-P Zhang, Y Sun*: Artificial photosynthesis systems for solar energy conversion and storage: platforms and their realities. Chemical Society Review, 2022, 51： 6704-6737. W-J Wang, X-Y Dong, Y Sun*: A multi-target theranostic nano-composite against Alzheimer's disease fabricated by conjugating carbon dots and triple-functionalized human serum albumin. Acta Biomaterialia, 2022, 148: 298-309. S Liu, Z-F Wang, K Chen, Q-H Shi, X-Y Dong, Y Sun*: Cascade chiral amine synthesis catalyzed by site-specifically co-immobilized alcohol and amine dehydrogenases. Catalysis Science and Technology, 2022, 12： 4486-4497. K Chen, X-Y Dong, Y Sun*: Sequentially co-immobilized PET and MHET hydrolases via Spy chemistry in calcium phosphate nanocrystals present high-performance PET degradation. Journal of Hazardous Materials, 2022, 438, 129517. W Liu, Y Sun*: Research progress on β-amyloid protein aggregation and modulation. CIESC Journal, 2022, 73 (6)： 2381−2396. C-Y Zhang, Y Sun, X-Y Dong*: Conjugation of a zwitterionic polymer with dimethyl chains to lipase significantly increases the enzyme activity and stability. Chinese Journal of Chemical Engineering, 2022, 47, 48−53. X-Q Wang#, Z-F Wang#, L-L Yu, Q-H Shi, X-Y Dong, Y Sun*: Zwitterionic polymer-mediated immobilization of organophosphorus hydrolase enhances hydrolysis of methyl parathion by substrate enrichment. Biochemical Engineering Journal, 2022, 184: 108491. Y Liang#, W-J Wang#, Y Sun, X-Y Dong*: Insights into the cross-amyloid aggregation of Aβ40 and its N-terminal truncated peptide Aβ11-40 affected by epigallocatechin gallate. Chinese Journal of Chemical Engineering, 2022, 45: 284-293. W Liu#, H Zhang#, X-Y Dong, Y Sun*: Composite of gold nanoclusters and basified human serum albumin significantly boosts the inhibition of Alzheimer's β-amyloid by photo-oxygenation. Acta Biomaterialia, 2022, 144: 157-167. Y Hu#, Z-X Li#, Y Sun*: Ultrasmall enzyme/light-powered nanomotor facilitates cholesterol detection. Journal of Colloid and Interface Science, 2022, 621: 341-351. X-S Chu, X-H Yang, Q-H Shi*, X-Y Dong, Y Sun: Kinetic and molecular insight into immunoglobulin G binding to immobilized recombinant protein A of different orientations. Journal of Chromatography A, 2022, 1671: 463040. S-Y Xu, Y Sun, X-Y Dong*: Design of gallic acid-glutamine conjugate and chemical implications for its potency against Alzheimer's amyloid-β fibrillogenesis. Bioconjugate Chemistry, 2022, 33, 677−690. Z-X Li, K Chen, L-L Yu, Q-H Shi, Y Sun*: Fe3O4 nanoparticles-mediated solar-driven PET degradation with PET hydrolase. Biochemical Engineering Journal, 2022, 180: 108344. Z-F Wang, Y Sun*: A hybrid nanobiocatalyst with in situ encapsulated enzyme and exsolved Co nanoclusters for complete chemoenzymatic conversion of methyl parathion to 4-aminophenol. Journal of Hazardous Materials, 2022, 424: 127755. Y Hu, W Liu, Y Sun*: Self-propelled micro-/nanomotors as "on-the-move" platforms: Cleaners, sensors and reactors. Advanced Functional Materials, 2022, 32: 210918