王智文 - 天津大学

个人简介

讲授课程: 本科生专业核心课程：微生物学实验；选修课程：代谢工程与合成生物学硕士、博士研究生学位课：系统代谢工程与合成生物技术学术成就: 主持国家自然基金、国家重点研发计划课题与子课题，863计划子课题等国家级项目，省部级等项目和企业合作项目等，参编国家级规划教材《代谢工程》，高等教育出版社出版；发表SCI收录论文60余篇。 2014年入选北洋学者-青年骨干教师计划; 2019年科技部第六次国家技术预测专家； 2021年入选天津大学英才副教授。科研项目: 主持： 11)、国家重点研发计划子课题-电能细胞设计与构建-复合代谢网络模型的构建与电能驱动还原力合成 2019.07-2024.06 10)、天津市自然科学基金项目-谷氨酸棒杆菌解除葡萄糖抑制效应的调控机制 2019.04-2022.03 9)、生态环保部生物多样性调查与评估项目-现代生物技术对生物多样性影响的研究 2019.06-2020.06 8）、国家自然科学基金面上项目—大肠杆菌基因组尺度调控因子工程与适应性研究 2018-2021 7）、国家自然科学基金面上项目—枯草芽孢杆菌合成核黄素的基因组工程研究 2016.01-2019.12； 6）、国家自然科学基金青年基金项目—基于高产核黄素枯草芽孢杆菌全基因组突变分析的逆向代谢工程研究 2013.01-2015.12； 5）、“863”计划项目课题—生化网络重构与维生素生产新菌种 2012.11-2015.12； 4）、天津市青年基金项目—谷氨酸棒杆菌高效共利用葡萄糖和木糖的研究 2015.04-2018.03； 3）、自主创新基金—枯草芽孢杆菌基于CRISPR基因组编辑技术的构建 2017.01-2018.12； 2）、自主创新基金—基于RNA-Seq的核黄素高产菌株突变分析与调控机理研究 2015.01-2016.12； 1）、自主创新基金—高产核黄素枯草芽孢杆菌的逆向代谢工程研究 2013.01-2014.12；参与： 5）、国家自然基金面上项目—枯草芽孢杆菌微氧代谢木糖机理和产乙偶姻的代谢工程研究 2016.01-2019.12； 4）、国家自然基金重大项目—新一代代谢网络模型构建与产品合成最优途径设计 2014.01-2018.12； 3）、“973”计划课题—生物基材料合成途径的DNA模块设计与组装 2012.01-2016.08； 2）、国家自然基金面上项目—枯草芽孢杆菌基因组最小化的研究 2011.01-2015.12 1）、“973”计划课题—化学品代谢途径的模拟设计和组合优化 2011.01-2016.08 。专著：赵学明，陈涛，王智文等. 代谢工程，高等教育出版社，2015.03.

研究领域

基于基因组尺度网络模型构建与模拟设计，结合基因组编辑系统构建与合成生物学调控元件开发，通过先进的代谢工程与合成生物技术，改进微生物利用廉价生物质资源合成生物基化学品、生物医药和生物能源的性能，构建人工合成细胞工厂；系统生物学方法分析和探讨工业菌株遗传调控机制，结合工艺优化，降低产品成本，提高菌株的经济性。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Biosynthesis of Nicotinamide Mononucleotide: Current Metabolic Engineering Strategies, Challenges, and Prospects Fermentation 2023-06 | Journal article | Author DOI: 10.3390/fermentation9070594 CONTRIBUTORS: Shiqi Luo; Juntao Zhao; Yangyang Zheng; Tao Chen; Zhiwen Wang Microbial Synthesis of Heme b: Biosynthetic Pathways, Current Strategies, Detection, and Future Prospects Molecules 2023-04 | Journal article | Author DOI: 10.3390/molecules28083633 CONTRIBUTORS: Qiuyu Yang; Juntao Zhao; Yangyang Zheng; Tao Chen; Zhiwen Wang Advances in biological production of acetoin: a comprehensive overview Critical Reviews in Biotechnology 2022 | Journal article DOI: 10.1080/07388551.2021.1995319 WOSUID: WOS:000720762500001 CONTRIBUTORS: Cui, Zhenzhen; Wang, Zhiwen; Zheng, Meiyu; Chen, Tao Enhanced 3-Hydroxypropionic Acid Production From Acetate via the Malonyl-CoA Pathway in Corynebacterium glutamicum Frontiers in Bioengineering and Biotechnology 2022 | Journal article DOI: 10.3389/FBIOE.2021.808258 WOSUID: WOS:000747948600001 CONTRIBUTORS: Chang, Zhishuai; Dai, Wei; Mao, Yufeng; Cui, Zhenzhen; Zhang, Zhidan; Wang, Zhiwen; Ma, Hongwu; Chen, Tao Metabolic engineering of Corynebacterium glutamicum for efficient production of optically pure (2R,3R)-2,3-butanediol Microbial Cell Factories 2022 | Journal article DOI: 10.1186/S12934-022-01875-5 WOSUID: WOS:000829949800002 CONTRIBUTORS: Kou, Mengyun; Cui, Zhenzhen; Fu, Jing; Dai, Wei; Wang, Zhiwen; Chen, Tao Adaptive Laboratory Evolution of Halomonas bluephagenesis Enhances Acetate Tolerance and Utilization to Produce Poly(3-hydroxybutyrate) Molecules 2022-05 | Journal article | Author DOI: 10.3390/molecules27093022 CONTRIBUTORS: Jing Zhang; Biao Jin; Jing Fu; Zhiwen Wang; Tao Chen A comparative analysis of China and other countries in metabolic engineering: Output, impact and collaboration Chinese Journal of Chemical Engineering 2021 | Journal article DOI: 10.1016/J.CJCHE.2020.12.007 WOSUID: WOS:000651052100005 CONTRIBUTORS: Chen, Cong; Chen, Tao; Wang, Zhiwen; Zhao, Xueming Advances in biotechnological production of beta-alanine World Journal of Microbiology and Biotechnology 2021 | Journal article DOI: 10.1007/S11274-021-03042-1 WOSUID: WOS:000637498900001 CONTRIBUTORS: Wang, Leilei; Mao, Yufeng; Wang, Zhiwen; Ma, Hongwu; Chen, Tao Cell Catalysis of Citrate to Itaconate by Engineered Halomonas bluephagenesis ACS Synthetic Biology 2021 | Journal article DOI: 10.1021/ACSSYNBIO.1C00320 WOSUID: WOS:000744262500009 CONTRIBUTORS: Zhang, Jing; Jin, Biao; Hong, Kunqiang; Lv, You; Wang, Zhiwen; Chen, Tao Improving diacetyl production in Corynebacterium glutamicum via modifying respiratory chain Journal of Biotechnology 2021 | Journal article DOI: 10.1016/J.JBIOTEC.2021.03.014 WOSUID: WOS:000648868900003 CONTRIBUTORS: Chen, Cong; Cui, Zhenzhen; Zhao, Juntao; Li, Shuting; Ren, Xiaoting; Chen, Tao; Wang, Zhiwen Improving riboflavin production by knocking down ribF, purA and guaC genes using synthetic regulatory small RNA Journal of Biotechnology 2021 | Journal article DOI: 10.1016/J.JBIOTEC.2021.05.007 WOSUID: WOS:000667480200003 CONTRIBUTORS: Hu, Wenya; Liu, Shuang; Wang, Zhiwen; Chen, Tao Microbial extracellular electron transfer and strategies for engineering electroactive microorganisms Biotechnology Advances 2021 | Journal article DOI: 10.1016/J.BIOTECHADV.2020.107682 WOSUID: WOS:000723614200002 CONTRIBUTORS: Zhao, Juntao; Li, Feng; Cao, Yingxiu; Zhang, Xinbo; Chen, Tao; Song, Hao; Wang, Zhiwen Rational Engineering of Escherichia coli for High-Level Production of Riboflavin Journal of Agricultural and Food Chemistry 2021 | Journal article DOI: 10.1021/ACS.JAFC.1C04471 WOSUID: WOS:000710964600017 CONTRIBUTORS: Liu, Shuang; Hu, Wenya; Wang, Zhiwen; Chen, Tao Zhenzhen Cui,‡ Yufeng Mao,‡ Yujiao Zhao, Meiyu Zheng, Zhiwen Wang,* Hongwu M *, Tao Chen*. One-pot efficient biosynthesis of (3R)-acetoin from pyruvate by a two-enzyme cascade, Catalysis Science & Technology, 2020, 10: 7734-7744 Cong Chen, Alaksh Choudhury, Shuanghong Zhang, Andrew D. Garst, Xin Song, Xunli Liu, Tao Chen, Ryan T. Gill, Zhiwen Wang*. Integrating CRISPR-Enabled Trackable Genome Engineering and Transcriptomic Analysis of Global Regulators for Antibiotic Resistance Selection and Identification in Escherichia coli, mSystems, 2020, 5(2): e00232-20. Kun-Qiang Hong, Xiao-Meng Fu, Hao Yin, Shu-Ting Li, Tao Chen, Zhi-Wen Wang*. Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin, Critical Reviews in Analytical Chemistry, 2020, 1-12. Dingyu Liu, Can Huang, Jiaxin Guo, Peiji Zhang, Tao Chen, Zhiwen Wang*, Xueming Zhao. Development and characterization of a CRISPR/Cas9n-based multiplex genome editing system for Bacillus subtilis, Biotechnology for Biofuels, 2019, 12:197.

学术兼职

本领域多个期刊如Metabolic Engineering, Biotechnology and Bioengineering, Biotechnology for Biofuels, ACS Synthetic Biology, Microbiology Cell Factories，Molecular BioSystems, Bioresource Technology, Applied Microbiology and Biotechnology, PloS One, World Journal of Microbiology and Biotechnology, Bioresources and Bioprocessing, Biotechnology Letter, 生物工程学报等期刊审稿人；美国化学工程师协会（AIChE）会员；国际代谢工程学会(IMES)会员；中国化学会会员；国家自然基金委同行评审专家。